Child health Mental health
Eating disorders
Last revised in July 2024
The main types of eating disorders are:Anorexia nervosa the person maintains a low body weight as a result of a preoccupation with weight
Eating disorders: Summary
- Eating disorders include:
- Anorexia nervosa — low body weight due to restriction of food intake or persistent behaviour which interferes with weight gain and intense fear of gaining weight.
- Bulimia nervosa — recurrent episodes of uncontrolled eating of an abnormally large amount of food over a short time period (binge eating) followed by compensatory behaviour such as self-induced vomiting, laxative abuse, or excessive exercise.
- Binge eating disorder — recurrent episodes of binge eating in the absence of compensatory behaviours. Episodes are marked by feelings of lack of control.
- Atypical eating disorders — closely resemble anorexia nervosa, bulimia nervosa, and/or binge eating but do not meet the precise diagnostic criteria.
- Atypical eating disorders are most common, followed by binge eating disorders, then bulimia nervosa. Anorexia nervosa is the least common.
- Complications associated with eating disorders include:
- Psychological disturbance — anxiety and mood symptoms.
- Social difficulties — disrupted relationships and isolation.
- Family/carer stress.
- Physical abnormalities — musculoskeletal, endocrine, cardiovascular, gastrointestinal, haematological, and dental problems.
- Diagnosis of an eating disorder is based on the person's history and clinical features and is supported, where possible, by corroboration from a relative or friend.
- Clinicians should be aware that assessment may appear normal even in medically unstable people.
- Management of a suspected eating disorder in primary care involves:
- Considering the need for emergency admission if the person is at risk of serious physical or psychological complications such as:
- Severely compromised physical health — BMI or body weight below a safe range, cardiovascular instability, hypothermia, reduced muscle power, concurrent infection, overall ill health or abnormal blood tests.
- Risk of refeeding syndrome.
- Lack of support at home.
- Acute mental health risk — risk of suicide attempt or serious self-harm.
- Referral of all people with a suspected eating disorder to an age-appropriate eating disorder service.
- Urgency of referral depends on the person's circumstances and on clinical judgement.
- While awaiting assessment by the eating disorder team:
- Arranging regular reviews to monitor the level of physical and mental health risk.
- Seeking advice from an appropriate specialist for people with co-morbidities (such as diabetes) and pregnant women.
- Considering the impact of malnutrition and compensatory behaviour on medication effectiveness and risk of side effects.
- Considering the need for emergency admission if the person is at risk of serious physical or psychological complications such as:
- Management of a confirmed eating disorder in primary care involves:
- Ensuring there is a clear agreement between primary and secondary care about responsibility for monitoring a person with an eating disorder.
- Monitoring ongoing levels of risk to the person's mental and physical health and managing complications — specialist input may be indicated.
- Placing an alert in the person’s prescribing record to highlight the potential risk of adverse drug effects.
- Giving advice on contraceptive use and pregnancy to women with eating disorders.
- Ensuring the person and their family/carers have access to information and support.
Have I got the right topic?
From age 12 years onwards.
This CKS topic covers the identification and management of anorexia nervosa, bulimia nervosa, binge eating and atypical eating disorders in primary care.
This CKS topic does not cover obesity or the management of loss of appetite, psychogenic disturbance of appetite or other conditions that involve significant weight loss but which are due to known physical illness. This topic does not cover the following eating disorders pica, rumination disorder, or avoidant/restrictive food intake disorder.
There are separate CKS topics on Bipolar disorder, Depression in children, Depression, Generalized anxiety disorder, Obesity, Obsessive-compulsive disorder, Post-traumatic stress disorder, Psychosis and schizophrenia, and Self-harm.
The target audience for this CKS topic is healthcare professionals working within the NHS in the UK, and providing first contact or primary healthcare.
How up-to-date is this topic?
Changes
July 2024 — reviewed. A literature search was conducted in June 2024 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. No major changes to recommendations have been made.
Previous changes
June 2019 — reviewed. A literature search was conducted in May 2019 to identify evidence-based guidelines, UK policy, systematic reviews, and key RCTs published since the last revision of this topic.
- The information on specialist treatment for eating disorders has been updated based on recommendations in the National Institute for Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2017].
September 2014 to October 2014 — reviewed. A literature search was conducted in September 2014 to identify evidence-based guidelines, UK policy, systematic reviews, and key RCTs published since the last revision of this topic. No significant changes have been made to the recommendations in this topic.
- Following two literature reviews in 2008 and 2011, NICE decided not to update their 2004 guidance on eating disorders [NICE, 2004]. Although new evidence for psychological and pharmacological treatments was identified for eating disorders, this was insufficient to warrant an update or any changes to the recommendations in the NICE guidance [NICE, 2013]. CKS have therefore used the NICE guidelines on eating disorders that were published in 2004 to support the recommendations made in this topic.
July to October 2009 — converted from CKS guidance to CKS topic structure. The evidence-base has been reviewed in detail, and recommendations are more clearly justified and transparently linked to the supporting evidence. There have been no major changes to the recommendations.
November 2005 — minor technical update.
June 2004 — written. Validated in September 2004 and issued in November 2004.
Update
New evidence
Evidence-based guidelines
- BSG (2025) BAPEN Position Statement on Electrolyte and Vitamin Replacement in Adult patients with severe malnutrition, including people with Eating Disorders and other conditions who are undergoing refeeding. British Society of Gastroenterology. [Free Full-text]
HTAs (Health Technology Assessments)
No new HTAs since 1 June 2024.
Economic appraisals
No new economic appraisals relevant to England since 1 June 2024.
Systematic reviews and meta-analyses
No new systematic reviews or meta-analysis which reach the CKS threshold for inclusion since 1 June 2024.
Primary evidence
No new primary evidence which reaches the CKS threshold for inclusion published since 1 June 2024.
New policies
No new national policies or guidelines since 1 June 2024.
New safety alerts
No new safety alerts since 1 June 2024.
Changes in product availability
No changes in product availability since 1 June 2024.
Goals and outcome measures
Goals
To support primary healthcare professionals to:
- Identify people at risk of an eating disorder.
- Make a provisional diagnosis of an eating disorder.
- Refer appropriately for confirmation of diagnosis and specialist management.
- Recognise clinical features requiring urgent admission.
- Monitor a person with a confirmed eating disorder for complications and treat or refer appropriately.
Outcome measures
No outcome measures were found during the review of this topic.Audit criteria
No audit criteria were found during the review of this topic.QOF indicators
No QOF indicators were found during the review of this topic.QIPP - Options for local implementation
No QIPP indicators were found during the review of this topic.NICE quality standards
Eating disorders
- People with suspected eating disorders who are referred to an eating disorder service start assessment and treatment within 4 weeks for children and young people or a locally agreed timeframe for adults.
- People with eating disorders have a discussion with a healthcare professional about their options for psychological treatment.
- People with binge eating disorder participate in a guided self-help programme as first line psychological treatment.
- Children and young people with bulimia nervosa are offered bulimia-nervosa-focused family therapy.
- People with eating disorders who are being supported by more than one service have a care plan that explains how the services will work together.
- People with eating disorders who are moving between services have their risks assessed.
Background information
What is it?
- Eating disorders are characterised by persistent disturbance of eating or eating-related behaviour, which leads to altered intake or absorption of food and causes significant impairment to health and psychosocial functioning.
- The types of eating disorder include:
- Anorexia nervosa – restriction of food intake or persistent behaviour which interferes with weight gain and leads to low body weight. Anorexia nervosa is associated with body image disturbance and an intense fear of gaining weight.
- Bulimia nervosa – recurrent (at least once per week for 3 months) episodes of uncontrolled eating of an abnormally large amount of food over a short time period (binge eating) followed by compensatory behaviour such as self-induced vomiting, laxative abuse or excessive exercise.
- Binge eating disorder — recurrent episodes of binge eating in the absence of compensatory behaviours. Episodes are marked by feelings of lack of control.
- Atypical eating disorders — symptoms of an eating disorder such as anorexia nervosa or bulimia nervosa, which do not meet the precise diagnostic criteria. For example, all of the criteria for anorexia nervosa are met, there is significant weight loss, but the person's weight is within or above normal range. In the 2022 update of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5-TR), atypical eating disorders are classified as:
- Other Specified Feeding or Eating Disorder (OSFED) if they lead to clinically significant distress but do not meet the full criteria for any of the feeding and eating disorders.
- Unspecified Feeding or Eating Disorder (UFED) if they are characterised by disordered eating that is not more accurately captured by OSFED.
- The different types of eating disorders have many features in common, and a person can move between the different diagnostic categories over time.
[Lock, 2015; Bould, 2017a; Rowe, 2017; AED, 2020; Hay, 2020; NICE, 2020; APA, 2022; BMJ Best Practice, 2023a; BMJ Best Practice, 2023b]
What are the causes and risk factors?
- The aetiology of eating disorders is not fully understood but is generally considered to involve a combination of genetic, neurobiological, and sociocultural factors.
- Factors associated with the development and maintenance of an eating disorder include:
- General factors such as female sex, adolescence and early adulthood, and being overweight as a child.
- About 90% of people with an eating disorder are female.
- Neurobiological factors:
- Eating disorders have been associated with abnormal neurotransmitter activity (including serotonin and dopamine) and satiety-related hormones (including adiponectin and ghrelin).
- It is not known if these are involved in the development of an eating disorder or are the result of physiological alterations due to malnutrition.
- Psychosocial factors such as:
- History of sexual abuse.
