Pregnancy Sexual health Women's health
Contraception - IUC
Last revised in November 2025
Intrauterine contraceptives (IUCs) are long-acting reversible contraceptives (LARCs) which have a licensed duration of use of 310 years
Contraception - IUC: Summary
- Intrauterine contraception (IUC) methods are long-acting reversible contraceptives (LARCs) with licensed durations of use ranging between 3 and 10 years.
- There are two types of IUC available in the UK: levonorgestrel intrauterine devices (LNG-IUDs) and copper intrauterine devices (Cu-IUDs).
- All Cu-IUDs in the UK have a copper surface area of at least 300 mm2. The LNG-IUDs currently available in the UK contain 52 mg, 19.5 mg, or 13.5 mg of levonorgestrel (LNG).
- The contraceptive effectiveness of IUDs is very high and is not affected by enzyme-inducing drugs or body weight/body mass index (BMI). The overall contraceptive failure rates are approximately:
- 0.6%–0.8% in the first year of use for the Cu-IUDs.
- 0.2% for the 52 mg LNG-IUD in the first year of use.
- 0.3% for the 13.5 mg and 19.5 mg LNG-IUDs during their licensed durations of use.
- Pre-fertilization effects are the main mode of action for both LNG-IUDs and Cu-IUDs, but post-fertilization effects also contribute to their contraceptive action.
- The main mode of action of LNG-IUDs is their progestogenic effects on the endometrium and cervical mucus: the effects on cervical mucus prevent the passage of sperm into the upper reproductive tract, whilst the effect on the endometrium may inhibit implantation of the fertilized ovum.
- The main mode of action of Cu-IUDs is the inhibition of fertilization through the effect of copper on the ovum and sperm.
- Risks and adverse effects of IUCs include:
- Pain on insertion.
- Expulsion of the device.
- Unscheduled bleeding.
- Uterine perforation.
- Infection, including pelvic inflammatory disease.
- Ectopic pregnancy.
- For the LNG-IUD, hormonal adverse effects, such as acne and ovarian cysts.
- IUC should only be inserted by trained and accredited healthcare professionals.
- A full medical history should be taken to assess the woman's suitability for use of the method. The UK Medical Eligibility Criteria for Contraception Use provides evidence-based guidance on prescribing contraception safely.
- A full sexual history should be taken to assess the woman's risk of sexually transmitted infections (STIs). STI testing and/or cervical screening should be offered as appropriate.
- Detailed information on the IUD and the insertion procedure should be given to enable informed decision-making.
- A bimanual pelvic examination should be performed immediately prior to insertion to assess the position, size, shape, and mobility of the uterus.
- Pregnancy should be excluded before the IUD is inserted.
Have I got the right topic?
From age 13 years to 60 years (Female).
This CKS topic covers the use of the levonorgestrel intrauterine device (LNG-IUD) and the copper intrauterine device (Cu-IUD).
This CKS topic does not cover the IUD insertion procedure. Healthcare professionals offering IUD insertion should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information about training requirements and recertification.
This CKS topic does not cover detailed assessment of factors affecting the choice of contraceptive methods, such as comorbidities, concurrent medication, age, ethical and legal issues, and sexually transmitted infections. It also does not cover the management of women requesting emergency contraception.
There are separate CKS topics on Amenorrhoea, Contraception - assessment, Contraception - barrier methods and spermicides, Contraception - combined hormonal methods, Contraception - emergency, Contraception - natural family planning, Contraception - progestogen-only methods, Contraception - sterilization, and Menorrhagia.
The target audience for this CKS topic is healthcare professionals working within the NHS in the UK, and providing first contact or primary healthcare.
How up-to-date is this topic?
Changes
October to November 2025 — reviewed. A literature search was conducted in September 2025 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic. More detail has been added to the sections on follow-up advice, new-onset pelvic pain and uterine perforation in line with guidance from the College of Reproductive and Sexual Health. No major changes to recommendations have been made.
Previous changes
August 2024 — minor update. Length of use of LNG-IUD revised to 8 years maximum for Levosert® in line with an update to the manufacturer's summary of product characteristics.
January 2024 — minor update. Length of use of LNG-IUD revised to 8 years maximum for Mirena® in line with an update to the manufacturer's summary of product characteristics.
April 2023 — minor update. Updated in line with the Faculty of Sexual and Reproductive Healthcare (FSRH) updated guideline FSRH Intrauterine Contraception [FSRH, 2023].
