Antihypertensives prevent CVD even when BP normal

Latest

Antihypertensives prevent CVD even when BP normal

In Latest

Antihypertensives can prevent serious cardiovascular disease (CVD) even among adults with normal blood pressure, new research suggests

Antihypertensives’ benefits emerged, regardless of baseline blood pressure, in people who previously had a myocardial infarction or stroke, and in those who never developed CVD. 

Researchers pooled data from 344,716 adults (average age 65 years) in 48 randomised trials. Of these, 186,988 had not been diagnosed with CVD. Of those with and without a history of CVD, 19.8 and 8.0 per cent respectively had normal or high-normal systolic blood pressure (less than 130mmHg) at baseline. Clinical guidelines typically limit antihypertensives to people with blood pressure above 140/90mmHg.

During a median follow-up of 4.15 years, 12.3 per cent of participants experienced at least one major cardiovascular event, including ischaemic heart disease (5.6 per cent), stroke (4.0 per cent), CV death (3.4 per cent) and heart failure (2.4 per cent). Overall mortality was 8.4 per cent. Each 5mmHg fall in systolic blood pressure reduced the risk of stroke and heart failure by about 13 per cent, major CVD by about 10 per cent, ischaemic heart disease by 8 per cent and cardiovascular death by 5 per cent.

The study suggests that “a fixed degree of pharmacological blood pressure lowering is similarly effective for primary and secondary prevention of major cardiovascular disease, even at blood pressure levels currently not considered for treatment”.

The study did not, however, assess other outcomes that antihypertensives may partially prevent, such as valvular heart disease, peripheral vascular disease, atrial fibrillation or diabetes, or potential harms.

“This new evidence tells us that decisions to prescribe blood pressure medication should not be based simply on a prior diagnosis of cardiovascular disease or an individual’s blood pressure level,” says lead author Professor Kazem Rahimi from the University of Oxford.

“Instead, medication should be viewed as an effective tool for preventing cardiovascular disease in people at increased risk of developing heart disease or stroke. Clinical guidelines should be changed to reflect these findings.”

Record my learning outcomes

Latest

Inspiring stories related to health, fitness and the pursuit of wellbeing

Share:

More like this

bookmark_icon_off
Latest

Pharmacy flu jabs up almost 40% in Wales year on year

The number of flu jabs administered in a community pharmacy in Wales has risen by 37 per cent in the current flu season compared to last year.

1 Min Article

bookmark_icon_off
Latest

Fluoxetine 40mg capsule SSP issued with immediate effect

The Department of Health and Social Care has issued a Serious Shortage Protocol for fluoxetine 40mg capsules in light of ongoing supply chain disruption.

1 Min Article

bookmark_icon_off
Latest

Timoney becomes first pharmacist to chair SIGN council

The director of pharmacy for NHS Lothian Angela Timoney clocks up another first as chair of SIGN council.

1 Min Article

bookmark_icon_off
Latest

NPA chair steps aside amid CMA allegations

Nitin Sodha is stepping aside immediately while the CMA investigates allegations of collusion against Lexon UK, a company of which he is a director

1 Min Article

bookmark_icon_off
Latest

Scrap the prescription charge during pandemic, Government urged

Pharmacy bodies are urging the Government to scrap all prescription charges in England for the duration of the Covid-19 pandemic.

1 Min Article

bookmark_icon_off
Latest

Hannbeck leaves NPA to become new AIM boss

NPA chief pharmacist Leyla Hannbeck has left the NPA after 10 years to become the new chief executive of AIM.

1 Min Article

Recommended Learning

bookmark_icon_off
OTC

Treating constipation in the pharmacy

Understand how different laxatives work so you can make the best recommendations for your customers

3 Min Module

bookmark_icon_off
Sponsored education

Next-level parasite protection for dogs

Explore the FRONTLINE Tri-Act® active pack to learn about next-level parasite protection for dogs.

10 Min Module

bookmark_icon_off
Sponsored education

Supporting customers to sleep better

Explore the rotating pack shot to find out more about Nytol Liquid Caramel Flavour, a clinically-proven alternative to sleeping tablets, and understand how you can support customers to sleep better.

5 Min Module

bookmark_icon_off
Sponsored education

Frontline Tackling Fleas & Ticks

This NPA-accredited module will enable you to have confident conversations with customers, helping them manage fleas and ticks both on their pets and in the home.

10 Min Module

Sponsored education

Supporting parents of babies with feeding issues

Common feeding feeding issues, including coloc, reflux and regurgitation, and some of the ways they can be managed

10 Min Module

bookmark_icon_off
Sponsored education

Update your knowledge of erection problems with key learning updates from recent research

2 Min Module