- Anxiety, depression, neurodivergence, some personality disorders, impulsivity, obsessive/perfectionist traits, low self-esteem, body dissatisfaction, and overestimation of body size.
- Societal idealizations about body shape, including professional or recreational pressure to be slim (for example, in dancing, modelling, and athletics).
- Household stress, social isolation, and poor social support.
- Binge eating disorder is also associated with a history of violence, poverty, trauma, combat, and food insecurity.
- Family history of an eating disorder, psychiatric disorder or substance misuse:
- The risk of developing an eating disorder has been reported as being between 7 to12 times higher in people with a positive family history of eating disorders.
- General factors such as female sex, adolescence and early adulthood, and being overweight as a child.
[Campbell, 2014; Lock, 2015; Zipfel, 2015; Keski-Rahkonen, 2016; Bould, 2017a; RCP, 2019; NICE, 2020; Giel, 2022; BMJ Best Practice, 2023a; BMJ Best Practice, 2023b]
How common is it?
Eating disorders [Zipfel, 2015; Keski-Rahkonen, 2016; Bould, 2017a; RCP, 2019; NICE, 2020; CoSRH, 2021; van Eeden, 2021; Silén, 2022; RCP, 2023]
- Estimates suggest that over 725,000 people in the UK have an eating disorder.
- This is likely to be an underestimate as is based on hospital admission data.
- Eating disorders can develop at any age, but the risk of onset is highest for adolescents and young adults.
- In Western countries, between 5.5% and 18% of young females and 0.6% to 2.4% of young males have experienced a DSM-5-defined eating disorder by early adulthood.
- Between 2015/16 and 2020/21, hospital admissions in England for eating disorders increased by 84%.
- Children and young people exhibited a 90% increased rate of hospital admissions over the five-year period.
- A rise of 128% was observed in boys and young men.
- Adults exhibited a 79% increase over the five-year period.
- Atypical eating disorders are the most common subtype, followed by binge eating disorders, then bulimia nervosa. Anorexia nervosa is the least common.
- A systematic review of 94 studies between 2000-2018 assessed the global prevalence of eating disorders and reported that [Galmiche, 2019]:
- The weighted mean lifetime risk of developing an eating disorder was 8.4% (range 3.3–18.6%) for women and 2.2% (range 0.8–6.5%) for men.
- The point prevalence of eating disorders was 4.6% (range 2.0–13.5%) in America, 2.2% (range 0.2–13.1%) in Europe, and 3.5% (range 0.6–7.8%) in Asia.
- A systematic review of 94 studies between 2000-2018 assessed the global prevalence of eating disorders and reported that [Galmiche, 2019]:
Anorexia nervosa (AN) [Zipfel, 2015; Keski-Rahkonen, 2016; Berends, 2018; NICE, 2020; van Eeden, 2021; BMJ Best Practice, 2023a]
- The lifetime prevalence of AN in women is reported to be between 2–4%.
- Incidence rates vary from 4.2–12.6 per 100,000 person-years for females to 1 per 100,000 for males.
- Overall incidence rates are around 6.0 per 100,000 people, with the highest incidence in people aged 15–19.
- AN has a higher mortality rate than any other mental health disorder.
- The weighted crude mortality rate for AN is around 5.1 deaths per 1,000 person-years. 20% of deaths in people with AN are due to suicide.
Bulimia nervosa (BN) [Lock, 2015; Keski-Rahkonen, 2016; NICE, 2020; BMJ Best Practice, 2023b]
- The prevalence of BN in Europe has been reported as less than 1–2%.
- A systematic review of 94 studies between 2000-2018 assessed the prevalence of eating disorders worldwide and reported that the weighted mean point prevalence for BN was 1.5% (range 0–8.4%) for females and 0.1% (range 0–1.3%) for males [Galmiche, 2019].
- Peak age of onset is in later adolescence and young adulthood (age 15—25 years).
- The weighted crude mortality rate for BN is around 1.74 per 1,000 person-years.
Binge Eating disorder (BED) [Hay, 2014; Galmiche, 2019; NICE, 2020; Giel, 2022; Silén, 2022]
- The estimated lifetime prevalence of BED in Europe is around 1.9% for women and 0.3% for men.
- The worldwide prevalence of BED among adults from 2018-2020 has been estimated at 0.6–1.8% in females and 0.3–0.7% in males.
- BED is identified more often in males and at an older age than other eating disorders — it is often associated with obesity.
Atypical eating disorders (eating disorder not otherwise specified [EDNOS] or other specified feeding or eating disorder [OSFED]) [NICE, 2020]
- Atypical cases form the largest single category of eating disorders.
- A systematic review of 94 studies between 2000-2018 assessed the prevalence of eating disorders and reported that the weighted mean point prevalence for EDNOS was 10.1% (range 0.5–31.1%) for females and 0.9% (range 0–1.7%) for men [Galmiche, 2019].
- The lifetime prevalence of EDNOS in the US is estimated to be around 4.8% in young people and 4.6% in adults.
What are the complications?
Anorexia nervosa
- Complications of anorexia nervosa include:
- Psychological and emotional disturbances such as anxiety, social withdrawal, poor quality of life, low mood, and suicidal ideation.
- Social difficulties such as disrupted relationships, isolation, limitations on employment prospects, and economic disadvantage.
- Family/carer stress — the burden of caring for a person with anorexia nervosa is comparable to that of caring for a person with depression or schizophrenia.
- Physical abnormalities — usually secondary to compromised nutritional state and can affect many systems, including:
- Cardiovascular — arrhythmias, hypotension, valve prolapse, peripheral oedema, sudden death.
- Musculoskeletal — loss of muscle strength, loss of bone density (may be irreversible), fractures, impairment of growth in children and teenagers.
- Endocrine — thyroid abnormalities, incomplete development of secondary sexual characteristics, impaired temperature regulation.
- Gastrointestinal (GI) — slowed GI motility, constipation, upper GI bleeding, abnormal liver function tests, and enlargement of the parotid glands.
- Haematological — low white blood cell count (particularly neutrophils), anaemia (rarely), thrombocytopenia.
- Metabolic — dehydration, electrolyte disturbance in those who misuse laxatives or diuretics or induce vomiting, re-feeding syndrome (a complication of rapid re-feeding treatment).
- Neurological — cognitive impairment, seizures (rarely).
- Renal — kidney stones and acute or chronic kidney disease (chronic volume depletion can lead to the development of kidney disease).
- Dental — erosion of tooth enamel from vomiting.
- Dermatological — dry skin, alopecia, lanugo hair (fine, white hairs), and chilblains.
- Obstetric and gynaecological — infertility (may be irreversible), sexual dysfunction, risk of polycystic ovaries, miscarriage, hyperemesis, anaemia, intrauterine growth restriction, preterm birth, postpartum depression, and anxiety.
- Mortality — most deaths due to anorexia nervosa are a result of the medical consequences of starvation (especially cardiac and severe infection). However, around 20% are due to suicide.
[Mehler, 2015; Zipfel, 2015; Kimmel, 2016; Norris, 2016; Sachs, 2016; Westmoreland, 2016; Bould, 2017a; Wassenaar, 2018; RCP, 2019; NICE, 2020; Treasure, 2020; CoSRH, 2021; BMJ Best Practice, 2023a; RCP, 2023]
Bulimia nervosa
- Complications of bulimia nervosa include:
- Emotional disturbances — mood and anxiety symptoms are very common.
- Social difficulties — low self-esteem and body image disturbance can affect relationships and lead to social isolation.
- Physical abnormalities — can affect many systems, including:
- Cardiovascular — arrhythmias (due to hypokalaemia), diet pill toxicity (for example, palpitations, hypertension), valve prolapse, peripheral oedema.
- Dermatological —knuckle calluses from inducing vomiting (Russell's sign).
- Dental — erosion of tooth enamel from vomiting.
- Endocrine — amenorrhoea, irregular menses, hypoglycaemia, osteopenia.
- Gastrointestinal — acute gastric dilation, oesophageal rupture, Mallory–Weiss tears, parotid gland swelling.
- Metabolic — dehydration, electrolyte imbalance (for example, hypokalaemia), obesity-related complications (around one in three people with bulimia nervosa or binge eating disorder are obese or will become obese).
- Neurological — cognitive impairment (usually related to periods of extreme dieting), peripheral neuropathy.
- Pulmonary — aspiration pneumonitis.
- Renal — renal calculi.
- Obstetric and gynaecological — risk of polycystic ovaries.
- Mortality — the mortality rate associated with bulimia nervosa is lower than that of anorexia nervosa but higher than in people without an eating disorder (due to severe electrolyte imbalance associated with purging behaviours).
[Hay, 2014; Harrington, 2015; Lock, 2015; Kimmel, 2016; Westmoreland, 2016; RCP, 2019; NICE, 2020; Treasure, 2020; BMJ Best Practice, 2023b; RCP, 2023]
Binge eating disorder
- People with binge eating disorder have similar complications to people with bulimia nervosa, although purging carries a greater physical risk than binge eating alone.
- For more information, see the section on Bulimia nervosa.
Atypical eating disorders
- Atypical eating disorders are characterized by symptoms of an eating disorder but do not meet the precise diagnostic criteria for them.
- For example, all of the criteria for anorexia nervosa are met, there is significant weight loss, but the person's weight is within or above normal range.
- If an atypical eating disorder has similar features to the full syndrome of anorexia nervosa, bulimia nervosa or binge eating disorder, the physical and psychosocial complications will be similar.
- For more information, see the sections on Anorexia nervosa, Bulimia nervosa and Binge eating disorder.
