Cardiovascular
Palpitations
Last revised in February 2026
Palpitations are an abnormally perceived heartbeat including a feeling of the heart racing, an irregularity, or pounding sensation
Palpitations: Summary
- The term palpitations is used to describe an abnormally perceived heartbeat and/or an uncomfortable or unpleasant awareness of the heartbeat or rhythm.
- This can include a feeling of the heart racing, fluttering in the chest, skipped beats, irregularity, or an unusual pounding or thumping sensation in the chest or neck.
- Palpitations are a non-specific symptom that has a variety of causes which may co-exist, ranging from the benign to potentially life-threatening, including:
- Cardiac arrhythmias — such as supraventricular/ventricular extrasystoles or tachycardias; atrial fibrillation or flutter.
- Structural heart disease — such as heart valve disease, heart failure, and hypertrophic cardiomyopathy.
- Psychological — such as anxiety, stress, and/or panic attacks.
- Systemic — such as hyperthyroidism; menopause; pregnancy; fever; anaemia; hypovolaemia.
- Drugs — such as medications that prolong the QT interval; alcohol; caffeine; nicotine; cocaine; heroin; amphetamines; ecstasy; and cannabis.
- Assessment of a person with palpitations should include:
- Asking about onset, duration, frequency, triggers, nature, and rhythm; associated symptoms including breathlessness, chest pain, syncope or near syncope; personal or family history of heart disease, arrhythmia or sudden cardiac death under the age of 40 years; comorbidities; any drugs; lifestyle, psychosocial factors, and impact on quality of life.
- Examination to assess vital signs, including heart rate and rhythm, blood pressure, body mass index (BMI), any heart murmur, signs of heart failure or systemic comorbidities.
- Arranging a 12-lead electrocardiogram (ECG) ideally during an episode of palpitations to assess for arrhythmias or features of increased risk of arrhythmia.
- Emergency hospital admission should be arranged if a person has current palpitations and:
- Ventricular tachycardia or persistent supraventricular tachycardia on ECG.
- Is haemodynamically unstable.
- High-risk structural heart disease.
- A suspected serious underlying cause or complication.
- Urgent cardiology referral should be arranged if a person has:
- A history of palpitations with associated symptoms.
- Palpitations triggered by exercise.
- A family history of sudden cardiac death under the age of 40 years or hypertrophic cardiomyopathy.
- Routine cardiology referral should be arranged if a person has:
- A history of palpitations of uncertain cause needing ambulatory ECG monitoring.
- A history or symptoms of structural heart disease, heart failure, or hypertension.
- A resting ECG abnormality.
- A history of recurrent sustained tachyarrhythmia, atrial fibrillation or flutter, or paroxysmal supraventricular tachycardia.
- Frequent ventricular extrasystoles.
- Primary care management of a person with palpitations includes:
- Arranging blood tests to help identify any underlying cause, and managing appropriately.
- Arranging an echocardiogram if a heart murmur, heart failure, or structural heart disease is suspected.
- Performing a cardiovascular risk assessment and managing appropriately.
- Advising on lifestyle measures such as reducing or avoiding stress, caffeine, alcohol, smoking, and causative drugs.
- Offering reassurance if there are no concerning features on ECG and no clinical evidence of underlying cardiac or other systemic disease.
- Considering cardiology referral if palpitations remain poorly controlled, symptomatic, and/or distressing.
- Advising about safe driving, work, and leisure activities.
- Advising about sources of information and support.
Have I got the right topic?
From age 16 years onwards.
This CKS topic covers the management of young people and adults presenting with palpitations caused by extrasystoles and various types of tachycardia.
This CKS topic does not cover the management of people presenting with bradycardia.
There are separate CKS topics on Blackouts and syncope, Atrial fibrillation, and CVD risk assessment and management.
The target audience for this CKS topic is healthcare professionals working within the NHS in the UK, and providing first contact or primary healthcare.
How up-to-date is this topic?
Changes
February 2026 — reviewed. A literature search was conducted in January 2026 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. Brief information about the use of patient-activated electrocardiogram (ECG) devices has been added. No major changes to the recommendations have been made.
Previous changes
March to April 2020 — reviewed. A literature search was conducted in March 2020 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of this topic. The topic has undergone restructuring. No major changes to the recommendations have been made.
March to May 2015 — reviewed. A literature search was conducted in March 2015 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last version of this topic. Initiation of empirical beta-blockers in primary care is no longer recommended.
November 2008 to March 2009 — converted from CKS guidance to CKS topic structure. The evidence-base was reviewed in detail, and recommendations are more clearly justified and transparently linked to the supporting evidence. There were no major changes to the recommendations.
September 2008 — minor correction to the Changes section. Issued September 2008.
October 2005 — minor technical update. Issued in November 2005.
March 2005 — rewritten. Validated in June 2005 and issued in July 2005.
January 2002 — reviewed. Validated in March 2002 and issued in April 2002.
December 1998 — rewritten replacing guidance on Paroxysmal supraventricular tachycardia. Validated in March 1999 and issued in May 1999.
Update
New evidence
Evidence-based guidelines
No new evidence-based guidelines since 1 January 2026.
HTAs (Health Technology Assessments)
No new HTAs since 1 January 2026.
Economic appraisals
No new economic appraisals relevant to England since 1 January 2026.
Systematic reviews and meta-analyses
No new systematic reviews or meta-analysis which reach the CKS threshold for inclusion since 1 January 2026.
Primary evidence
No new primary evidence which reaches the CKS threshold for inclusion published since 1 January 2026.
New policies
No new national policies or guidelines since 1 January 2026.
New safety alerts
No new safety alerts since 1 January 2026.
Changes in product availability
No changes in product availability since 1 January 2026.
Goals and outcome measures
Goals
To support primary healthcare professionals to:
- Assess and manage a person currently experiencing or with a history of palpitations, and arrange hospital admission or cardiology referral if clinically indicated.
- Arrange investigations in primary care if clinically indicated.
- Assess and manage any cardiovascular risk factors, and give appropriate lifestyle advice.
Outcome measures
No outcome measures were found during the review of this topic.
Audit criteria
No audit criteria were found during the review of this topic.QOF indicators
No QOF indicators were found during the review of this topic.QIPP - Options for local implementation
No QIPP indicators were found during the review of this topic.NICE quality standards
No NICE quality standards were found during the review of this topic.Background information
What is it?
- Palpitations are among the most common symptoms that patients present with to general practice, cardiology, and emergency healthcare services [Raviele, 2011].
- The term palpitations is used to describe an abnormally perceived heartbeat and/or an uncomfortable or unpleasant awareness of the heartbeat or rhythm [Wolff, 2009; Raviele, 2011; Gale, 2016; Chua, 2024; Ribero-Vargas, 2025].
- This can include a feeling of the heart racing, fluttering in the chest, skipped beats, an irregularity, or an unusual pounding or thumping sensation in the chest or neck [Weinstock, 2021; Chua, 2024; Ribero-Vargas, 2025].
- Some people describe feeling like they have to cough or that their breath is being taken away [Wolff, 2009; Gale, 2016].
What causes it?