- Levonorgestrel intrauterine systems (LNG-IUSs) are now referred to as levonorgestrel intrauterine devices (LNG-IUDs). The FSRH updated the terminology to align with other international organisations.
- The topic title has been changed from Contraception - IUS/IUD to Contraception - IUC.
- Several sections have been updated in line with the FSRH guideline, including the sections on contraceptive effectiveness, duration of use, and risks and adverse effects. Information on managing malpositioned devices and new-onset pelvic pain has been included in the topic.
- The list of available copper intrauterine contraception devices has been removed and a link provided to the British National Formulary (BNF) and the electronic Medicines Compendium (eMC).
- The recommendations on starting, switching, and removing IUDs have been tabulated to improve usability.
- The topic has undergone minor restructuring.
September 2022 — minor update. Recommendations on switching from the progestogen-only pill drospirenone to the LNG-IUS have been added in line with the FSRH guideline Progestogen-only pills implant.
March 2021 — minor update. The recommendations on switching from a progestogen-only implant to the levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) have been updated in line with the Faculty of Sexual and Reproductive Healthcare (FSRH) guideline Progestogen-only implant.
February 2021 — reviewed. A literature search was conducted in January 2021 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials published since the last revision of the topic.
- The topic structure has been changed.
- Recommendations have been clarified in line with the updated FSRH guideline Intrauterine contraception (April 2015, amended September 2019) [FSRH, 2019].
- The section on drug interaction of the levonorgestrel intrauterine system (LNG-IUS) with Esmya® (ulipristal acetate 5 mg) has been removed. This is because the licence for Esmya® has been suspended to protect public health while a safety review is conducted following cases of liver injury requiring transplant [MHRA, 2020].
- The Quality and Outcomes Framework (QOF) indicators listed below have been removed as they were retired in April 2019 [BMS and NHS England, 2019]:
- CON001: The contractor establishes and maintains a register of women aged 54 or under who have been prescribed any method of contraception at least once in the last year, or other clinically appropriate interval, for example, the last 5 years for an IUS.
- CON003: The percentage of women, on the register, prescribed emergency hormonal contraception one or more times in the preceding 12 months by the contractor who have received information from the contractor about long-acting reversible contraception at the time or within one month of the prescription.
July 2020 — minor update. Weight gain and decreased libido have been added as adverse effects of the levonorgestrel intrauterine device (LNG-IUS) in line with the updated manufacturer's Summary of Product Characteristics (SPC).
June 2020 — minor update. Dizziness has been added as an adverse effect of the LNG-IUS in line with updated manufacturer's SPC.
May 2019 — minor update. Depression has been added as an adverse effect of the LNG-IUS in line with the manufacturer's SPC [ABPI, 2019].
March 2019 — minor update. Kyleena® has been added as a type of LNG-IUS available in the UK [ABPI, 2019].
January 2019 — minor update. Levosert® 20 micrograms/24 hours IDS is now licenced for up to 5 years use [ABPI, 2019].
February 2017 — minor update. Recommendations on when to start a copper intrauterine device (Cu-IUD) or an LNG-IUS after pregnancy, miscarriage, or termination of pregnancy have been updated in line with the Faculty of Sexual and Reproductive Healthcare (FSRH) guideline Contraception after pregnancy [FSRH, 2017].
August to October 2016 — reviewed. A literature search was conducted in June 2016 to identify evidence-based guidelines, UK policy, systematic reviews, and key randomized controlled trials (RCTs) published since the last revision of the topic. Minor structural changes have been made.
October 2015 — minor update. The sections on advantages, disadvantages, and risks have been updated to include additional information on uterine perforation as per the Medicines and Healthcare products Regulatory Agency (MHRA) drug safety update Intrauterine contraception: uterine perforation.
August 2013 — minor update. Text added to clarify that when used for protection from endometrial hyperplasia during oestrogen replacement therapy, the LNG-IUS should be retained for no longer than 5 years after insertion (the licence states 4 years), regardless of the age of the woman at insertion.
June 2013 — minor update. The 2013 Quality and Outcomes Framework (QOF) options for local implementation have been added to this topic.
March 2013 — minor update. The telephone number for NHS Direct has been updated.
January 2013 — minor update. Change to the text to reflect updated advice from the FSRH regarding the interaction between Esmya® and hormonal contraceptives.