What is the prognosis?
Eating disorders can persist for decades if untreated or treated inadequately — illness varies in severity and course over time from person to person.
- Anorexia nervosa [Hay, 2014; Harrington, 2015; Zipfel, 2015; Berends, 2018; RCP, 2019; AED, 2020; NICE, 2020; BMJ Best Practice, 2023a; RCP, 2023]
- The course of anorexia nervosa is very variable — complete recovery is less likely the longer the person has the illness.
- Estimates suggest that 46% of people will fully recover, 34% improve partially, and 20% develop chronic anorexia nervosa.
- Prognosis is best in young people with a short illness duration — up to 60% of adolescents with anorexia nervosa make a full recovery with early specialist treatment.
- Relapse is common.
- A systematic review (n=16 studies) found that 31% of people relapsed after treatment and that the highest risk of relapse was during the first year after discharge.
- Mortality rates are over five times higher for people with anorexia nervosa than the general population.
- Anorexia nervosa has the highest rate of mortality of all mental health disorders.
- The most common causes of death are cardiac complications, severe infection, and suicide (20%).
- The course of anorexia nervosa is very variable — complete recovery is less likely the longer the person has the illness.
- Bulimia nervosa [Harrington, 2015; Lock, 2015; RCP, 2019; NICE, 2020; BMJ Best Practice, 2023b]
- Bulimia nervosa is associated with better recovery rates and lower mortality than anorexia nervosa.
- The course of illness typically consists of cycles of remission and relapse.
- Between 30–60% of people with bulimia nervosa make a full recovery with treatment.
- The reported all-cause standardized mortality ratio for bulimia nervosa ranges from 1.6–1.9.
- Binge eating disorder [Keel, 2010; AED, 2020; NICE, 2020; APA, 2022; Giel, 2022; BMJ Best Practice, 2023a]
- Less is known about binge eating disorder — typically, there are cycles of remission and recurrence with periods (often many months) where the person is free of the eating disorder.
- It is thought that approximately 70–80% of people with binge eating disorders will recover over time (12-year follow-up).
- Atypical eating disorders [AED, 2020; NICE, 2020]
- Prognosis varies widely and depends on the severity of associated physical and psychological features.
- There may be movement between one diagnosis and another — some people with atypical eating disorders may go on to develop bulimia nervosa or, more rarely, anorexia nervosa.
Diagnosis of eating disorders
When should I suspect an eating disorder?
- Suspect an eating disorder in anyone presenting with:
- Unusually low or high BMI for their age (including children with faltering growth).
- Rapid weight loss.
- Changes in eating behaviour, including dieting or restrictive eating practices, are causing concern to the person, their family/carers, or other professionals.
- Mental health problems (such as stress, anxiety and depression) or social withdrawal.
- Disproportionate concern about body weight or shape.
- Poor control of chronic diseases affected by diet (such as diabetes or coeliac disease).
- Menstrual or other endocrine disturbances.
- Unexplained gastrointestinal symptoms, electrolyte imbalance, or hypoglycaemia.
- Physical signs of malnutrition (such as poor circulation, dizziness, palpitations, fainting, or pallor) or compensatory behaviours such as laxative misuse, vomiting, or excessive exercise.
- Note: clinicians are advised to consider parent/carer information (if applicable) during the diagnostic process.
- Be aware that:
- Eating disorders can occur in anyone at any age and may present in people of average or above normal weight.
- Risk in young men and women is highest between 13 and 17 years of age.
- Most people with an eating disorder are of average weight or above, and many go undiagnosed and may present many years after onset.
- A person with an eating disorder may appear well.
- A powerful drive to exercise can override a person's lack of nutritional reserve, and they may appear energetic right up to the point of physical collapse.
- Behaviours associated with eating disorders are often covert.
- Some people may talk openly about an eating disorder, others might be unaware that they have one, or find it too difficult to disclose.
- The person's fear of being advised to gain weight may prevent them from providing an accurate account of their condition.
- Some occupational or recreational activities are associated with a greater risk of eating disorders, such as professional sports, fashion, dance, and modelling.
- Males should be asked about excess training and exercise and misuse of anabolic or androgenic steroids.
- See the section on causes and risk factors for further information.
- Eating disorders may present atypically or with faltering growth or delayed puberty in children and adolescents.
- Other causes must be excluded, but clinicians should have a high index of suspicion in people presenting with weight loss, faltering growth, delayed puberty or menstrual irregularities.
- For more information, see the CKS topic on Faltering growth.
- Eating disorders can occur in anyone at any age and may present in people of average or above normal weight.
- For information on specific clinical features associated with the main eating disorders, see the sections on:
Clinical features of anorexia nervosa
- Restriction of energy intake resulting in low body weight.
- Low weight is defined as less than normal in adults (typically BMI less than 18.5) or minimally expected in children and young people (typically BMI-for-age less than the 5th percentile on an appropriate growth chart).
- Intense fear of gaining weight.
- Preoccupation with food and weight is often related to a pursuit of thinness or, later in the course of illness, a fear of gaining weight.
- Changes in behaviour may be noticed, for example, becoming increasingly selective about food, avoiding eating with others, saying they aren't hungry, that they have already eaten, or refusing food they used to enjoy.
- Other behaviours may include repeated weighing, measuring and checking in the mirror.
- Behaviour that interferes with weight gain.
- Compensatory behaviours such as self-induced purging (by vomiting or misuse of laxatives), excessive exercise, and use of appetite suppressant medication or diuretics may be present.
- Psychological disturbance, which may include:
- Distortion of body image, with a dread of being overweight.
- Low self-esteem and a drive for perfection.
- Over-evaluation of self-worth in terms of body weight and shape.
- Denial of the seriousness of malnutrition and its impact on physical health.
- Many people with anorexia nervosa have difficulty acknowledging there is a problem, do not consider themselves to be ill and may be ambivalent about change.
- In others, there may be secrecy about the symptoms, such as hiding weight loss.
- Hormonal disturbance.
- Females with anorexia nervosa may present with amenorrhoea or other menstrual irregularities.
- Hormonal disturbance is a common feature of anorexia nervosa. Amenorrhea is no longer in the criteria for diagnosis in females and is only one of several markers of hormonal insufficiency due to low weight.
- Males with anorexia nervosa may present with loss of libido and potency.
- In children, the onset of puberty, growth and physical development can be affected.
- Many physical signs are associated with anorexia nervosa, including dry skin, hair loss, bradycardia, orthostatic hypotension, hypothermia, loss of muscle strength, oedema, constipation, fainting, dizziness, and fatigue.
- For more information, see the section on Complications.
Clinical features of bulimia nervosa
- Recurrent episodes of binge eating occurring on average at least once a week for 3 months.
- A binge is defined as consuming excessive food in a discrete time, accompanied by a sense of loss of control over eating at that time.
- In between binges, there are also typically continuing attempts to restrict eating.
- Recurrent inappropriate compensatory behaviour to prevent weight gain (occurring on average at least once a week for 3 months).
- Compensatory behaviours include vomiting, purging, fasting, excessive exercise, laxatives, diuretics or diet pill use.
- Weight is often within normal limits or above the weight range for age.
- Bulimia nervosa may be kept secret for many years, as the person’s appearance is typically unremarkable, and they can often eat normally in public.
- Many people delay seeking help because of the shame associated with binge eating or because they do not know that treatment is available.
- Psychological features, which may include:
- Over-evaluation of self-worth in terms of body weight and shape.
- Fear of gaining weight, with a sharply defined weight threshold set by the person.
- Mood disturbance and symptoms of anxiety and tension.
- Persistent preoccupation and craving for food and feelings of guilt and shame about binge eating.
- Self-harm, often by scratching or cutting.
- Physical symptoms, such as bloating, fullness, lethargy, gastro-oesophageal reflux, abdominal pain, and sore throat (from vomiting).
- In severe cases, physical signs may include Russell's sign (knuckle calluses from inducing vomiting), dental enamel erosion, and salivary gland enlargement.
- For more information, see the section on Complications.
Clinical features of binge eating disorder
- Recurrent episodes of binge eating (at least once per week for 3 months) in the absence of compensatory behaviours.
- A binge is defined as consuming an excessive amount of food in a discrete time period accompanied by a feeling of loss of control where the person cannot stop eating or control the amount of food they eat at that time.
- During a binge, the person may eat more rapidly than normal, eat until uncomfortably full or when not hungry and experience significant distress and feelings of guilt and shame.
- Body weight may be maintained at normal, overweight or obese.
- Many people with binge eating disorder are overweight or obese.
Clinical features of atypical eating disorders
- Atypical eating disorders have features that closely resemble but do not meet the strict criteria for other diagnostic categories. For example, the person's weight may be just above the diagnostic threshold for anorexia nervosa, or binge eating/purging may occur infrequently.
- The majority of eating disorders are atypical.
- Over-concern with body weight and shape is generally present.
- Many people with atypical eating disorders have had anorexia or bulimia nervosa previously or may go on to develop the full diagnostic criteria for anorexia or bulimia nervosa.
Basis for recommendation
The information on the clinical features of eating disorders is derived from the Diagnostic and Statistical Manual of mental disorders: DSM-5-TR [APA, 2022], the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management [RCP, 2023] and Position statement on early intervention for eating disorders [RCP, 2019], the National Institute of Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020], the BMJ Best Practice guidelines Anorexia nervosa [BMJ Best Practice, 2023a] and Bulimia nervosa [BMJ Best Practice, 2023b], the Royal Australian and New Zealand College of Psychiatrists Clinical practice guidelines for the treatment of eating disorders [Hay, 2014], the American Academy of Child and Adolescent Psychiatry (AACAP) Practice parameter for the assessment and treatment of children and adolescents with eating disorders [Lock, 2015], and expert opinion in review articles [Campbell, 2014; Zipfel, 2015; Montano, 2016; Allison, 2017; Rowe, 2017; Wassenaar, 2018; Hay, 2020; Giel, 2022].
