Fluconazole should be avoided during pregnancy

Clinical

Fluconazole should be avoided during pregnancy

In Clinical

Maternal exposure to even a single dose of oral fluconazole during pregnancy may increase the risk of spontaneous abortion, according to new Canadian research. Moreover, doses higher than 150mg during the first trimester may increase the risk of cardiac septal closure anomalies.

The authors identified women exposed to low- (150mg or less) and high-dose (more than 150mg) oral fluconazole and matched each case of spontaneous abortion or stillbirth with up to five controls.

The researchers analysed 320,868 spontaneous abortions, 226,599 major congenital malformations and 7,832 stillbirths. About two-thirds (69.5 per cent) of women exposed to fluconazole in pregnancy received a single dose of 150mg.

Using oral fluconazole during early pregnancy was associated with a two- to three-fold increase in the risk of spontaneous abortion compared with no exposure (adjusted odds ratios 2.23 for low dose, 3.20 for high dose).

Taking fluconazole during the first trimester did not increase the risk of major congenital malformations but exposure to high-dose fluconazole during the first trimester was associated with an 81 per cent increase in the risk of cardiac septal closure anomalies. No association emerged between fluconazole and stillbirth.

The study has limitations, such as a lack of information on possible confounders including smoking, use of OTC folic acid and alcohol intake, leading the authors to comment that the “findings are consistent with other studies in the literature, but require replication”.

Record my learning outcomes

Clinical

Inspiring stories related to health, fitness and the pursuit of wellbeing

Share:

More like this

bookmark_icon_off
Clinical

Metabolic syndrome and the link to skin diseases

Patients with inflammatory skin diseases should be targeted and provided with heart health checks by community pharmacy teams.

4 Min Article

bookmark_icon_off
Clinical

When conceiving is a problem

Having some insight into assisted conception can transform any interaction when counselling women.

3 Min Article

bookmark_icon_off
Clinical

Pharmacists' role in diabetes care highlighted

A new report highlights community pharmacy's role in preventing and treating diabetes.

1 Min Article

bookmark_icon_off
Clinical

Covid-19: Playing the long game

Observational studies and clinical trials need to determine how long the changes in people with Covid persist and come up with ways to treat and prevent long-Covid, writes Mark Greener

3 Min Article

bookmark_icon_off
Clinical

Time for action on obesity

The UK population is more obese and less active than ever before. Can pharmacists help turn things around?

5 Min Article

bookmark_icon_off
Clinical

Briefing: a novel approach to treating depression

Could a headset that delivers transcranial direct-current stimulation be the next big thing in treating depression?

2 Min Article

Recommended Learning

bookmark_icon_off
Sponsored education

Abdominal discomfort: Multi-symptom relief with Buscomint

Discover the key benefits of a product that offers multi-symptom relief from abdominal pain, cramps and bloating, plus lifestyle advice to help manage symptoms.

5 Min Module

Sponsored education

Dry eye consultations

Work through a customer consultation to determine the possible cause of stinging, gritty eyes and recommend an effective treatment to help ease these symptoms.

15 Min Module

bookmark_icon_off
Bayer Business Programme

Let's talk tech: Using technology to drive your business

This training offers insights into making the most of technology and the commercial opportunities this can offer your business.

 

8 Min Module

bookmark_icon_off
Sponsored education

Helping customers treat & care for their scalp

Understanding the causes and symptoms of some common scalp conditions will help you to make a real difference to your customers’ lives. Complete this module to discover self-care and product advice to help ease symptoms and maintain scalp health.

10 Min Module

bookmark_icon_off
Sponsored education

Pain conversations - making effective recommendations

Explore our detailed case studies to help understand how to advise customers on different causes of pain.

15 Min Module

bookmark_icon_off
Sponsored education

This module will help the pharmacy team to understand erectile dysfunction and its causes, and supply Viagra Connect to male customers affected by it, where appropriate

10 Min Module