- Palpitations are a non-specific symptom that has a variety of possible causes which may co-exist, ranging from the benign to potentially life-threatening [Raviele, 2011; Weinstock, 2021].
- Cardiac arrhythmias
- Supraventricular/ventricular extrasystoles or tachycardias — the latter can be life-threatening [Weinstock, 2021].
- Atrial fibrillation or flutter [Weinstock, 2021]. See the CKS topic on Atrial fibrillation for more information.
- Anomalies in the functioning of pacemakers and implantable cardioverter defibrillators (ICDs), [Weinstock, 2021]. See the CKS topic on Heart failure - chronic for more information.
- Structural heart disease
- Mitral valve prolapse [Weinstock, 2021].
- Severe mitral or aortic regurgitation [Weinstock, 2021].
- Aortic stenosis [Weinstock, 2021].
- Mechanical prosthetic valves [Giada, 2018].
- Congenital heart disease with significant shunt [Giada, 2018; Weinstock, 2021].
- Cardiomegaly or hypertrophic cardiomyopathy — the latter can be life-threatening [Weinstock, 2021].
- Heart failure [Weinstock, 2021]. See the CKS topic on Heart failure - chronic for more information.
- Psychological
- Anxiety, stress, and panic attacks. See the CKS topics on Generalized anxiety disorder and Post-traumatic stress disorder for more information [Wolff, 2009; Weinstock, 2021; Ribero-Vargas, 2025].
- Depression [Wolff, 2009; Ribero-Vargas, 2025]. See the CKS topics on Depression and Depression - antenatal and postnatal for more information.
- Systemic
- Hyperthyroidism [Weinstock, 2021; Ribero-Vargas, 2025]. See the CKS topic on Hyperthyroidism for more information.
- Hypoglycaemia [Weinstock, 2021; Ribero-Vargas, 2025].
- Menopause [Weinstock, 2021; Ribero-Vargas, 2025]. See the CKS topic on Menopause for more information.
- Pregnancy [Weinstock, 2021; Ribero-Vargas, 2025]. See the CKS topic on Antenatal care - uncomplicated pregnancy for more information.
- Fever [Weinstock, 2021; Ribero-Vargas, 2025]. See the CKS topics on Neutropenic sepsis and Sepsis for more information.
- Anaemia [Weinstock, 2021; Ribero-Vargas, 2025]. See the CKS topics on Anaemia - B12 and folate deficiency and Anaemia - iron deficiency for more information.
- Hypovolaemia and dehydration [Weinstock, 2021; Ribero-Vargas, 2025].
- Orthostatic hypotension; vasovagal episodes; postural orthostatic tachycardia syndrome [Weinstock, 2021; Chua, 2024; Ribero-Vargas, 2025]. See the CKS topic on Blackouts and syncope for more information.
- Phaeochromocytoma [Weinstock, 2021].
- Paget's disease [Chua, 2024].
- Drugs
- Sympathomimetic agents in inhaled beta-2 agonists (such as salbutamol), antimuscarinics (such as ipratropium bromide), and vasodilators (such as hydralazine) [Weinstock, 2021; Chua, 2024; Ribero-Vargas, 2025].
- Theophylline, digoxin, class 1 anti-arrhythmic drugs such as flecainide, corticosteroids, methylphenidate, nasal pseudoephedrine [Wolff, 2009; Gale, 2016; Weinstock, 2021; Chua, 2024].
- Drugs that prolong the QT interval, including non-sedating antihistamines (such as terfenadine), macrolide antibiotics (such as clarithromycin and erythromycin), fluoroquinolone antibiotics, first- and second-generation antipsychotic drugs (such as risperidone), some antidepressant drugs (such as citalopram and escitalopram, tricyclics, and monoamine oxidase inhibitors), and antifungals (such as itraconazole) [Ribero-Vargas, 2025].
- Abrupt withdrawal of beta-blockers Weinstock, 2021 ; Chua, 2024 ; [Weinstock, 2021; Chua, 2024; Ribero-Vargas, 2025].
- Alcohol, caffeine, nicotine, cocaine, heroin, amphetamines, ecstasy, and cannabis [Weinstock, 2021; Chua, 2024].
- Cardiac arrhythmias
Assessment of palpitations
How should I assess a person with palpitations?
- Ask about:
- The onset (sudden or gradual) and circumstances at onset, age at first episode, precipitating factors or triggers, duration, and frequency of palpitations (paroxysmal or persistent).
- Sudden onset and offset of palpitations, and onset associated with exercise, can indicate serious underlying pathology.
- Sustained rapid palpitations of gradual onset and offset over minutes or longer duration may indicate sinus tachycardia.
- The nature of palpitations, including whether they are fast or slow; regular or irregular (ask the person to tap out the rhythm during a typical episode, if possible).
- Associated symptoms that could indicate a serious cause or complication, such as breathlessness, chest pain, and/or syncope or near syncope. See the CKS topic on Blackouts and syncope for more information.
- A history of heart disease that could predispose to a serious arrhythmia, such as:
- Ischaemic heart disease. See the CKS topic on Angina for more information.
- Heart failure. See the CKS topic on Heart failure - chronic for more information.
- Cardiomyopathy.
- Valve disease.
- A family history of heart disease, arrhythmia, or sudden cardiac death under the age of 40 years.
- Any comorbidities, such as:
- Hypertension, diabetes mellitus, obesity, obstructive sleep apnoea syndrome, and thyrotoxicosis may be associated with atrial fibrillation and flutter. See the CKS topics on Atrial fibrillation, Diabetes - type 1, Diabetes - type 2, Hypertension, Hyperthyroidism, Obesity, and Obstructive sleep apnoea syndrome for more information.
- Anaemia may be associated with tachyarrhythmias. See the CKS topics on Anaemia - B12 and folate deficiency and Anaemia - iron deficiency for more information.
- Fever may be associated with ventricular extrasystoles and atrial fibrillation.
- Use of any prescribed or over-the-counter potentially causative drugs, including recent dose changes or withdrawal.
- Lifestyle and psychosocial factors, including insomnia, anxiety, and emotional stress, which may be associated with ventricular extrasystoles or atrial fibrillation. See the CKS topics on Generalized anxiety disorder, Insomnia, and Post-traumatic stress disorder for more information.
- Use of excess alcohol, caffeine, nicotine, and recreational drugs including cocaine, heroin, amphetamines, ecstasy, and cannabis.
- The presence of any other potential systemic causes.
- The impact of palpitations on the person's quality of life and daily functioning.
- The onset (sudden or gradual) and circumstances at onset, age at first episode, precipitating factors or triggers, duration, and frequency of palpitations (paroxysmal or persistent).
- Examine the person:
- Check temperature, heart rate and rhythm, respiratory rate, oxygen saturation level, and blood pressure (lying and standing to assess for a postural drop).
- If the person is systemically unwell or haemodynamically unstable (hypotension and/or tachycardia), see the section on Hospital admission for more information.
- Check height, weight, and body mass index (BMI).
- Assess the heart for location of the apex beat (if displaced laterally and inferiorly, may suggest cardiomegaly) and for heart murmurs suggestive of valvular heart disease.