How should I assess a person with a suspected eating disorder?
Diagnosis of an eating disorder is based on suggestive clinical features supported, where possible, by corroboration from a relative/carer or friend. Be aware that:
- Eating disorders can be difficult to detect in primary care as those affected may be slow to present, reluctant to disclose symptoms or unaware they have an eating disorder.
- Clinicians should be aware of the sensitivity required to discuss a person's weight and appearance.
- A variety of tools can be used for screening and risk assessment, such as:
- A baseline eating disorder assessment tool available on the National Institute of Health and Care Excellence (NICE) website.
- The SCOFF questionnaire — two or more positive answers to the following questions are suggestive of anorexia nervosa or bulimia nervosa.
- 'Do you ever make yourself sick because you feel uncomfortably full?'
- 'Do you worry that you have lost control over how much you eat?'
- 'Have you recently lost more than one stone in a 3-month period?'
- 'Do you believe yourself to be fat when others say you are too thin?'
- 'Would you say that food dominates your life?'
- Checklist and risk assessment framework from the Royal College of Psychiatrists, which list clinical features suggestive of low, moderate and high risk in anorexia nervosa:
- DSM-5-TR criteria.
- Assessment may be normal even in medically unstable people.
- Severe malnutrition and purging behaviours can lead to life-threatening complications such as cardiovascular instability or severe electrolyte disturbance.
- Primary care clinicians should have a low threshold for seeking advice – emergency admission may be required.
Take a history asking about:
- Symptoms of eating disorders such as:
- Change in weight (increase, decrease, or failure to thrive).
- Dietary restriction or binge eating.
- Fear of gaining weight and body image disturbance — ask about perceived ideal weight.
- Compensatory behaviours (such as excessive exercise, purging, vomiting or use of weight loss medications) — consider insulin misuse in diabetic patients.
- Complications of eating disorders such as fatigue, constipation, reflux, hair loss, and amenorrhoea.
- Be alert for symptoms suggestive of a serious complication requiring urgent admission, such as syncope, pre-syncope, or severe abdominal pain.
- Co-morbidities and symptoms suggestive of an alternative cause, such as inflammatory bowel disease or coeliac disease.
- Mental health
- Mood disorders (such as anxiety, obsessive-compulsive disorder, and depression) and social withdrawal are often associated with eating disorders.
- Assess the risk of self-harm and suicide – for more information, see the CKS topics on Depression, Depression in children and Self-harm.
- Approximately 20% of deaths in people with anorexia nervosa are due to suicide.
- Social history and social support including:
- Stressors at school, work or home (including the internet and social media) – consider possibility of bullying and abuse.
- For more information, see the CKS topic on Child maltreatment - recognition and management.
- Alcohol and drug misuse.
- Stressors at school, work or home (including the internet and social media) – consider possibility of bullying and abuse.
- Family history of eating disorders, depression, or substance abuse.
- Medication (including over-the-counter).
Examine the person:
- Calculate the person's body mass index (BMI) and compare with previous recordings.
- Use centile charts if the person is younger than 18 years of age — it is important to make an early diagnosis in children because they are at risk of irreversible growth impairment.
- Be aware that some people may refuse to be weighed or falsify their weight by drinking large amounts of water beforehand or by hiding heavy objects in their clothes.
- Check vital signs, including:
- Temperature (hypothermia is a red flag).
- Pulse (bradycardia, for example, <50 beats per minute or postural tachycardia are red flags).
- Blood pressure checking for postural differences (hypotension or orthostatic hypotension are red flags).
- Hydration status.
- Peripheral circulation.
- Look for muscle wasting and assess muscle strength:
- Scores of 2 or less (especially if scores are falling) on the Sit up–Squat–Stand (SUSS) test are a red flag.
- The sit up test — the person lies flat on a firm surface such as the floor and has to sit up without, if possible, using their hands.
- The squat test — the person is asked to rise from a squatting position without, if possible, using their hands.
- The Royal College of Psychiatrists offers advice on carrying out these tests.
- Scores of 2 or less (especially if scores are falling) on the Sit up–Squat–Stand (SUSS) test are a red flag.
- Carry out a general examination looking for complications of eating disorders or signs suggestive of an alternative cause.
Consider the need for investigations:
- Extensive investigation is not usually required in primary care. Most people with an eating disorder will have normal blood results which are a poor indicator of risk, however, some tests may be useful to rule out complications.
- Depending on clinical situation, consider the following investigations in primary care (seeking specialist advice or admitting to hospital may be more appropriate):
- Full blood count — may show anaemia from malnutrition or gastrointestinal losses, or mild leucopenia or thrombocytopenia from malnutrition.
- Erythrocyte sedimentation rate (ESR) — usually normal in people with anorexia, a raised ESR may indicate an organic cause of weight loss.
- Urea and electrolytes — hypokalaemia is suggestive of vomiting or laxative abuse; hyponatraemia may be a result of excess water intake. Electrolytes may be elevated due to dehydration.
- Liver function tests — may be slightly elevated from malnutrition.
- Blood glucose.
- Creatinine and urinalysis — chronic hypokalaemia and chronic volume depletion can lead to the development of kidney disease.
- Electrocardiography (ECG) — this should be considered for all people with rapid weight loss, excessive exercise, severe purging behaviours (such as laxative or diuretic use or vomiting), bradycardia, hypotension, excessive caffeine (including from energy drinks), prescribed or non-prescribed medications, muscle weakness, electrolyte imbalance, or previous abnormal heart rhythm.
- Further tests may be required in more severe cases or to assess complications (seek specialist advice):
- Calcium, magnesium, phosphate.
- B12, folate, and ferritin.
- Thyroid function tests.
- Follicle-stimulating hormone, luteinising hormone, oestradiol, prolactin, and urinalysis (including pregnancy test) may be considered if presenting with amenorrhoea.
- Other investigations may be indicated if an alternative diagnosis is suspected (for example, coeliac screening).
Basis for recommendation
The recommendations on how to assess a person with a suspected eating disorder are based on the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management [RCP, 2023], the National Institute of Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020], the BMJ Best Practice guidelines Anorexia nervosa [BMJ Best Practice, 2023a] and Bulimia nervosa [BMJ Best Practice, 2023b], the Royal Australian and New Zealand College of Psychiatrists Clinical practice guidelines for the treatment of eating disorders [Hay, 2014], the American Academy of Child and Adolescent Psychiatry (AACAP) Practice parameter for the assessment and treatment of children and adolescents with eating disorders [Lock, 2015], and expert opinion in review articles [Campbell, 2014; Zipfel, 2015; Montano, 2016; Allison, 2017; Bould, 2017b; Bould, 2017a; Rowe, 2017; Wassenaar, 2018; Hay, 2020; Giel, 2022].
Assessment may be normal even in acutely unwell people
- Clinical guidance from the Royal College of Psychiatrists [RCP, 2023], and NICE [NICE, 2020], highlight the fact that medically unstable people with anorexia nervosa and bulimia nervosa can appear deceptively well:
- No one parameter is a good indicator of overall level of risk or illness.
- Primary care clinicians should carry out a thorough clinical assessment and have low threshold for seeking specialist advice (for example on the need for admission) [Bould, 2017a; RCP, 2023].
- The Royal College of Psychiatrists has provided a detailed list of parameters to help ascertain level of risk (low, moderate and high risk) in eating disorders [RCP, 2023].
- Be aware that normal and cut-off physiological parameters, such as blood pressure, vary with age, and danger thresholds differ significantly for children and adults.
Collateral history
- Guidance from the American Psychiatric Association [APA, 2022], Royal Australian and New Zealand College of Psychiatrists [Hay, 2014] and NICE [NICE, 2020] and expert opinion in a review article [Bould, 2017b] recommend where possible (if not contraindicated or refused by the person) getting a collateral history from sources such as family members and other clinicians involved in the person’s care.
- Input from others is especially helpful as people with eating disorders may be reluctant to disclose information, minimise symptoms and/or have poor insight into their condition.
- Respect Gillick competence if a young person under 16 does not want family members or carers involved [NICE, 2020].
Screening tools
- NICE recommend that screening tools (such as SCOFF) should not be used as the sole method of identifying an eating disorder [NICE, 2020].
Ask about co-morbidities
- Other mental health disorders
- Expert opinion in guidelines [Hay, 2014; RCP, 2019; NICE, 2020; RCP, 2023] and review articles [Harrington, 2015; Zipfel, 2015; Bould, 2017a] is that people with suspected eating disorders must be assessed for mood disorders, substance misuse, and risk of self-harm or suicide.
- Up to 75% of people with anorexia nervosa are reported to have an associated mood disorder (most commonly depression), 5–75% have a history of at least one anxiety disorder and obsessive-compulsive disorder occurs in 15–29% [Zipfel, 2015].
- Approximately 20% of deaths in people with anorexia nervosa are due to suicide [NICE, 2020].
- Diabetes
- People with diabetes who have an eating disorder are at increased risk of serious complications. Guidance from NICE recommends risk management as the first consideration [NICE, 2020].