February to June 2012 — reviewed. A literature search was conducted in December 2011 to identify evidence-based guidelines, UK policy, systematic reviews, and key RCTs published since the last revision of the topic. No changes to clinical recommendations have been made. However, recommendations have been rewritten for clarity, and superseded references and manufacturers' SPCs have been updated accordingly.
January 2012 — minor update. Typographical errors corrected.
March 2011 — topic structure revised to ensure consistency across CKS topics — no changes to clinical recommendations have been made.
February 2010 — updated to include the revised FSRH UK Medical eligibility criteria for contraceptive use.
March 2009 — minor update. The QOF indicators for sexual health have been updated.
September 2008 — minor correction. Typographical and table heading corrections to UK medical eligibility criteria tables on CU-IUDs and LNG-IUSs.
May 2008 — update to text to reflect recommendations in the new FSRH guidance Intrauterine contraception 2007.
April to September 2007 — converted from CKS guidance to CKS topic structure. The evidence base has been reviewed in detail, and recommendations are more clearly justified and transparently linked to the supporting evidence.
January 2001 — rewritten. Validated in March 2001 and issued in June 2001. Guidance on emergency contraception is no longer included but can be found as a separate CKS topic.
December 1997 — written.
Update
New evidence
Evidence-based guidelines
No new evidence-based guidelines since 1 October 2025.
HTAs (Health Technology Assessments)
No new HTAs since 1 October 2025.
Economic appraisals
No new economic appraisals relevant to England since 1 October 2025.
Systematic reviews and meta-analyses
No new systematic reviews or meta-analysis which reach the CKS threshold for inclusion since1 October 2025.
Primary evidence
No new primary evidence which reaches the CKS threshold for inclusion published since 1 October 2025.
New policies
No new national policies or guidelines since 1 October 2025.
New safety alerts
No new safety alerts since 1 October 2025.
Changes in product availability
No changes in product availability since 1 October 2025.
Goals and outcome measures
Goals
To support primary healthcare professionals to:
- Support women to make informed decisions about choosing and using intrauterine contraception (IUC).
- Provide detailed information on the different IUCs, including information on their modes of action; contraceptive efficacy; advantages and disadvantages; and risks, adverse effects, and associated problems.
- Manage adverse effects and problems associated with IUCs.
Outcome measures
No outcome measures were found during the review of this topic.Audit criteria
No audit criteria were found during the review of this topic.QOF indicators
No QOF indicators were found during the review of this topic.
QIPP - options for local implementation
No QIPP criteria were found during the review of this topic.
NICE quality standards
Contraception
- Women asking for contraception from contraceptive services are given information about, and offered a choice of, all methods including long-acting reversible contraception.
- Women asking for emergency contraception are told that an intrauterine device is more effective than an oral method.
- Women who request an abortion discuss contraception with a healthcare practitioner and are offered a choice of all methods when they are assessed for abortion and before Women who give birth are given information about, and offered a choice of, all contraceptive methods by their midwife within 7 days of delivery.
Background information
What is intrauterine contraception?
- Intrauterine contraception (IUC) methods are long-acting reversible contraceptives (LARCs) with licensed durations of use ranging between 3 and 10 years (depending on the device used).
- A LARC is a contraceptive method that requires administration less than once per cycle or month.
- LARC methods (including IUC) are more cost-effective. They may be more convenient than shorter-acting methods (such as oral contraceptives) because typical use failure rates are significantly lower, and users need to visit contraceptive services less frequently.
What types of intrauterine contraception are available in the UK?
- There are two types of Intrauterine contraception (IUC) available in the UK: levonorgestrel intrauterine devices (LNG-IUDs) and copper intrauterine devices (Cu-IUDs).
- LNG-IUDs were formerly referred to as levonorgestrel intrauterine systems (LNG-IUSs). The College of Sexual and Reproductive Healthcare (CoSRH) has aligned the terminology with other international organizations.
- The LNG-IUD is a T-shaped device with an elastomere core containing the progestogen levonorgestrel (LNG).
- There are currently five LNG-IUDs available in the UK: Benilexa® (52 mg LNG), Levosert® (52 mg LNG), Mirena® (52 mg LNG), Kyleena® (19.5 mg LNG), and Jaydess® (13.5 mg LNG). Their licensed durations of use for contraception range between 3 and 8 years (depending on the device used).
- See the British National Formulary (BNF) or the electronic Medicines Compendium (eMC) for more information.