- Assess for signs of heart failure, such as raised jugular venous pressure (JVP), lung crepitations, and peripheral oedema. See the CKS topic on Heart failure - chronic for more information.
- Assess for signs of comorbidities such as anaemia and thyrotoxicosis. See the CKS topics on Anaemia - B12 and folate deficiency, Anaemia - iron deficiency, and Hyperthyroidism for more information.
- Check temperature, heart rate and rhythm, respiratory rate, oxygen saturation level, and blood pressure (lying and standing to assess for a postural drop).
- If the person has current palpitations, arrange a 12-lead electrocardiogram (ECG) immediately if possible, including a long rhythm strip, to identify the following. See the section on ECG features of common arrhythmias for more information on how to interpret the ECG.
- Ventricular tachycardia (VT) or supraventricular tachycardia (SVT).
- Assume any broad complex tachycardia is VT unless proven otherwise.
- If there is uncertainty about excluding VT or SVT, seek urgent medical advice. Consider forwarding the ECG to a cardiologist for immediate specialist interpretation, or arranging emergency hospital admission, with a copy of the ECG. See the section on Hospital admission for more information.
- Acute ischaemia or acute coronary syndrome. See the CKS topic on Angina for more information.
- Long or short QT interval.
- Short PR interval (pre-excitation/Wolff-Parkinson-White syndrome).
- Atrial fibrillation or flutter. See the CKS topic on Atrial fibrillation for more information.
- Extrasystoles (atrial and ventricular).
- Sinus tachycardia.
- Ventricular tachycardia (VT) or supraventricular tachycardia (SVT).
- If the person has a history of palpitations, arrange a 12-lead ECG, the urgency depending on clinical judgement, to identify the following. See the section on ECG features with an increased risk of arrhythmia for more information.
- Evidence of ischaemic heart disease or previous acute coronary syndrome. See the CKS topic on Angina for more information.
- Left or right ventricular hypertrophy.
- P-wave abnormalities.
- Evidence of pre-excitation/Wolff-Parkinson-White syndrome.
- Long QT syndrome.
- If there is any uncertainty about the interpretation of an ECG, seek specialist advice.
Common arrhythmias on ECG
- Ventricular tachycardia (VT). See a typical trace from the ECG library.
- No obvious P-waves.
- Broad QRS complex (greater than 120 milliseconds [msec]).
- Rate usually greater than 160 beats per minute (bpm).
- Supraventricular tachycardia (SVT). See a typical trace from the ECG library.
- P-waves are usually not identifiable.
- Regular narrow QRS complex (less than 120 msec; unless the person also has a bundle branch block).
- Rate usually between 140 and 280 bpm.
- Long QT interval. See a typical trace from the ECG library.
- The QT interval varies with heart rate.
- A prolonged QT interval (greater than 450 msec) may lead to ventricular tachycardia.
- Wolff-Parkinson-White (WPW) syndrome. See a typical trace from the ECG library.
- Short PR interval (less than 120 msec).
- Slight widening of the QRS complex due to a slurred upstroke (delta wave) of the QRS complex.
- WPW syndrome can cause paroxysmal tachycardia.
- Atrial fibrillation. See a typical trace from the ECG library.
- No distinct P-waves visible.
- There is a varying, completely irregular baseline.
- QRS complex rate is characteristically over 160 bpm without treatment, but can be slower.
- Atrial flutter. See a typical trace from the ECG library.
- P-wave rate 300 bpm producing a saw-tooth pattern.
- Narrow QRS complex (unless the person has a bundle branch block as well).
- 2:1, 3:1, or 4:1 block resulting in QRS rate of approximately 150 bpm, 100 bpm, or 75 bpm. The rhythm is irregular if the block is variable, and may resemble atrial fibrillation.
- Ventricular extrasystoles (ectopics). See a typical trace from the ECG library.
- Early QRS complex.
- No P-wave.
- QRS complex is wide (greater than 120 msec) and abnormally shaped.
- Abnormally shaped T-wave.
- When these alternate with normal QRS complexes, the rhythm is called bigeminy. See a typical trace from the ECG library.
- When extrasystoles occur with every third beat, the rhythm is called trigeminy.
- Atrial extrasystoles (ectopics). See a typical trace from the ECG library.
- No P-wave or an abnormally shaped P-wave.
- Early QRS complex of similar morphology to normal sinus beats.
- Sinus tachycardia. See a typical trace from the ECG library.
- Rate over 100 bpm, normal sinus rhythm.
ECG features with an increased risk of arrhythmia
- Previous myocardial infarction (MI). See a typical trace from the ECG library.
- Pathological Q-waves.
- Inversion of T-waves.
- Loss of R-wave progression across the chest leads following an anterior MI.
- Left bundle branch block following a previous MI.
- Left ventricular hypertrophy. See a typical trace from the ECG library.
- R-wave in V6 greater than 25 mm.
- R-wave in V6 plus S-wave in V1 greater than 35 mm.
- R-wave in I plus S-wave in III greater than 25 mm.
- Inverted T-wave in VL, V5–V6.
- Axis normal or deviated to the left.
- Right ventricular hypertrophy. See a typical trace from the ECG library.
- Tall R-wave in V1.
- T-wave inversion in V1–V3 or V4.
- Deep S-wave in V6.
- Right axis deviation.
- P-wave abnormalities.
- Peaked P-waves occur with right atrial overload caused by pulmonary or tricuspid valve stenosis, or pulmonary hypertension. See a typical trace from the ECG library.
- Broad and bifid P-waves occur with left atrial overload, most commonly caused by hypertension, but classically seen with mitral valve disease.
- Wolff-Parkinson-White (WPW) syndrome. See a typical trace from the ECG library.
- Short PR interval (less than 120 milliseconds [msec]).
- Slight widening of the QRS complex due to slurred upstroke (delta wave) of the QRS complex.
- WPW syndrome can cause paroxysmal tachycardia.
- Long QT interval. See a typical trace from the ECG library.
- The QT interval varies with heart rate.
- A prolonged QT interval (greater than 450 msec) may lead to ventricular tachycardia.
Basis for recommendation
The recommendations on assessment of a person with palpitations are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011], the NHS England publication Getting it right first time. Palpitation referral pathway [NHSE, 2025], online ECG library resources [ECG Library, 2025; LITFL, 2026], and expert opinion in review articles on palpitations [Wolff, 2009; Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
Clinical features on history-taking
- These recommendations are based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [Wolff, 2009; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
- Expert opinion in a review article notes that history-taking is important to help diagnose any underlying cause of palpitations, and may also guide which patients need additional investigations [Weinstock, 2021].
- The EHRA position paper states that exercise-induced palpitations may indicate underlying ischaemic, valvular, or other structural heart disease, and need specialist investigation [Raviele, 2011]. Similarly, expert opinion in a review article states that palpitations occurring with exercise or exertion may indicate a potentially serious cause, such as cardiomyopathy or supraventricular arrhythmia, whereas palpitations occurring at rest may indicate a vagally mediated cause, such as ventricular extrasystoles (Weinstock, 2021)[Weinstock, 2021].