Investigations
- The recommendations on which investigations to consider in primary care are based on clinical guidelines [RCP, 2023; NICE, 2020; Hay, 2014], and expert opinion in review articles [Zipfel, 2015; Bould, 2017a; Rowe, 2017; Wassenaar, 2018].
- As many test results remain normal even with extreme weight loss and when the person is acutely unwell a low threshold for seeking advice on further assessment or the need for admission to hospital is required.
What else might it be?
- The differential diagnoses of weight loss include:
- Malabsorption, for example, coeliac disease, inflammatory bowel disease or peptic ulcer.
- Malignancy.
- Drug or alcohol misuse.
- Infection, for example, tuberculosis, HIV, and infectious mononucleosis.
- Autoimmune disease, including rheumatological disorders.
- Endocrine disorders, for example, hyperthyroidism, diabetes mellitus, hypercortisolism, and adrenal insufficiency.
- The differential diagnoses that can underlie compulsive eating include:
- Cushing's disease.
- Hypothyroidism.
- Insulinoma.
- Neurological disorders (lesions of the medial hypothalamus or craniopharyngioma).
- Prader-Willi syndrome.
- The differential diagnoses of amenorrhoea include:
- Pregnancy.
- Primary ovarian failure.
- Polycystic ovary syndrome.
- Pituitary prolactinoma.
- Hypothalamic causes.
- The psychiatric differential diagnoses include:
- Depression.
- Anxiety.
- Obsessive-compulsive disorder.
- Body dysmorphic disorder.
- Substance misuse.
- Psychosis or schizophrenia.
- Borderline personality disorder.
- Bipolar disorder.
Basis for recommendation
The information on the differential diagnoses of eating disorders is based on the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management [RCP, 2023], the BMJ Best Practice guidelines Anorexia nervosa [BMJ Best Practice, 2023a] and Bulimia nervosa [BMJ Best Practice, 2023b], the American Academy of Child and Adolescent Psychiatry (AACAP) Practice parameter for the assessment and treatment of children and adolescents with eating disorders [Lock, 2015], and expert opinion in review articles [Campbell, 2014; Bould, 2017b; Bould, 2017a; Treasure, 2020; Giel, 2022].
Management
Scenario: Suspected eating disorder
From age 12 years onwards.
How should I manage a suspected eating disorder in primary care?
- Consider the need for emergency medical or psychiatric admission for anyone at risk of serious physical complications, suicide or serious self-harm.
- For all other people with a suspected eating disorder:
- Refer immediately to an age-appropriate eating disorder service for specialist assessment and management – do not use a watchful waiting strategy for managing eating disorders.
- Depending on locally agreed care pathways and service provision referral may be to a community mental health team (CMHT), child and adolescent services (CAMHS), or a specialist eating disorder unit.
- Consider simultaneous paediatric referral for children and young people with eating disorders.
- Urgency of referral depends on the specific clinical situation and on clinical judgement — if unsure seek advice from the nearest specialist eating disorders service, eating disorders or liaison psychiatry clinician, the local CAMHS service, or a paediatrician/physician (as appropriate).
- While awaiting specialist assessment:
- Arrange regular review (with frequency dependant on the clinical situation [for example, weekly in children]) to monitor levels of physical and mental health risk and consider the need for urgent admission, further investigations, or increasing the urgency of referral.
- Consider the possibility of complications and monitor/manage appropriately, seeking specialist advice when indicated.
- Ensure that people with co-morbidities (such as diabetes) or pregnant women have specialist input — increased monitoring and alterations to treatment may be required.
- When prescribing medication for people with a suspected eating disorder, take into account the impact of malnutrition and compensatory behaviour on medication effectiveness (for example, the oral contraceptive pill) and the risk of side effects (in particular, cardiac side effects).
- Refer immediately to an age-appropriate eating disorder service for specialist assessment and management – do not use a watchful waiting strategy for managing eating disorders.
Basis for recommendation
The recommendations on management of suspected eating disorders in primary care are largely based on the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management [RCP, 2023], the National Institute of Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020], the American Academy of Child and Adolescent Psychiatry (AACAP) Practice parameter for the assessment and treatment of children and adolescents with eating disorders [Lock, 2015], and expert opinion in review articles [Campbell, 2014; Harrington, 2015; Bould, 2017b; Bould, 2017a; Rowe, 2017].
Consider the need for admission
- Complications of eating disorders can be life-threatening and people with anorexia nervosa or bulimia nervosa can deteriorate quickly. Clinical guidelines emphasise the need for early recognition of physical and mental health compromise and emergency specialist treatment [NICE, 2020; RCP, 2023].
Early recognition and referral
- The Royal College of Psychiatrists and NICE recommend early referral to eating disorder services as recovery rates are better and risk of relapse reduced with early intervention [RCP, 2019; NICE, 2020].
Managing complications while awaiting referral
- This recommendation is based on what CKS considers to be good clinical practice.
When should I admit a person with a suspected or confirmed eating disorder?
- Be aware that some medically unstable people with eating disorders can appear deceptively well – a low threshold for concern is essential. If there is uncertainty, seek specialist advice from an eating disorders or liaison psychiatry clinician, the local CAMHS service, or a paediatrician/physician (as appropriate).
- Clinicians are strongly encouraged to review the detailed information on parameters that indicate level of risk from the Royal College of Psychiatrists.
- Consider emergency admission for anyone at risk of serious physical or psychological complications such as:
- Severely compromised physical health, including:
- BMI or body weight below a safe range—the degree of dietary restriction and rate of weight loss are important; for example, more than 1kg per week indicates high risk.
- Cardiovascular instability, for example, bradycardia of 40 beats or less per minute), tachycardia on standing, prolonged QT interval on ECG, or hypotension (including postural).
- Hypothermia.
- Reduced muscle power on the Sit up–Squat–Stand (SUSS) test.
- Concurrent infection.
- Overall ill health or rapid deterioration.
- Abnormal blood tests such as electrolyte imbalance or hypoglycaemia.
- Risk of refeeding syndrome:
- Risk is increased by rapid weight loss, fasting for over five days, BMI less than 16kg/m2, compensatory behaviours (such as laxative misuse or vomiting), dehydration, use of diet pills or diuretics, water loading or excessive exercise.
- Acute mental health risk (such as risk of suicide attempt or serious self-harm):
- Consider psychiatric crisis care or psychiatric inpatient care – discuss with a specialist if unsure whether admission to medical/paediatric ward is more appropriate.
- Lack of support at home:
- Consider admission if the person may not be kept from significant harm at home or where the home environment impedes recovery.
- Severely compromised physical health, including:
- If unsure where to admit (for example acute psychiatric ward, specialist eating disorders unit or acute medical/paediatric ward) discuss with a specialist.
- The most appropriate place to admit a person with a life-threatening eating disorder is not always obvious and depends on local services and practice.
- Children and adolescents should be admitted to age-appropriate facilities.
- If a person's physical health is at serious risk due to their eating disorder and they can only be treated safely as an inpatient but they do not consent to admission:
- Consider the need for compulsory admission and seek specialist advice.
Basis for recommendation
The recommendations on when to admit a person with a suspected or confirmed eating disorder are based on the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management [RCP, 2023], the National Institute of Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020], the American Academy of Child and Adolescent Psychiatry (AACAP) Practice parameter for the assessment and treatment of children and adolescents with eating disorders [Lock, 2015], the Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of eating disorders [Hay, 2014] and expert opinion in review articles [Harrington, 2015; Allison, 2017; Bould, 2017b; Wassenaar, 2018].
- NICE states that there is no international agreement on admission criteria for in-patient care and that thresholds specified vary [NICE, 2020].
- Patients with extreme medical risk and organ failure are usually admitted to general medical wards. In the UK, the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management provides advice regarding optimisation of management, and liaison between physical and psychiatric care [RCP, 2023].
- Clinical guidelines agree that single parameters should not be used in isolation to determine the need for admission — no one parameter is a good indicator of overall level of risk or illness, thorough clinical assessment is essential [NICE, 2020; RCP, 2023].
- Medically unstable people with an eating disorder can appear deceptively well – the most medically unstable patients can have a normal weight.
- Changes over time which may indicate rapid decline must be considered.
Risk of re-feeding syndrome
- The information on factors associated with increased risk of refeeding syndrome are from the NICE guidance on eating disorders [NICE, 2020].
Where to admit
- Guidance from NICE and the Royal College of Psychiatrists acknowledges that there is wide variation in availability of services in different areas. The best place to admit depends on the clinical state of the patient as well as the services available locally — discussion with local the eating disorders team is indicated [NICE, 2020; RCP, 2023].
Compulsory admission
- Guidance from NICE and the Royal College of Psychiatrists states that some people with eating disorders may require in-patient treatment and may be putting their lives at risk if they refuse this. In such situations, the person can be admitted under the appropriate section of the Mental Health Act and treated against their will [NICE, 2020; RCP, 2023].
Mental Health Act 1983 (amended 2007)
- The Mental Health Act allows compulsory admission and treatment of people who:
- Have a mental disorder of a nature and degree that warrants treatment in hospital, and
- Need to be admitted in the interests of their own health or safety, or for the protection of other people.
- Compulsory admission is arranged using the appropriate section of the Mental Health Act:
- Section 2 allows compulsory admission for up to 28 days for assessment.
- Section 3 allows compulsory admission for up to 6 months for treatment (in people with an established diagnosis).
- Sections 2 and 3 require an application from an Approved Mental Health Professional (AMHP, formerly an Approved Social Worker) or, rarely, the person's nearest relative, and recommendations from two doctors, one of whom is section 12-approved (usually a psychiatrist) and one who has previous acquaintance with the person (usually the person's GP if at all practicable).
