CMPA symptoms

There are two types of CMPA that differ depending on how the immune system reacts. The symptoms can be caused by immunogloblin E (IgE), or due to a different part of the immune system reacting in another way; non immunogloblin E (non-IgE).

Immunoglobulin E (IgE) mediated responses occur quickly, usually within 20-30 minutes, and up to 2 hours after ingestion. Non-IgE mediated symptoms are typically delayed, between 2 and 72 hours from ingestion.¹⁹

Being aware of the different symptoms and how they can appear at different times may help you to understand what might be linked to CMPA when discussing any concerns with parents.

Click on the hotspots to find out more about symptoms of CMPA^19*

Symptoms and signs of anaphylaxis or other systemic allergic reactions

IgE mediated skin reactions

• Pruritis (itching)
• Erythema
• Acute urticaria (hives)
• Acute swelling - mostly affecting lips, face or area around the eye
• Atopic eczema (flare-up of pre-existing eczema)

Non-IgE mediated skin reactions

• Pruritis
• Erythema or flushing
• Atopic eczema

IgE mediated digestive system reactions

• Angioedema of the lips, tongue and palate
• Oral pruritis
• Nausea
• Colicky abdominal pain or discomfort
• Vomiting
• Diarrhoea

Non-IgE mediated digestive system reactions

• Gastro-oesophageal reflux disease (GORD)
• Vomiting
• Loose and/or frequent stools
• Blood and/or mucus in stools
• Abdominal pain/discomfort
• Colic and/or irritability
• Refusing or avoiding food
• Straining to pass soft stools
• Perianal redness
• Pallor and tiredness
• Faltering growth, with at least one or more gastrointestinal symptoms may indicate severe allergy

IgE mediated respiratory reactions

• Itchy and/or runny nose
• Congestion
• Sneezing
• Chest tightness
• Wheezing
• Shortness of breath
• Cough

Non-IgE mediated respiratory reactions

• Cough
• Chest tightness
• Wheezing
• Shortness of breath

^*NOTE: This list is not exhaustive and absence of these does not exclude a potential food allergy.