- Palpitations with rapid onset and offset are often due to supraventricular or ventricular tachyarrhythmias. A regular and rapid pounding sensation in the neck may be due to atrioventricular node re-entry tachycardia [Chua, 2024].
- Expert opinion in review articles states that palpitations of longer duration or waking a person from sleep are more likely to be related to an arrhythmia than a non-cardiac cause. Sustained palpitations lasting for minutes or longer, are more commonly associated with supraventricular arrhythmias, ventricular arrhythmias, or anxiety [Weinstock, 2021; Ribero-Vargas, 2025].
- Palpitations which are worse at night may suggest benign ectopy or atrial fibrillation [Weinstock, 2021]. In contrast, palpitations that are very transient and last only a few seconds are more likely to be due to atrial or ventricular extrasystoles (ectopics) (Weinstock, 2021 ; Ribero-Vargas, 2025)[Weinstock, 2021; Ribero-Vargas, 2025].
- A family history of sudden early cardiac death may indicate a genetic arrhythmia syndrome such as congenital long QT syndrome or short QT syndrome, or hypertrophic cardiomyopathy [McLellan, 2019; Weinstock, 2021; Gauer, 2024].
- Expert opinion in a review article notes that anxiety is the most common non-cardiac cause of palpitations [Weinstock, 2021]. The EHRA position paper notes that anxiety can either induce sinus tachycardia or modify a person's subjective perception of a heartbeat that is otherwise normal or which has 'minimal irregularities'. In addition, adrenergic hyperactivation associated with intense emotions and anxiety may, in some cases, predispose a person to supraventricular and/or ventricular arrhythmias [Raviele, 2011].
- The recommendation to assess the impact of palpitations on the person's quality of life and functioning is based on expert opinion in a review article, which also notes that symptom burden will sometimes affect the management strategy offered [McLellan, 2019].
Clinical features on examination
- These recommendations are based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [Wolff, 2009; Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
- Expert opinion in a review article notes that 'physical examination is low yield for diagnosing the cause of palpitations but should be used to guide further workup'. It can help to rule out underlying causes and guide the differential diagnosis in individual patients [Weinstock, 2021].
- Similarly, expert opinion in additional review articles note that as palpitations are usually intermittent and short-lived, a person may be asymptomatic with no clinical signs on examination [Chua, 2024; Ribero-Vargas, 2025].
- Checking the person's pulse can help to identify arrhythmia-induced palpitations. An irregular pulse may suggest a diagnosis of atrial fibrillation or premature ventricular contractions [Weinstock, 2021]. An expert opinion in a review article notes that an abnormal resting heart rate (less than 60 or greater than 100 beats per minute) may correlate with the presence of arrhythmia (McLellan, 2019)[McLellan, 2019].
- Expert opinion in a review article notes that arrhythmias such as ventricular tachycardia typically present with features of haemodynamic compromise [McLellan, 2019].
- The recommendation to check the person's body mass index (BMI) is extrapolated from expert opinion in a review article, which notes that obesity is a risk factor for atrial fibrillation and ischaemic heart disease [McLellan, 2019].
- Assessing for comorbidities such as anaemia or thyrotoxicosis is important, as these may present with sinus tachycardia [McLellan, 2019].
Arranging an electrocardiogram (ECG)
- These recommendations are based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [Wolff, 2009; Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Ribero-Vargas, 2025].
- The EHRA position paper states that 'electrocardiographic documentation of a rhythm disorder during spontaneous symptoms provides the strongest evidence of causality' [Raviele, 2011]. Similarly, expert opinion in a review article states that 'the most important diagnostic test in the approach to a patient with active palpitations is the 12-lead ECG, as it is the reference standard for determining whether the cause of palpitations is arrhythmogenic' [Ribero-Vargas, 2025]. Expert opinion in a further review article states that an ECG may identify the cause of palpitations in 27% of people [Weinstock, 2021].
- The EHRA position paper notes that an ECG recording in the absence of palpitations may provide important data that can suggest the arrhythmic origin of palpitations. Nonetheless, as palpitations are usually transient and the person is often asymptomatic when clinically assessed, there may be uncertainty in establishing a cause-effect relationship between any abnormalities detected and the reported palpitations [Raviele, 2011].
- Similarly, expert opinion in an additional review article notes that performing a 12-lead ECG in between symptoms of palpitations may be helpful, as it may indicate signs of arrhythmogenic or structural heart disease. It highlights, however, that in most cases, the ECG will be normal even if the person has a cardiac aetiology for palpitations [Ribero-Vargas, 2025].
- The recommendation to seek specialist advice if there is any uncertainty about the interpretation of an ECG is based on the NHS England publication [NHSE, 2025]. It is also pragmatic, based on what CKS considers to be good clinical practice.
Management
Scenario: Current palpitations
From age 16 years onwards.
When should I admit a person with current palpitations?
- Arrange emergency admission if a person has current palpitations and:
- Ventricular tachycardia (VT) on ECG.
- Persistent supraventricular tachycardia (SVT) on ECG. Before deciding to admit, if trained and competent to do so, attempt to terminate the SVT if appropriate by:
- Valsalva manoeuvre — for example, ask the person to blow into a 10 mL syringe for 15 seconds.
- Carotid sinus massage —for up to 5 seconds on one side with the neck in an extended position, if there are no contraindications. Ensure that a defibrillator is available, as very rarely terminating an SVT can provoke other arrhythmias. Ideally, record an electrocardiogram (ECG) continuously during and after the procedure.
- Is haemodynamically unstable (with clinically significant hypotension and/or tachycardia).
- High risk structural heart disease, including ischaemic heart disease.
- Features suggestive of a serious underlying cardiac cause or complication:
- Significant breathlessness, chest pain, and/or syncope or near syncope.
- Onset of palpitations precipitated by exercise.
- High-grade or third-degree atrioventricular block on ECG.
- Newly diagnosed atrial fibrillation with a clinically significant tachycardia and/or acute decompensated heart failure. See the CKS topic on Atrial fibrillation for more information.
- A family history of sudden cardiac death under the age of 40 years and/or a known or suspected family history of hypertrophic cardiomyopathy.
- A suspected serious or life-threatening systemic cause, such as severe anaemia, thyrotoxicosis, or sepsis. See the CKS topics on Anaemia - B12 and folate deficiency, Anaemia - iron deficiency, Hyperthyroidism, Neutropenic sepsis, and Sepsis for more information.
Basis for recommendation
The recommendations on hospital admission are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011], the European Society of Cardiology (ESC) guidelines 2019 ESC Guidelines for the management of patients with supraventricular tachycardia [Brugada, 2020], the NHS England publication Getting it right first time. Palpitation referral pathway [NHSE, 2025], and expert opinion in the review articles on palpitations [Wolff, 2009; Gale, 2016] [McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
- The recommendations to consider using the Valsalva manoeuvre or carotid sinus massage to terminate supraventricular tachycardia are based on the ESC guidelines [Brugada, 2020], the NHS England publication [NHSE, 2025], and expert opinion in a review article [McLellan, 2019].