- Ideally, the person should be examined jointly by the two doctors with the AMHP also present. Where this is not possible, each doctor may carry out a separate examination. If the AMHP is not present, at least one of the doctors must discuss the person with the AMHP.
- Section 4 is used in exceptional cases to permit compulsory admission for up to 72 hours if there is an urgent necessity and an undesirable delay occurs while trying to arrange admission under section 2.
- It requires an application from an AMHP (or, rarely, the person's nearest relative) and just one medical recommendation, preferably from a doctor with previous acquaintance (usually the person's GP).
- Section 136 is used by police to take people from a public place to a place of safety to enable examination by a registered medical practitioner and interview by an AMHP. The person's GP, where known, may be informed.
- Details of guidance and forms for the most common sections of the Mental Health Act can be accessed from the Department of Health website, as well as details of amendments made in the Mental Health Act 2007.
Scenario: Confirmed eating disorder
From age 12 years onwards.
How should I manage someone with a confirmed eating disorder in primary care?
- Ensure there is a clear agreement between primary and secondary or tertiary care about the responsibility for monitoring a person with an eating disorder.
- Monitoring of general medical problems usually occurs in primary care.
- Good coordination of care is essential when young people move from child to adult services if more than one service is involved in care or care is needed in different places at different times (for example, university students).
- For people who are being treated in secondary care — monitor the level of risk to the person's mental and physical health as treatment progresses.
- Be aware that medically unstable people with eating disorders (such as anorexia nervosa and bulimia nervosa) can appear deceptively well.
- Risk may increase, for example following weight change or at times of transition between services — consider the need for admission or increased specialist input.
- Monitor growth and development closely in children and young people with anorexia nervosa who have not completed puberty — discuss with a specialist if unsure.
- If the person has chronic anorexia nervosa and is not receiving ongoing treatment in secondary care, review their physical and mental health at least annually in primary care.
- A baseline assessment tool is available on the NICE website.
- Review should include discussion of treatment options and:
- Weight or BMI (using centile charts where appropriate).
- Blood pressure.
- Relevant blood tests.
- Discussion of problems with daily function.
- ECG for people with purging behaviours and/or significant weight changes.
- Assessment of risk (both physical and mental health).
- If the person exhibits compensatory behaviours such as:
- Vomiting — give advice on the importance of regular dental and medical review. They should:
- Avoid brushing their teeth immediately after vomiting. This can brush acid onto the teeth, causing further damage.
- Rinse with water or a non-acidic mouthwash after vomiting.
- Reduce the acidity of the oral environment (for example, by avoiding acidic foods and drinks).
- Misuse of laxatives or diuretics — advise them that:
- Laxatives and diuretics do not reduce calorie absorption and do not help with weight loss — laxative or diuretic use should be gradually reduced and stopped.
- Excessive exercise — advise them to stop.
- Vomiting — give advice on the importance of regular dental and medical review. They should:
- Put an alert in the person’s prescribing record to highlight the potential risk of adverse drug effects.
- Adverse drug effects, such as prolonged QT interval and cardiac dysrhythmias, are more likely in malnourished people and those with electrolyte abnormalities — review all drugs prescribed to people with an eating disorder.
- Offer ECG monitoring to people with an eating disorder who are taking medication that can compromise cardiac functioning, for example, drugs that may cause electrolyte imbalance, bradycardia, hypokalaemia, or a prolonged QT interval.
- Be aware that paracetamol toxicity can be caused by a low body weight. For example, ingestion of 7.5 g of paracetamol over 24 hours in a person weighing 30 kg can lead to severe toxicity. For more information, consult Toxbase.
- Manage complications (considering other causes) depending on their type and severity.
- Some people will require inpatient or specialist outpatient care while others can be managed in primary care— seek advice if unsure.
- For suspected developmental delay or faltering growth in children and young people with an eating disorder, seek specialist paediatric advice.
- If low bone mineral density is suspected — discuss bone density scanning and treatment with the eating disorder team. Advise people with anorexia nervosa and osteoporosis/related bone disorders to avoid activities that are high-impact or significantly increase the chance of falls or fractures.
- For information on identifying, assessing and managing obesity, see the CKS topic on Obesity.
- Manage comorbidities with input from specialists where appropriate, for example:
- Diabetes — insulin may be misused in people with eating disorders. Close monitoring and collaboration between the eating disorder and diabetes teams is required — have a low threshold for checking blood glucose and ketones and seeking specialist advice.
- Associated mental health problems and substance abuse – seek specialist advice.
- Be aware that women with an eating disorder:
- Who are sexually active should be advised of the risk of unplanned pregnancy and the need for effective contraception even if they have amenorrhoea.
- Long-acting reversible contraception (LARC) methods (such as implant and intra-uterine contraceptives) are most effective in this group.
- Implants should only be fitted by experienced clinicians as some women with eating disorders may have little subcutaneous tissue.
- Consideration of the UK Medical Eligibility Criteria for contraceptive use (UKMEC) is required – for more information, see the CKS topic on Contraception - assessment.
- Anorexia nervosa is a significant risk factor for osteoporosis — use of progesterone-only injectables in anorexia requires careful, informed discussion and consideration by the woman.
- Who are planning a pregnancy and are underweight:
- Should be informed that the risk of adverse pregnancy outcomes is increased when underweight and advised to delay conception until in remission. Give advice on the importance of maintaining good mental health, adequate nutrition, a healthy body weight and stopping behaviours such as binge eating, vomiting, laxatives, and excessive exercise.
- Who are pregnant need increased monitoring and support during pregnancy and postpartum.
- Eating disorders increase possible health risks to mother and child and are associated with a high risk of mental health problems in the perinatal period – seek urgent specialist advice.
- Who are sexually active should be advised of the risk of unplanned pregnancy and the need for effective contraception even if they have amenorrhoea.
- For information on what treatments may be offered in secondary care:
- Ensure the person and their family/carers have access to information and support. Be aware that:
- The family/carers of a person with an eating disorder may experience severe distress.
- The need for support (including practical support and emergency plans if the person with the eating disorder is at high medical or psychiatric risk) should be assessed.
- Some people with eating disorders may not want family/carers involved in their care, and in some cases, involvement may not be appropriate — Gillick competence should be respected in children or young people under 16 who do not want family/carers involved.
- Patient information is available from:
- Beat Eating Disorders
- NHS
- The Royal College of Psychiatrists
Basis for recommendation
The recommendations on management of a confirmed eating disorder in primary care are largely based on the National Institute of Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020] and the Faculty of Sexual and Reproductive Health (FSRH) CEU statement: contraception for women with eating disorders [CoSRH, 2021].
Ensure clear agreement between primary care and specialist care
- This recommendation is based on the NICE guideline Eating disorders: recognition and treatment which states that specialist services may include medical monitoring as part of care but in some cases the GP is responsible for this — ongoing communication and ideally a shared care agreement is needed.
- Agreements should clearly specify who is responsible for taking action if results are abnormal or deteriorating and highlight ‘concern’ and ‘alert’ ranges for clinical findings [NICE, 2020].
Monitor level of risk
The recommendations on monitoring level of risk in people with eating disorders are based on the NICE guideline Eating disorders: recognition and treatment [NICE, 2020].
- Medically unstable people with an eating disorder can appear deceptively well – changes over time which may indicate rapid decline in mental and physical health must be identified and addressed as early as possible [NICE, 2020; RCP, 2023].
Review of chronic anorexia in primary care
- The recommendations on annual review of people with chronic anorexia nervosa who are not receiving treatment in secondary care are based on the NICE guidance on eating disorders [NICE, 2020].
- Eating disorder services should provide ongoing support for people with anorexia nervosa who have declined treatment and have severe or complex problems.
Advice for those with compensatory behaviours
- Recommendations on advice for those who are vomiting, misusing laxatives or diuretics or exercising excessively is from the NICE guidance on eating disorders [NICE, 2020].
Prescribing alert
- Recommendations on prescribing in people with eating disorders are based on NICE guidance [NICE, 2020].
Management of complications and co-morbidities
- Recommendations on management of comorbidities are based on NICE guidance [NICE, 2020].
Contraception and pregnancy
The recommendations on management of women with eating disorders who require contraception, are planning a pregnancy or are pregnant are based on clinical guidance from NICE and the FSRH [NICE, 2020; CoSRH, 2021].
- The FSRH recommends LARC methods as the most effective contraceptive methods in women with eating disorders [CoSRH, 2021].
- No evidence for the effect of depot medroxyprogesterone (DMPA) on bone mineral density in women with anorexia was identified by the FSRH but as anorexia is a significant risk factor for osteoporosis they advise careful informed discussion and consideration by the woman before use.
Impact on family
- The significant impact of eating disorders on family and carers of people with eating disorders is highlighted in guidance from the Royal College of Psychiatrists and NICE [NICE, 2020; RCP, 2023].
- NICE recommends involving family and significant others in assessment and treatment of eating disorders (unless contraindicated or the person refuses) and providing the family/carers with appropriate support and information.
What specialist psychological treatments are recommended for eating disorders?
Anorexia nervosa
- For adults with anorexia nervosa, one of the following may be considered:
- Individual eating-disorder-focused cognitive behavioural therapy (CBT-ED) — typically up to 40 sessions over 40 weeks, with twice-weekly sessions in the first 2 or 3 weeks.