- There are currently five LNG-IUDs available in the UK: Benilexa® (52 mg LNG), Levosert® (52 mg LNG), Mirena® (52 mg LNG), Kyleena® (19.5 mg LNG), and Jaydess® (13.5 mg LNG). Their licensed durations of use for contraception range between 3 and 8 years (depending on the device used).
- The Cu-IUDs are non-hormonal and vary in size and shape.
- Cu-IUDs consist of copper and plastic and may contain barium for radio-opacity. Some brands contain a core of silver or other inert metal to help maintain the integrity of the wire. All Cu-IUDs in the UK have a copper surface area of 300 mm2 or more.
- There are several Cu-IUDs available in the UK, such as Copper T380 A® (380 mm2 of copper), Multiload® Cu375 (375 mm2 of copper), and GyneFix® 330 (330 mm2 of copper). Their licensed durations of use for contraception are 5 or 10 years (depending on the device used).
- See the BNF or the electronic Medicines Compendium (eMC) for more information on available Cu-IUDs.
- The CoSRH supports extended use of the Cu-IUD when inserted at age 40 years or over. A Cu-IUD containing at least 300 mm2 of copper inserted at or after the age of 40 years can be used for contraception until menopause.
- Menopause can be diagnosed 1 year after the final menstrual period if this occurs when the woman is aged 50 years or older. See the CKS topic on Menopause for more information.
- Cu-IUDs are also highly effective emergency contraception that can be retained to provide ongoing contraception.
- See the CKS topic on Contraception - emergency for more information.
How does intrauterine contraception work?
- Pre-fertilization effects are the main mode of action for both levonorgestrel intrauterine devices (LNG-IUDs) and copper intrauterine devices (Cu-IUDs), but post-fertilization effects also contribute to their contraceptive action.
- Whilst there is potential for IUDs to interfere with implantation, reduced rates of blastocyst formation have been observed in IUD users compared with non-users, suggesting that pre-fertilization effects are their main mode of action.
- The main mode of action of LNG-IUDs is their progestogenic effects on the endometrium and cervical mucus: the effects on cervical mucus prevent the passage of sperm into the upper reproductive tract, whilst the effect on the endometrium may inhibit implantation of the fertilized ovum.
- LNG-IUDs inhibit ovulation in some women. A foreign body effect may also contribute.
- Within 1 month of insertion of the LNG-IUD, high intrauterine concentrations of levonorgestrel induce endometrial atrophy, and additional alterations within the endometrium (changes in the intercellular junctions between the endometrial epithelial and stromal cells) and an increase in endometrial phagocytic cells may also contribute to the contraceptive effect.
- The LNG-IUD has little effect on the hypothalamic-pituitary-ovarian axis; serum estradiol concentrations are not reduced, and most women (over 75%) will continue to ovulate while using the LNG-IUD. The incidence of anovulation is lower with the 13.5 mg LNG-IUD than with the 52 mg LNG-IUD.
- LNG-IUDs are effective for contraception 7 days after insertion.
- The main mode of action of Cu-IUDs is the inhibition of fertilization through the effect of copper on the ovum and sperm.
- Copper in the cervical mucus also inhibits the passage of sperm into the upper reproductive tract.
- Cu-IUDs also cause an inflammatory response within the endometrium, which could impair implantation.
- Cu-IUDs are effective immediately following insertion.
How effective are intrauterine contraception?
- The contraceptive effectiveness of intrauterine contraception is high and is not affected by enzyme-inducing drugs or body weight/body mass index (BMI).
- For the levonorgestrel intrauterine device (LNG-IUD):
- The contraceptive failure rate for a 52 mg device in the first year of use has been estimated at 0.2% when used perfectly (consistently and correctly) and 0.2% when used typically.
- The contraceptive failure rate during licensed use is around 0.3% for both the 19.5 mg and 13.5 mg LNG-IUDs.
- For the copper intrauterine device (Cu-IUD):
- The contraceptive failure rate in the first year of use has been estimated at 0.6% when used perfectly (consistently and correctly) and 0.8% when used typically.
- For the levonorgestrel intrauterine device (LNG-IUD):
Advantages and disadvantages
What are the advantages and disadvantages of a levonorgestrel intrauterine device?
- Advantages of the levonorgestrel intrauterine device (LNG-IUD)
- It is safe and effective within the licensed duration.