- The ESC guidelines state that the Valsalva manoeuvre is a 'safe and internationally recommended first-line emergency treatment for supraventricular tachycardia', but notes there is limited evidence to support its use in the literature
- The recommendation on if there is a known or suspected family history of hypertrophic cardiomyopathy is extrapolated from expert opinion in a review article, which notes that this condition increases the risk for atrial fibrillation and ventricular tachycardia [McLellan, 2019].
When should I refer a person with current palpitations?
Refer the person to cardiology, the urgency depending on clinical judgement, if hospital admission is not needed and there is:
- Electrocardiogram (ECG) evidence of:
- Atrial flutter.
- Supraventricular tachycardia (SVT) terminated by the Valsalva manoeuvre or carotid sinus massage. See the section on Hospital admission for more information.
- Pre-excitation/Wolff-Parkinson-White syndrome.
- Ventricular extrasystoles (ectopics) where:
- Underlying heart disease is suspected from the clinical assessment and/or ECG.
- Extrasystoles are frequent (such as more than 30 beats in an hour), or ventricular tachycardia (VT) is suspected.
Basis for recommendation
The recommendations on cardiology referral are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011] and expert opinion in review articles on palpitations [Wolff, 2009; Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024].
- Expert opinion in a review article notes that following cardiology referral, an echocardiogram, ambulatory electrocardiogram (ECG) monitoring, and possible electrophysiology studies will be arranged [Weinstock, 2021].
- Expert opinion notes that frequent ventricular extrasystoles of more than 30 beats per hour needs further specialist investigation [Gale, 2016]. CKS notes that what constitutes 'frequent' or 'infrequent' extrasystoles is not widely defined in the literature.
How should I manage a person with palpitations in primary care?
- Reassure the person that hospital admission and urgent cardiology referral are not routinely needed if:
- Palpitations are isolated, and
- The 12-lead electrocardiogram (ECG) is normal, and
- Symptoms are:
- Not provoked by exercise.
- Not associated with lightheadedness, syncope or near syncope, persistent breathlessness, or chest pain.
- Not associated with a history or signs of structural heart disease, heart failure, or hypertension.
- Not associated with a family history of sudden cardiac death under the age of 40 years.
- If a person does not need hospital admission or referral, or is awaiting cardiology assessment following referral:
- Arrange blood tests including a full blood count, urea and electrolytes, thyroid function tests, liver function tests, HbA1c, and lipid profile to help identify any underlying cause, and manage appropriately.
- Consider arranging urine toxicology if there is a history of suspected recreational drug use.
- Perform a cardiovascular risk assessment and manage risk factors appropriately. See the CKS topic on CVD risk assessment and management for more information.
- Advise on lifestyle measures such as reducing or avoiding stress, caffeine, alcohol, smoking, and drugs that can precipitate or exacerbate palpitations.
- If the person has atrial fibrillation, see the CKS topic on Atrial fibrillation for more information on management.
- If the person has sinus tachycardia, assess for and manage any underlying cause where possible.
- If the person has atrial or ventricular extrasystoles (ectopics), if there are no features of underlying heart disease, and palpitations are infrequent, reassure the patient that the palpitations are unlikely to be a cause for concern.
- If palpitations remain poorly controlled, symptomatic, and/or distressing, consider arranging cardiology referral, depending on clinical judgement.
- Give advice about safe driving, work, and leisure activities, if appropriate.
- The Driver and Vehicle Licensing Agency (DVLA) guidance Assessing fitness to drive: a guide for medical professionals provides information on driving restrictions and when to notify the DVLA for Group 1 and Group 2 entitlement drivers with arrhythmia and/or associated symptoms.
- Advise that certain occupations, such as those involving working at height, underwater, or with potentially dangerous machinery, will need to stop work until a diagnosis is confirmed or the underlying condition is treated, and may need an Occupational Health assessment.
- Advise about sources of information and support, such as:
- The NHS (website www.nhs.uk) resources Heart palpitations and Heart rhythm problems (arrhythmia).
- The British Heart Foundation (website www.bhf.org.uk) patient information on Palpitations and Arrhythmias.
- The Arrhythmia Alliance (website www.heartrhythmalliance.org/aa/uk) patient information on Conditions.
Basis for recommendation
The recommendations on management are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011], the Driver and Vehicle Licensing Agency (DVLA) guidance Assessing fitness to drive: a guide for medical professionals [DVLA, 2025], and expert opinion in review articles on palpitations [Wolff, 2009; Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
Offering appropriate reassurance
- These recommendations are based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [Gale, 2016; McLellan, 2019; Chua, 2024].
- If a person has low risk features and referral is not needed, palpitations may be due to extrasystoles or sinus tachycardia [Gale, 2016].
- Expert opinion in a review article states that if a benign cause of palpitations is suspected, appropriate reassurance may markedly reduce symptoms in some people [Chua, 2024].
- CKS notes that what constitutes 'frequent' or 'infrequent' extrasystoles is not widely defined in the literature.
Management in primary care
- The recommendation to arrange blood tests is based on the EHRA position paper, which states that targeted laboratory testing should be arranged only when history and physical examination findings suggest an underlying systemic cause for palpitations, such as hyperthyroidism, anaemia, phaeochromocytoma, or drug use [Raviele, 2011]. This approach is supported by expert opinion in review articles [Gale, 2016; Weinstock, 2021; Chua, 2024; Ribero-Vargas, 2025].
- The recommendation to consider arranging urine toxicology is based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [Weinstock, 2021; Gauer, 2024].
- The recommendations to perform a cardiovascular risk assessment and to advise on lifestyle measures are based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [Chua, 2024; Gauer, 2024].
- The recommendation to manage atrial fibrillation is pragmatic, based on what CKS considers to be good clinical practice.
- The recommendation if a person has atrial or ventricular extrasystoles is based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [McLellan, 2019; Chua, 2024; Gauer, 2024].
Considering cardiology referral
- This recommendation is based on expert opinion in a review article [Weinstock, 2021]. It is also pragmatic, based on what CKS considers to be good clinical practice.
Advising about driving, work, and leisure activities
- The recommendations about safe driving are based on the DVLA publication [DVLA, 2025].
- The recommendations about safe work and leisure activities where symptoms and complications of palpitations have the potential to cause harm to the person or others are based on expert opinion in review articles [Wolff, 2009; McLellan, 2019]. They are also pragmatic, based on what CKS considers to be good clinical practice.
Scenario: History of palpitations
From age 16 years onwards.
When should I refer a person with a history of palpitations?
If a person has a history of palpitations following initial assessment:
- Arrange urgent cardiology referral if the person has:
- A history of syncope or near syncope.
- Palpitations precipitated by exercise.
- A family history of sudden cardiac death under the age of 40 years and/or a known or suspected family history of hypertrophic cardiomyopathy.
- Second- or third-degree atrioventricular block on the 12-lead electrocardiogram (ECG).
- Arrange a routine cardiology referral if the person has:
- Accompanying chest pain or lightheadedness.
- A history or symptoms of structural heart disease, heart failure, or hypertension.
- A resting ECG abnormality, other than second- or third-degree atrioventricular block.
- A history of recurrent sustained tachyarrhythmia, atrial fibrillation, or flutter.