- Maudsley Anorexia Nervosa Treatment for Adults (MANTRA) — typically 20 sessions, with weekly sessions for the first 10 weeks and a flexible schedule after this. Up to 10 extra sessions may be added for people with complex problems.
- Specialist supportive clinical management (SSCM) — typically 20 or more weekly sessions (depending on severity).
- If individual CBT-ED, MANTRA, or SSCM is unacceptable, contraindicated or ineffective eating-disorder-focused focal psychodynamic therapy (FPT) may be considered — typically 40 sessions over 40 weeks.
- For anorexia nervosa in children and young people:
- Anorexia-nervosa-focused family therapy for children and young people (FT-AN) delivered as single-family therapy or a combination of single and multi-family therapy will be considered — typically 18–20 sessions over 1 year.
- If FT-AN is unacceptable, contraindicated or ineffective for children or young people with anorexia nervosa, individual CBT-ED or adolescent-focused psychotherapy for anorexia nervosa (AFP-AN) will be considered.
- Individual CBT-ED for children and young people with anorexia nervosa typically consists of up to 40 sessions over 40 weeks, with individual and family sessions.
- AFP-AN for children and young people typically consists of 32–40 individual sessions over 12–18 months, with 8–12 additional family sessions.
Bulimia nervosa
- Psychological treatments in adults:
- Bulimia-nervosa-focused guided self-help programmes may be considered, for example, 4 to 9 sessions lasting 20 minutes each over 16 weeks, running weekly initially.
- If bulimia-nervosa-focused guided self-help is unacceptable, contraindicated, or ineffective after 4 weeks of treatment, individual eating-disorder focused cognitive behavioural therapy (CBT-ED) may be considered. This typically consists of up to 20 sessions over 20 weeks.
- Psychological treatments in children and young people:
- Bulimia-nervosa-focused family therapy (FT-BN) may be considered in children and young people with bulimia nervosa — typically 18–20 sessions over 6 months.
- If FT-BN is unacceptable, contraindicated or ineffective, individual eating-disorder-focused cognitive behavioural therapy (CBT-ED) for children and young people with bulimia nervosa may be considered — typically 18 sessions over 6 months, with more frequent sessions early in treatment and up to 4 additional sessions with parents or carers.
Binge eating disorder
- Psychological interventions that may be offered to adults, children and young people with binge eating disorder include:
- Evidence-based self-help programmes with brief supportive sessions (for example, 9 sessions over 16 weeks).
- If guided self-help is unacceptable, contraindicated or ineffective after 4 weeks, group eating-disorder-focused cognitive behavioural therapy (CBT-ED) may be offered — typically 16 weekly 90 minute group sessions over 4 months.
- If group CBT-ED is refused or unavailable, individual CBT-ED may be considered — typically 16–20 sessions.
- Psychological treatments aimed at binge eating have a limited effect on body weight, and weight loss is not in itself a goal of therapy.
Other specified feeding and eating disorders (OSFED)
- For people with OSFED, treatments for the eating disorder it most closely resembles will be considered.
Basis for recommendation
This information on specialist psychological treatment of eating disorders is from the National Institute for Health and Care Excellence guideline Eating disorders: recognition and treatment [NICE, 2020].
Supporting evidence
This CKS topic is largely based on the Royal College of Psychiatrists clinical guideline Medical emergencies in eating disorders: guidance on recognition and management [RCP, 2023], the National Institute of Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020], the BMJ Best Practice guidelines Anorexia nervosa [BMJ Best Practice, 2023a] and Bulimia nervosa [BMJ Best Practice, 2023b], the Royal Australian and New Zealand College of Psychiatrists Clinical practice guidelines for the treatment of eating disorders [Hay, 2014], the American Academy of Child and Adolescent Psychiatry (AACAP) Practice parameter for the assessment and treatment of children and adolescents with eating disorders [Lock, 2015], and expert opinion in review articles [Campbell, 2014; Zipfel, 2015; Montano, 2016; Allison, 2017; Bould, 2017b; Bould, 2017a; Rowe, 2017; Wassenaar, 2018; Hay, 2020; Giel, 2022]. The rationale for the primary care assessment and management of Eating Disorders is discussed in the relevant basis for recommendation sections.
How this topic was developed
This section briefly describes the processes used in developing and updating this topic. Further details on the full process can be found in the About Us section and on the Clarity Informatics website.
Search strategy
Scope of search
A literature search was conducted for guidelines and systematic reviews on primary care management of eating disorders. This CKS topic is largely based on the National Institute for Health and Care Excellence (NICE) guideline Eating disorders: recognition and treatment [NICE, 2020].
Search dates
May 2019 - June 2024
Key search terms
The terms listed below are the core search terms that were used for EBSCOhost MEDLINE (searched 30th May 2019). These were combined with filters to identify guidelines, systematic reviews and primary care relevant literature in EBSCOhost MEDLINE. The strategy was adapted for The Cochrane Library databases.
S7 S1 OR S2 OR S3 OR S4 OR S5 OR S6
S6 AB osfed OR TI osfed
S5 AB ( binge eating or binge-eating or binging or bingeing ) OR TI ( binge eating or binge-eating or binging or bingeing )
S4 AB bulimia nervosa OR TI bulimia nervosa
S3 AB anorexia nervosa OR anorexia nervosa
S2 AB eating disorder* OR TI eating disorder*
S1 (MH "Feeding and Eating Disorders+")
Sources of guidelines
- National Institute for Health and Care Excellence (NICE)
- Scottish Intercollegiate Guidelines Network (SIGN)
- Royal College of Physicians
- Royal College of General Practitioners
- Royal College of Nursing
- NICE Evidence
- World Health Organization
- Guidelines International Network
- TRIP database
- Agency for Healthcare Research and Quality
- National Health and Medical Research Council (Australia)
- Royal Australian College of General Practitioners
- British Columbia Medical Association
- Canadian Medical Association
- Alberta Medical Association
- Michigan Quality Improvement Consortium
- Singapore Ministry of Health
- National Resource for Infection Control
- RefHELP NHS Lothian Referral Guidelines
- Medline (with guideline filter)
- Driver and Vehicle Licensing Agency
- NHS Health at Work (occupational health practice)
Sources of systematic reviews and meta-analyses
- The Cochrane Library:
- Systematic reviews
- Protocols
- Database of Abstracts of Reviews of Effects
- Medline (with systematic review filter)
- EMBASE (with systematic review filter)
Sources of health technology assessments and economic appraisals
- NIHR Health Technology Assessment programme
- The Cochrane Library:
- NHS Economic Evaluations
- Health Technology Assessments
- Canadian Agency for Drugs and Technologies in Health
- International Network of Agencies for Health Technology Assessment
Sources of randomized controlled trials
- The Cochrane Library:
- Central Register of Controlled Trials
- Medline (with randomized controlled trial filter)
- EMBASE (with randomized controlled trial filter)
Sources of evidence based reviews and evidence summaries
Sources of national policy
- Department of Health
- Health Management Information Consortium (HMIC)
Patient experiences
Sources of medicines information
The following sources are used by CKS pharmacists and are not necessarily searched by CKS information specialists for all topics. Some of these resources are not freely available and require subscriptions to access content.
Stakeholder engagement
Our policy
The external review process is an essential part of CKS topic development. Consultation with a wide range of stakeholders provides quality assurance of the topic in terms of:
- Clinical accuracy.
- Consistency with other providers of clinical knowledge for primary care.
- Accuracy of implementation of national guidance (in particular NICE guidelines).
- Usability.
Principles of the consultation process
- The process is inclusive and any individual may participate.
- To participate, an individual must declare whether they have any competing interests or not. If they do not declare whether or not they have competing interests, their comments will not be considered.
- Comments received after the deadline will be considered, but they may not be acted upon before the clinical topic is issued onto the website.
- Comments are accepted in any format that is convenient to the reviewer, although an electronic format is encouraged.
- External reviewers are not paid for commenting on the draft topics.
- Discussion with an individual or an organization about the CKS response to their comments is only undertaken in exceptional circumstances (at the discretion of the Clinical Editor or Editorial Steering Group).
- All reviewers are thanked and offered a letter acknowledging their contribution for the purposes of appraisal/revalidation.
- All reviewers are invited to be acknowledged on the website. All reviewers are given the opportunity to feedback about the external review process, enabling improvements to be made where appropriate.
Stakeholders
- Key stakeholders identified by the CKS team are invited to comment on draft CKS topics. Individuals and organizations can also register an interest to feedback on a specific topic, or topics in a particular clinical area, through the Getting involved section of the Clarity Informatics website.
- Stakeholders identified from the following groups are invited to review draft topics:
- Experts in the topic area.
- Professional organizations and societies (for example, Royal Colleges).
- Patient organizations, Clarity has established close links with groups such as Age UK and the Alzheimer’s Society specifically for their input into new topic development, review of current topic content and advice on relevant areas of expert knowledge.
- Guideline development groups where the topic is an implementation of a guideline.
- The British National Formulary team.
- The editorial team that develop MeReC Publications.
- Reviewers are provided with clear instructions about what to review, what comments are particularly helpful, how to submit comments, and declaring interests.
Patient engagement
Clarity Informatics has enlisted the support and involvement of patients and lay persons at all stages in the process of creating the content which include:
- Topic selection
- Scoping of topic
- Selection of clinical scenarios
- First draft internal review
- Second draft internal review
- External review
- Final draft and pre-publication
Our lay and patient involvement includes membership on the editorial steering group, contacting expert patient groups, organizations and individuals.