- It can be inserted at any time in a natural menstrual cycle if it is reasonably certain that the woman is not pregnant or at risk of pregnancy. Additional contraception may be required — see Table 1 for more information.
- It provides long-term contraception — needs to be replaced every 3, 5, or 8 years, depending on the device.
- Women who have any 52 mg LNG-IUD inserted when they are 45 years or older can use the device for contraception until age 55 years, after which time contraception is no longer required.
- Normal fertility returns as soon as the device is removed.
- Sex need not be interrupted to use.
- Periods usually become lighter and shorter, and sometimes less painful. They may stop completely after the first year of use.
- It may be suitable when combined oral contraceptives (COCs) are contraindicated (such as in women with migraine or venous thromboembolism).
- The 52 mg LNG-IUD:
- Can be used to manage menorrhagia (heavy menstrual bleeding). See the CKS topic on Menorrhagia for more information.
- May reduce pain associated with primary dysmenorrhoea, endometriosis, or adenomyosis. See the CKS topics on Dysmenorrhoea and Endometriosis for more information.
- Disadvantages of the LNG-IUD
- An internal pelvic examination is needed prior to insertion, to check that it is suitable.
- A trained healthcare provider must insert and remove the device; the woman cannot do these on her own.
- It does not protect against sexually transmitted infections (STIs).
- It is effective for contraception 7 days after insertion; therefore, additional contraception (such as a condom) may be needed. See Table 1 for more information.
- Adverse effects may occur, such as pain on insertion, acne, headaches, unscheduled bleeding, perforation of the wall of the uterus, and expulsion of the device.
What are the advantages and disadvantages of the copper intrauterine device?
- Advantages of the copper intrauterine device (Cu-IUD)
- It is safe and effective within the licensed duration.
- It can be inserted at any time in a natural menstrual cycle if it is reasonably certain that the woman is not pregnant or at risk of pregnancy, unless it qualifies for use as emergency contraception. See the CKS topic on Contraception - emergency for more information.
- It is effective for contraception immediately after insertion; therefore, additional contraception is not needed.
- It provides long-term contraception — needs to be replaced every 5 or 10 years, depending on the device.
- Women who have a Cu-IUD with a copper surface area of at least 300 mm2 inserted at age 40 years or older can use the device for contraception until menopause.
- Normal fertility returns as soon as the device is removed.
- Sex need not be interrupted to use.
- There are no hormonal adverse effects.
- There are no drug interactions.
- It may be suitable when hormonal contraceptives are contraindicated (such as in women with migraine or venous thromboembolism).
- Disadvantages of the Cu-IUD
- An internal pelvic examination is needed prior to insertion, to check that it is suitable.
- A trained healthcare provider must insert and remove the device; the woman cannot do these on her own.
- It does not protect against sexually transmitted infections (STIs).
- Adverse effects may occur, such as pain on insertion, unscheduled bleeding, expulsion of the device, and perforation of the wall of the uterus.
Risks, adverse effects, and associated problems
What are the possible risks and adverse effects of a levonorgestrel intrauterine device?
- Breast cancer
- The available evidence suggests that there may be an association between current or recent hormonal contraception use, including levonorgestrel-releasing intrauterine devices (LNG-IUDs), and breast cancer; however, any potential increased risk appears to be small.
- Bone mineral density (BMD)
- Limited evidence suggests that LNG-IUD use has no significant effect on serum estradiol levels or BMD.
- Expulsion
- The overall risk of expulsion of an intrauterine contraception (IUC) device is approximately 1 in 20, and expulsion appears to be most common in the first year of use, particularly within 3 months after insertion.
- Expulsion rates are higher when inserted immediately postpartum compared with interval postpartum insertion or insertion in women who have not had a recent pregnancy.
- Expulsion rates may be higher in adolescents, those who have the IUC inserted after late first-trimester or second-trimester surgical abortions, those with fibroids and menorrhagia, those with uterine cavity distortion, those concurrently using a menstrual cup with the IUC, those who have had a previous expulsion and those with a BMI over 25.
- See the section on Malpositioned/expelled device for management information.
- Hormonal adverse effects
- Acne, breast tenderness, headache, and mood changes have been reported with the LNG-IUD. However, evidence is too limited to confirm or exclude a causative effect.
- When present, these symptoms appear to be more prevalent in the first few months after insertion but decrease with time.
- Infection
- The risk of pelvic infection appears to increase in the first 3 weeks after IUC insertion. However, the overall risk is very low (less than 1%).