- A history of symptoms that are clearly consistent with paroxysmal supraventricular tachycardia (sudden onset and offset of a fast, regular heartbeat).
- Ventricular extrasystoles (ectopics):
- If underlying heart disease is suspected from the clinical assessment and/or ECG, or
- If extrasystoles are frequent (such as more than 30 beats in an hour) or ventricular tachycardia (VT) is suspected.
- If the person has suspected paroxysmal atrial fibrillation (PAF), see the CKS topic on Atrial fibrillation for more information on management.
- Reassure the person that a cardiology referral is not routinely needed if palpitations are isolated, the 12-lead ECG is normal, and if symptoms are:
- Not provoked by exercise.
- Not associated with lightheadedness, syncope or near syncope, persistent breathlessness, or chest pain.
- Not associated with a history or signs of structural heart disease, heart failure, or hypertension.
- Not associated with a family history of sudden cardiac death under the age of 40 years.
Basis for recommendation
The recommendations on cardiology referral are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011], the NHS England publication Getting it right first time. Palpitation referral pathway [NHSE, 2025], and expert opinion in review articles on palpitations [Wolff, 2009; Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
Arranging urgent cardiology referral
- Expert opinion in a review article recommends cardiology referral if there is a history of structural heart disease, or an abnormal electrocardiogram (ECG) or echocardiogram result. It notes that any management will depend on the arrhythmia mechanism and associated prognosis [McLellan, 2019].
- If there is a history of syncope or pre-syncope, or a known or suspected family history of hypertrophic cardiomyopathy, an echocardiogram may be needed [Weinstock, 2021]. A history of hypertrophic cardiomyopathy increases the risk for atrial fibrillation and ventricular tachycardia. In addition, an implantable loop recorder may be considered for people with sporadic palpitations, for example occurring less than once a month, especially if there is associated syncope [McLellan, 2019].
Arranging routine cardiology referral
- Expert opinion states that specialist cardiology referral should be considered if there is a suspected history of supraventricular tachycardia (SVT) for consideration of electrophysiology studies with or without ablation or implantable loop recorder [McLellan, 2019]. This approach is supported by additional review articles [Gale, 2016; Weinstock, 2021].
- Expert opinion notes that frequent ventricular extrasystoles of more than 30 beats per hour needs further investigation [Gale, 2016]. CKS notes that what constitutes 'frequent' or 'infrequent' extrasystoles is not widely defined in the literature.
How should I investigate a person with a history of palpitations?
- If a person does not need cardiology referral:
- Arrange blood tests, including a full blood count, urea and electrolytes, thyroid function tests, liver function tests, HbA1c, and lipid profile to help identify any underlying cause, and manage or refer appropriately.
- Consider arranging urine toxicology if there is a history of suspected recreational drug use.
- If the cause of the palpitations remains unclear:
- If symptoms are relatively infrequent (less than once a week) and last for an hour or more, advise the person to attend an Emergency department or primary care centre for an electrocardiogram (ECG) during the next episode.
- Provide a letter to be given to the healthcare professional requesting an ECG immediately on presentation during an episode.
- If symptoms are short-lived, arrange ambulatory ECG monitoring in primary care if available, or refer to cardiology. The type of monitoring required depends on the frequency and duration of symptoms:
- If symptoms are short-lived and frequent (for example, at least every 24 hours), a 24-hour or 48-hour Holter monitor may be arranged.
- If symptoms are short-lived and infrequent (for example, less than once a week), a self-activated recorder or a continuous loop event monitor may be needed (usually arranged following cardiology referral).
- Consider use of a patient-activated hand-held ECG device (such as AliveCor KardiaMobile), a smart watch, or other mobile wearable device to record intermittent symptoms, depending on clinical judgement.
- Arrange an echocardiogram in primary care if available, or refer to cardiology, if:
- A murmur is found on examination.
- Heart failure is suspected. See the CKS topic on Heart failure - chronic for more information.
- Structural heart disease is suspected, for example, the ECG shows left bundle branch block, left ventricular hypertrophy, atrial enlargement, or Q-waves.
- There is a greater than 10% burden of ventricular ectopy on ambulatory ECG monitoring.
- If symptoms are relatively infrequent (less than once a week) and last for an hour or more, advise the person to attend an Emergency department or primary care centre for an electrocardiogram (ECG) during the next episode.
Basis for recommendation
The recommendations on investigations are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011], the NHS England publication Getting it right first time. Palpitation referral pathway [NHSE, 2025], and expert opinion in review articles on palpitations [Wolff, 2009] [Gale, 2016; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024; Ribero-Vargas, 2025].
First-line investigations in primary care
- Expert opinion in a review article notes that clinical history, examination, 12-lead electrocardiogram (ECG), and blood tests may identify an underlying cause of palpitations in up to 40% of people [Gale, 2016].
Obtaining an urgent ECG recording if symptomatic
- These recommendations are based on the EHRA position paper [Raviele, 2011] and expert opinion in a review article [Gale, 2016]. They are also pragmatic, based on what CKS considers to be good clinical practice.
Arranging ambulatory ECG monitoring
- Expert opinion in a review article notes that 'the intensity of ambulatory electrocardiographic monitoring and diagnostic work-up will be dictated by the frequency, nature and severity of symptoms, and will sometimes require incorporation of new technologies and electrophysiology referral' [McLellan, 2019].
- Expert opinion in a review article notes that a 2-week continuous loop event monitor has the highest diagnostic yield-to-cost ratio and is the test of choice when arranging ambulatory ECG monitoring. It can, however, miss asymptomatic arrhythmias or arrhythmias associated with syncope, as the person may not activate the recorder during those events. Overall, though, event monitors with remote interpretation of ECG recordings have a considerably higher 'diagnostic yield' than Holter monitor recordings, and the majority of arrhythmia diagnoses are picked up within the first two weeks of wearing continuous loop event monitors [Weinstock, 2021].
- In contrast, Holter monitors have a limited role in the evaluation of palpitations and should only be arranged if typical symptoms reliably occur at least every 24 hours. Holter monitors may also show asymptomatic arrhythmias of clinical significance, and evidence of structural heart disease [Weinstock, 2021].
- Expert opinion in another review article notes that Holter monitors may establish a relationship between patient symptoms and causal rhythm or conduction disorders, but is dependent on reliable symptom diary recording by the person [Ribero-Vargas, 2025].
- Expert opinion in a review article notes that newer technologies such as hand-held ECG or mobile wearable devices may allow an arrhythmia to be captured by the person, but their use may be limited by cost and the time taken to activate the device before the arrhythmia stops [McLellan, 2019].
- Expert opinion in another review article notes that wearable mobile devices are potentially easily accessible and cost-effective. They have variable accuracy and may identify clinically irrelevant abnormalities, however, and may lead to increased testing and overdiagnosis of asymptomatic benign arrhythmias [Weinstock, 2021]. In addition, wearable devices have a high false positive detection rate, and are unable to detect asymptomatic arrhythmias and those of short duration. They show a high sensitivity and specificity for detection of atrial fibrillation, but potentially reduced detection rates for other arrhythmias [Gauer, 2024].
How should I manage a person with a history of palpitations in primary care?