Evidence exclusion criteria
Our policy
Scoping a literature search, and reviewing the evidence for CKS is a methodical and systematic process that is carried out by the lead clinical author for each topic. Relevant evidence is gathered in order that the clinical author can make fully informed decisions and recommendations. It is important to note that some evidence may be excluded for a variety of reasons. These reasons may be applied across all CKS topics or may be specific to a given topic.
Studies identified during literature searches are reviewed to identify the most appropriate information to author a CKS topic, ensuring any recommendations are based on the best evidence. We use the principles of the GRADE and PICOT approaches to assess the quality of published research. We use the principles of AGREE II to assess the quality of published guidelines.
Standard exclusions for scoping literature:
- Animal studies
- Original research is not written in English
Possible exclusions for reviewed literature:
- Sample size too small or study underpowered
- Bias evident or promotional literature
- Population not relevant
- Intervention/treatment not relevant
- Outcomes not relevant
- Outcomes have no clear evidence of clinical effectiveness
- Setting not relevant
- Not relevant to UK
- Incorrect study type
- Review article
- Duplicate reference
Organizational, behavioural and financial barriers
Our policy
The CKS literature searches take into consideration the following concepts, which are discussed at the initial scoping of the topic.
- Feasibility
- Studies are selected depending on whether the intervention under investigation is available in the NHS and can be practically and safely undertaken in primary care.
- Organizational and Financial Impact Analysis
- Studies are selected and evaluated on whether the intervention under investigations may have an impact on local clinical service provision or national impact on cost for the NHS. The principles of clinical budget impact analysis are adhered to, evaluated and recorded by the author. The following factors are considered when making this assessment and analysis.
- Eligible population
- Current interventions
- Likely uptake of new intervention or recommendation
- Cost of the current or new intervention mix
- Impact on other costs
- Condition-related costs
- In-direct costs and service impacts
- Time dependencies
- Cost-effectiveness or cost-benefit analysis studies are identified where available.
We also evaluate and include evidence from NICE accredited sources which provide economic evaluations of recommendations, such as NICE guidelines. When a recommended action may not be possible because of resource constraints, this is explicitly indicated to healthcare professionals by the wording of the CKS recommendation.
Declarations of interest
Our policy
Clarity Informatics requests that all those involved in the writing and reviewing of topics, and those involved in the external review process to declare any competing interests. Signed copies are securely held by Clarity Informatics and are available on request with the permission of the individual. A copy of the declaration of interest form which participants are asked to complete annually is also available on request. A brief outline of the declarations of interest policy is described here and full details of the policy is available on the Clarity Informatics website. Declarations of interests of the authors are not routinely published, however competing interests of all those involved in the topic update or development are listed below. Competing interests include:
- Personal financial interests
- Personal family interest
- Personal non-financial interest
- Non-personal financial gain or benefit
Although particular attention is given to interests that could result in financial gains or losses for the individual, competing interests may also arise from academic competition or for political, personal, religious, and reputational reasons. An individual is not obliged to seek out knowledge of work done for, or on behalf of, the healthcare industry within the departments for which they are responsible if they would not normally expect to be informed.
Who should declare competing interests?
Any individual (or organization) involved in developing, reviewing, or commenting on clinical content, particularly the recommendations should declare competing interests. This includes the authoring team members, expert advisers, external reviewers of draft topics, individuals providing feedback on published topics, and Editorial Steering Group members. Declarations of interest are completed annually for authoring team and editorial steering group members, and are completed at the start of the topic update and development process for external stakeholders.
Competing interests declared for this topic:
None.
References
- AED (2020) About Eating Disorders. Academy for Eating Disorders. https://www.aedweb.org [Free Full-text]
- Allison, E., Dawson, N., Phillips, J., et al. (2017) Fifteen minute consultation: A structured approach to the management of children and adolescents with medically unstable anorexia nervosa. Archives of disease in childhood. Education and practice edition. 102(4), 175-181. [Free Full-text]
- APA (2022) Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). American Psychiatric Association. https://dsm.psychiatryonline.org [Free Full-text]
- Berends T, Boonstra N, van Elburg A (2018) Relapse in anorexia nervosa: a systematic review and meta-analysis. Curr Opin Psychiatry 31(6), 445-455.
- BMJ Best Practice (2023a) Anorexia nervosa. London: BMJ Publishing Group.
- BMJ Best Practice (2023b) Bulimia nervosa. London.
- Bould, H., Newbegin, C., Stewart, A., et al. (2017a) Eating disorders in children and young people. BMJ 359(j5245). [Abstract]
- Bould, H., Newbegin, C., Fazel, M., et al. (2017b) Assessment of child or young person with a possible eating disorder. BMJ 359(5328). [Abstract]
- Campbell, K. and Peebles, R. (2014) Eating disorders in children and adolescents: state of the art review. Pediatrics 134(3), 582-592. [Abstract]
- CoSRH (2021) Contraception for Women with Eating Disorders. College of Sexual and Reproductive Healthcare. https://www.cosrh.org [Free Full-text]
- Galmiche, M., Déchelotte, P., Lambert, G. and Tavolacci, M.P. (2019) Prevalence of eating disorders over the 2000-2018 period: a systematic literature review. American Journal of Clinical Nutrition 109(5), 1402-1413. [Abstract]
- Giel, K.E., Bulik, C.M., Fernandez-Aranda, F., et al. (2022) Binge eating disorder. Nature Reviews Disease Primers 8(1), 16. [Abstract]
- Harrington, B.C., Jimerson, M., Haxton, C. and Jimerson, D.C. (2015) Initial evaluation, diagnosis, and treatment of anorexia nervosa and bulimia nervosa. American Family Physician 91(1), 46-52. [Abstract]
- Hay, P., Chinn, D., Forbes, D., et al. (2014) Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of eating disorders. Australian and New Zealand journal of psychiatry 48(11), 977-1008. [Abstract]
- Hay, P. (2020) Current approach to eating disorders: a clinical update. International Medicine Journal 50(1), 24-29. [Abstract]
- Keel, P. and Brown, T. (2010) Update on course and outcome in eating disorders. International Journal of Eating Disorders 43(3), 195-204. [Abstract]
- Keski-Rahkonen, A. and Mustelin, L. (2016) Epidemiology of eating disorders in Europe: prevalence, incidence, comorbidity, course, consequences, and risk factors. Current Opinions in Psychiatry 29(6), 340-345. [Abstract]
- Kimmel, M.C., Ferguson, E.H., Zerwas, S., et al. (2016) Obstetric and gynecologic problems associated with eating disorders. International Journal of Eating Disorders 49(3), 260-275.
- Lock, J. and La Via, M.C.; American Academy of Child and Adolescent Psychiatry (AACAP) Committee on Quality Issues (CQI) (2015) Practice parameter for the assessment and treatment of children and adolescents with eating disorders. Journal of the American Academy of Child and Adolescent Psychiatry 54(5), 412-425. [Abstract]
- Mehler, P.S. and Brown, C. (2015) Anorexia nervosa - medical complications. Journal of Eating Disorders 3(11). [Abstract]
- Montano, C.B., Rasgon, N.L. and Herman, B.K. (2016) Diagnosing binge eating disorder in a primary care setting. Postgraduate Medicine 128(1), 115-123. [Abstract]
- NICE (2018) Eating disorders (Quality standard 175). National Institute for Health and Care Excellence. https://www.nice.org.uk/guidance/qs175
- NICE (2020) Eating disorders: recognition and treatment. National Institute for Health and Care Excellence. https://www.nice.org.uk [Free Full-text]
- Norris, M.L., Harrison, M.E., Isserlin, L., et al. (2016) Gastrointestinal complications associated with anorexia nervosa: A systematic review. International Journal of Eating Disorders 49(3), 216-237. [Abstract]
- RCP (2019) Position statement on early intervention for eating disorders. Royal College of Psychiatrists. [Free Full-text]
- RCP (2023) College Report CR233: Medical Emergencies in Eating Disorders: Guidance on Recognition and Management. Royal College of Psychiatrists. https://www.rcpsych.ac.uk [Free Full-text]
- Rowe, E. (2017) Early detection of eating disorders in general practice. Australian Family Physician 46(11), 833-838. [Abstract]
- Sachs, K.V., Harnke, B., Mehler, P.S. and Krantz, M.J. (2016) Cardiovascular complications of anorexia nervosa: A systematic review. International Journal of Eating Disorders 49(3), 238-48-248. [Abstract]
- Silén, Y. and Keski-Rahkonen, A. (2022) Worldwide prevalence of DSM-5 eating disorders among young people. Current Opinions in Psychiatry 35(6), 362-371. [Abstract]
- Treasure, J., Duarte, T.A. and Schmidt, U. (2020) Eating disorders. Lancet 395(10227), 899-911. [Abstract]
- van Eeden, A.E., van Hoeken, D. and Hoek, H.W. (2021) Incidence, prevalence and mortality of anorexia nervosa and bulimia nervosa. Current Opinions in Psychiatry 34(6), 515-524. [Abstract]
- Wassenaar, E., OʼMelia, A.M. and Mehler, P.S. (2018) Gynecologic Care for Adolescents and Young Women With Eating Disorders. Obstetrics & Gynecology 132(4), 1065-1066. [Abstract]
- Westmoreland, P., Krantz, M.J. and Mehler, P.S. (2016) Medical Complications of Anorexia Nervosa and Bulimia. American Journal of Medicine 129(1), 30-37.
- Zipfel, S., Giel, K.E., Bulik, C.M., et al. (2015) Anorexia nervosa: aetiology, assessment, and treatment. Lancet Psychiatry 12, 1099-1111. [Abstract]