empty

Bipolar disorder tablets to be discontinued

Priadel 200mg and 400mg modified release tablets are to be discontinued, with all remaining supplies expected to run out by April of next year. 

The product is a first-line treatment for patients with bipolar disorder, and is also licensed for the treatment and prophylaxis of recurrent depression and aggressive or self-harming behaviour. It is also used off-licence in the treatment of cluster headaches.

Manufacturer Essential Pharma said that “restrictions on permitted pricing” meant it was “no longer viable” to produce the tablets.

The MHRA issued a supply disruption alert (SDA) on Friday explaining that while other brands of lithium carbonate are available, including Camcolit and Liskonum, switching patients from Priadel will “require individualised determination of dose, close monitoring of serum lithium levels and vigilance for relapse and tolerability in all cases”.

This is because clinical guidance states that patients should be maintained on the same brand of lithium to maintain consistent serum lithium levels.

The SDA states that all patients being switched from Priadel to another lithium formulation should have tailored management plans, and that prescribers should seek to involve patients or their carers in the decision making process.

The announcement does not affect supplies of Priadel 520/5ml liquid preparation, though pharmacy teams are reminded that this contains lithium citrate rather than lithium carbonate.

“If prescribers deem a switch to a liquid formulation appropriate, relevant guidance should be consulted to ensure safe switching,” according to the SDA.  

The Royal College of Psychiatrists issued a statement on August 3 saying it was aware that Essential Pharma was planning to stop producing the tablets, an that it was working with the Department of Health and Social Care and NHS services to develop guidance for clinicians and patients.

Latest discussions

  1. Are pharmacists guinea pigs for covid19

    VIVA LA PDAU,  VIVA LA CAC After the la...

  2. Are pharmacists guinea pigs for covid19

    What do you expect? For years the Pharma...




This website is for healthcare professionals, people who work in pharmacy and pharmacy students. By clicking into any content, you confirm this describes you and that you agree to Pharmacy Magazine's Terms of Use and Privacy Policy.

We use essential, performance, functional and advertising cookies to give you a better web experience. Find out how to manage these cookies here. We also use Interest Based Advertising Cookies to display relevant advertisements on this and other websites based on your viewing behaviour. By clicking "Accept" you agree to the use of these Cookies and our Cookie Policy.