- If a person with a history of palpitations does not need cardiology referral, or is awaiting cardiology assessment following referral:
- Carry out a cardiovascular risk assessment and manage risk factors as appropriate. See the CKS topic on CVD risk assessment and management for more information.
- Advise on lifestyle measures such as reducing or avoiding stress, caffeine, alcohol, smoking, and drugs that can precipitate or exacerbate palpitations.
- If the person has sinus tachycardia, assess for and manage any underlying cause where possible.
- If the person has atrial or ventricular extrasystoles (ectopics), if there are no features of underlying heart disease and palpitations are infrequent, reassure that the palpitations are unlikely to be a cause for concern.
- Arrange referral to cardiology if heart failure or valve disease is confirmed on echocardiogram or if there is uncertainty about the underlying cause, especially if palpitations are sustained, recurrent, and/or distressing.
- Give advice about safe driving, work, and leisure activities, if appropriate.
- The Driver and Vehicle Licensing Agency (DVLA) guidance Assessing fitness to drive: a guide for medical professionals provides information on driving restrictions and when to notify the DVLA for Group 1 and Group 2 entitlement drivers with arrhythmia and/or associated symptoms.
- Advise that certain occupations, such as those working at height, underwater, or with potentially dangerous machinery, will need to stop work until a diagnosis is confirmed or the underlying condition is treated, and may need an Occupational Health assessment.
- Advise about sources of information and support, such as:
- The NHS (website www.nhs.uk) information on Heart palpitations and Heart rhythm problems (arrhythmia).
- The British Heart Foundation (website www.bhf.org.uk) patient information on Palpitations and Arrhythmias.
- The Arrhythmia Alliance (website www.heartrhythmalliance.org/aa/uk) patient information on Conditions.
Basis for recommendation
The recommendations on primary care management are based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011] and expert opinion in review articles [Wolff, 2009; McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024].
Management in primary care
- The recommendation if a person has atrial or ventricular extrasystoles is based on the EHRA position paper [Raviele, 2011] and expert opinion in review articles [McLellan, 2019; Weinstock, 2021; Chua, 2024; Gauer, 2024].
- Expert opinion in a review article notes that if the palpitations are caused by premature atrial or ventricular contractions in the absence of structural heart disease, the person should be reassured that this is a benign condition [Weinstock, 2021]. Similarly, expert opinion in another review article states that if a benign cause of palpitations is suspected, appropriate reassurance may markedly reduce symptoms in some people [Chua, 2024]. CKS notes that what constitutes 'frequent' or 'infrequent' extrasystoles is not widely defined in the literature.
Arranging a cardiology referral
- Expert opinion in a review article states that it is reasonable to consider arranging ambulatory electrocardiogram (ECG) monitoring if there are unexplained palpitations and a person needs reassurance and explanation of their symptoms [Weinstock, 2021]. This approach is supported by expert opinion in an additional review article [McLellan, 2019].
Advising about safe driving, work, and leisure activities
- The recommendations about safe driving are based on the DVLA publication [DVLA, 2025].
- The recommendations about safe work and leisure activities where symptoms and complications of palpitations have the potential to cause harm to the person or others are based on expert opinion in review articles [Wolff, 2009; McLellan, 2019]. They are also pragmatic, based on what CKS considers to be good clinical practice.
Supporting evidence
This CKS topic is largely based on the European Heart Rhythm Association (EHRA) position paper Management of patients with palpitations: a position paper from the European Heart Rhythm Association [Raviele, 2011] and expert opinion in review articles. The rationale for the individual recommendations is discussed in the relevant basis for recommendation sections.
How this topic was developed
This section briefly describes the processes used in developing and updating this topic. Further details on the full process can be found in the About Us section and on the Clarity Informatics website.
Search strategy
Scope of search
A literature search was conducted for guidelines and systematic reviews on primary care management of palpitations.
Search dates
March 2015 - March 2020
Key search terms
The terms listed below are the core search terms that were used for EBSCOhost MEDLINE (searched 30th March 2020). These were combined with filters to identify guidelines, systematic reviews and primary care relevant literature in EBSCOhost MEDLINE. The strategy was adapted for The Cochrane Library databases.
S1 AB palpitation* OR TI palpitation*
Sources of guidelines
- National Institute for Health and Care Excellence (NICE)
- Scottish Intercollegiate Guidelines Network (SIGN)
- Royal College of Physicians
- Royal College of General Practitioners
- Royal College of Nursing
- NICE Evidence
- World Health Organization
- Guidelines International Network
- TRIP database
- Agency for Healthcare Research and Quality
- National Health and Medical Research Council (Australia)
- Royal Australian College of General Practitioners
- British Columbia Medical Association
- Canadian Medical Association
- Alberta Medical Association
- Michigan Quality Improvement Consortium
- Singapore Ministry of Health
- National Resource for Infection Control
- RefHELP NHS Lothian Referral Guidelines
- Medline (with guideline filter)
- Driver and Vehicle Licensing Agency
- NHS Health at Work (occupational health practice)
Sources of systematic reviews and meta-analyses
- The Cochrane Library:
- Systematic reviews
- Protocols
- Database of Abstracts of Reviews of Effects
- Medline (with systematic review filter)
- EMBASE (with systematic review filter)
Sources of health technology assessments and economic appraisals
- NIHR Health Technology Assessment programme
- The Cochrane Library:
- NHS Economic Evaluations
- Health Technology Assessments
- Canadian Agency for Drugs and Technologies in Health
- International Network of Agencies for Health Technology Assessment
Sources of randomized controlled trials
- The Cochrane Library:
- Central Register of Controlled Trials
- Medline (with randomized controlled trial filter)
- EMBASE (with randomized controlled trial filter)
Sources of evidence based reviews and evidence summaries
Sources of national policy
- Department of Health
- Health Management Information Consortium (HMIC)
Patient experiences
Sources of medicines information
The following sources are used by CKS pharmacists and are not necessarily searched by CKS information specialists for all topics. Some of these resources are not freely available and require subscriptions to access content.
Stakeholder engagement
Our policy
The external review process is an essential part of CKS topic development. Consultation with a wide range of stakeholders provides quality assurance of the topic in terms of:
- Clinical accuracy.
- Consistency with other providers of clinical knowledge for primary care.
- Accuracy of implementation of national guidance (in particular NICE guidelines).
- Usability.
Principles of the consultation process
- The process is inclusive and any individual may participate.
- To participate, an individual must declare whether they have any competing interests or not. If they do not declare whether or not they have competing interests, their comments will not be considered.
- Comments received after the deadline will be considered, but they may not be acted upon before the clinical topic is issued onto the website.
- Comments are accepted in any format that is convenient to the reviewer, although an electronic format is encouraged.
- External reviewers are not paid for commenting on the draft topics.
- Discussion with an individual or an organization about the CKS response to their comments is only undertaken in exceptional circumstances (at the discretion of the Clinical Editor or Editorial Steering Group).
- All reviewers are thanked and offered a letter acknowledging their contribution for the purposes of appraisal/revalidation.
- All reviewers are invited to be acknowledged on the website. All reviewers are given the opportunity to feedback about the external review process, enabling improvements to be made where appropriate.
