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Domperidone is now contraindicated in people with phaeochromocytoma (a rare tumour of the adrenal gland). The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update in response to a small number of reports relating to severe episodes of hypertension in these people.  

The MHRA advises that patients with confirmed or suspected phaeochromocytoma should stop taking domperidone immediately and be switched to an alternative treatment, and if a patient taking domperidone has an episode of severe hypertension, further investigations for phaeochromocytoma should be considered. 

Pharmacists should advise people to seek medical attention immediately if they experience symptoms of severe high blood pressure. These can include, but are not limited to: persistent headache, blurred vision, shortness of breath and chest pain. 

Source: MHRA