Stakeholders
- Key stakeholders identified by the CKS team are invited to comment on draft CKS topics. Individuals and organizations can also register an interest to feedback on a specific topic, or topics in a particular clinical area, through the Getting involved section of the Clarity Informatics website.
- Stakeholders identified from the following groups are invited to review draft topics:
- Experts in the topic area.
- Professional organizations and societies (for example, Royal Colleges).
- Patient organizations, Clarity has established close links with groups such as Age UK and the Alzheimer’s Society specifically for their input into new topic development, review of current topic content and advice on relevant areas of expert knowledge.
- Guideline development groups where the topic is an implementation of a guideline.
- The British National Formulary team.
- The editorial team that develop MeReC Publications.
- Reviewers are provided with clear instructions about what to review, what comments are particularly helpful, how to submit comments, and declaring interests.
Patient engagement
Clarity Informatics has enlisted the support and involvement of patients and lay persons at all stages in the process of creating the content which include:
- Topic selection
- Scoping of topic
- Selection of clinical scenarios
- First draft internal review
- Second draft internal review
- External review
- Final draft and pre-publication
Our lay and patient involvement includes membership on the editorial steering group, contacting expert patient groups, organizations and individuals.
Evidence exclusion criteria
Our policy
Scoping a literature search, and reviewing the evidence for CKS is a methodical and systematic process that is carried out by the lead clinical author for each topic. Relevant evidence is gathered in order that the clinical author can make fully informed decisions and recommendations. It is important to note that some evidence may be excluded for a variety of reasons. These reasons may be applied across all CKS topics or may be specific to a given topic.
Studies identified during literature searches are reviewed to identify the most appropriate information to author a CKS topic, ensuring any recommendations are based on the best evidence. We use the principles of the GRADE and PICOT approaches to assess the quality of published research. We use the principles of AGREE II to assess the quality of published guidelines.
Standard exclusions for scoping literature:
- Animal studies
- Original research is not written in English
Possible exclusions for reviewed literature:
- Sample size too small or study underpowered
- Bias evident or promotional literature
- Population not relevant
- Intervention/treatment not relevant
- Outcomes not relevant
- Outcomes have no clear evidence of clinical effectiveness
- Setting not relevant
- Not relevant to UK
- Incorrect study type
- Review article
- Duplicate reference
Organizational, behavioural and financial barriers
Our policy
The CKS literature searches take into consideration the following concepts, which are discussed at the initial scoping of the topic.
- Feasibility
- Studies are selected depending on whether the intervention under investigation is available in the NHS and can be practically and safely undertaken in primary care.
- Organizational and Financial Impact Analysis
- Studies are selected and evaluated on whether the intervention under investigations may have an impact on local clinical service provision or national impact on cost for the NHS. The principles of clinical budget impact analysis are adhered to, evaluated and recorded by the author. The following factors are considered when making this assessment and analysis.
- Eligible population
- Current interventions
- Likely uptake of new intervention or recommendation
- Cost of the current or new intervention mix
- Impact on other costs
- Condition-related costs
- In-direct costs and service impacts
- Time dependencies
- Cost-effectiveness or cost-benefit analysis studies are identified where available.
We also evaluate and include evidence from NICE accredited sources which provide economic evaluations of recommendations, such as NICE guidelines. When a recommended action may not be possible because of resource constraints, this is explicitly indicated to healthcare professionals by the wording of the CKS recommendation.
Declarations of interest
Our policy
Clarity Informatics requests that all those involved in the writing and reviewing of topics, and those involved in the external review process to declare any competing interests. Signed copies are securely held by Clarity Informatics and are available on request with the permission of the individual. A copy of the declaration of interest form which participants are asked to complete annually is also available on request. A brief outline of the declarations of interest policy is described here and full details of the policy is available on the Clarity Informatics website. Declarations of interests of the authors are not routinely published, however competing interests of all those involved in the topic update or development are listed below. Competing interests include:
- Personal financial interests
- Personal family interest
- Personal non-financial interest
- Non-personal financial gain or benefit
Although particular attention is given to interests that could result in financial gains or losses for the individual, competing interests may also arise from academic competition or for political, personal, religious, and reputational reasons. An individual is not obliged to seek out knowledge of work done for, or on behalf of, the healthcare industry within the departments for which they are responsible if they would not normally expect to be informed.
Who should declare competing interests?
Any individual (or organization) involved in developing, reviewing, or commenting on clinical content, particularly the recommendations should declare competing interests. This includes the authoring team members, expert advisers, external reviewers of draft topics, individuals providing feedback on published topics, and Editorial Steering Group members. Declarations of interest are completed annually for authoring team and editorial steering group members, and are completed at the start of the topic update and development process for external stakeholders.
Competing interests declared for this topic:
None.
References
- Brugada, J., Katritsis, D.G., Arbelo, E., Arribas, F., et al. (2020) ESC guidelines for the management of patients with supraventricular tachycardia. The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC). European Heart Journal 41(5), 655-720. [Abstract]
- Chua, C.E., Leungsuwan, S., Ng, L.Y. and Teo, D.B.S. (2024) Approach to palpitations in primary care. Singapore Medical Journal 65(7), 405-409. [Abstract]
- DVLA (2025) Assessing fitness to drive: a guide for medical professionals. Driver and Vehicle Licensing Agency. https://www.gov.uk [Free Full-text]
- ECG Library (2025) ECG Library. ECG Library. https://ecglibrary.com/ecghome.php
- Gale, C.P. and Camm, A.J. (2016) Assessment of palpitations. BMJ 352, h5649. [Abstract] [Free Full-text]
- Gauer, R.L., Thomas, M.F. and McNutt, R.A. (2024) Palpitations: evaluation, management, and wearable smart devices. American Family Physician 110(3), 259-269. [Abstract]
- Giada, F. and Raviele, A. (2018) Clinical approach to patients with palpitations. Cardiac Electrophysiology Clinics 10(2), 387-396. [Abstract]
- LITFL (2026) ECG Library. Life In The Fast Lane. https://litfl.com/library [Free Full-text]
- McLellan, A.J. and Kalman, J.M. (2019) Approach to palpitations. Australian Journal of General Practice 48(4), 204-209. [Abstract]
- NHS England (2025) Getting it right first time. Palpitation referral pathway. NHS England. https://gettingitrightfirsttime.co.uk [Free Full-text]
- Raviele, A., Giada, F., Bergfeldt, L., et al. (2011) Management of patients with palpitations: a position paper from the European Heart Rhythm Association. Europace 13(7), 920-934. [Abstract]
- Ribero-Vargas, D., Jaramillo-Alvarez, J.C. and Gandara-Ricardo, J. (2025) Palpitations: a practical approach. Cureus 17(11). [Abstract]
- Weinstock, C., Wagner, H., Snuckel, M. and Katz, M. (2021) Evidence-based approach to palpitations. Medical Clinics of North America 105(1), 93-106. [Abstract]
- Wolff, A. and Cowen, C. (2009) 10 steps before your refer for palpitations. British Journal of Cardiology 16(4), 182-186. [Abstract]