- Evidence on the effect of IUC use on the risk of vulvovaginal candidiasis and/or bacterial vaginosis is limited and conflicting.
- Pelvic actinomycosis is a very rare, chronic bacterial pelvic infection that is associated with long-term IUC use.
- See the section on Infection for management information.
- Libido
- Decreased libido has been reported with IUC use. However, the evidence suggests that for most users, an IUC has either no impact or a positive impact on sexual experiences.
- If a woman reports concern about their libido, other possible contributing factors should be considered. If the woman considers that the IUC is adversely affecting her libido, an alternative contraceptive method should be considered.
- Malpositioned device
- The expected position of a T-shaped IUC would be that both horizontal arms are fully extended at the uterine fundus, parallel to the axis of the uterine cornua, with the vertical stem pointing directly downwards and centrally into the uterine cavity and not encroaching on the cervical canal.
- A malpositioned IUC may be:
- Malrotated — the IUC may be inverted (upside down), transverse or partially rotated on either the horizontal or vertical axis.
- Displaced — downward (non-fundal –within the uterine cavity but sitting lower than expected), lateral (not central in the cavity, arms may not be deployed/only partially deployed/embedded/in the fallopian tube), cervical (stem partially or fully within the cervix).
- Embedded — arm and/or stem partially or fully within the myometrium.
- Incorrectly deployed — one or both arms not fully extended.
- Correct position of an IUC at the fundus may be necessary for maximum contraceptive effectiveness, and incorrect placement may be associated with increased risk of contraceptive failure.
- The available evidence is too limited to predict failure rates of malpositioned IUCs, and there is insufficient evidence to definitively guide whether a malpositioned IUC should be left in situ or removed and replaced.
- See the section on Malpositioned/expelled device for management information.
- Non-visible threads
- The threads of the IUC may not be visible in the vagina as a result of expulsion, perforation, or pregnancy, or the device being correctly sited but with threads within the cervical canal or uterus.
- The prevalence of non-visible threads may be as high as 18% (standard IUC insertion), 30% (IUC insertion within 48 hours of vaginal birth), and 50% (IUC insertion at the time of caesarean section).
- See the section on Non-visible threads for management information.
- Ovarian cysts
- Although the incidence of ovarian cysts may be elevated during LNG-IUD use, this does not appear to be clinically significant.
- The presence of (or history of) ovarian cysts or polycystic ovary syndrome is not a contraindication to the use of intrauterine contraception (IUC).
- Pain on insertion
- Most IUC insertions are associated with mild-to-moderate pain or discomfort, but that pain can range from none to severe.
- Analgesia/anaesthetic options should be discussed and offered to all people having an IUC inserted. See the CKS topics on Analgesia - mild-to-moderate pain and NSAIDs - prescribing issues for prescribing information.
- If a requested analgesic/anaesthetic option is not available locally, refer onward to an alternative provider.
- Pelvic pain
- Pelvic pain or cramping has been reported by some women.
- New onset pelvic pain in an IUC user should be assessed, and pregnancy should be excluded.
- See the section on New-onset pelvic pain for management information.
- Pregnancy
- The risk of pregnancy (including ectopic pregnancy) is very low during the use of IUC.
- If pregnancy occurs with an IUC in situ, the likelihood of it being ectopic is greater than if pregnancy were to occur without an IUC in situ.
- A previous ectopic pregnancy is not a contraindication to IUC use.
- See the section on Pregnancy for management information.
- Unscheduled bleeding
- Altered bleeding patterns are common after LNG-IUD insertion.
- However, for all LNG-IUD types, prolonged, frequent, and irregular bleeding as well as the number of bleeding/spotting days reduce over the first year of use, and the rates of amenorrhoea and infrequent bleeding increase. By the end of the licensed duration of use, studies report amenorrhoea in 11%–12% of 13.5 mg LNG-IUD users, 23% of 19.5 mg users, and 42% of 52 mg users.
- Data are limited, but clinical experience indicates that consecutive LNG-IUD use appears to induce a small, temporary increase in bleeding/spotting in the first 90 days after the replacement device is inserted. Thereafter, bleeding/spotting returns to a very low and constant level, with higher rates of amenorrhoea than in first-time users at 4–6 weeks post insertion.
- See the section on Unscheduled bleeding for management information.
- Uterine perforation
- The rate of uterine perforation associated with IUC use is very low, with an overall risk of perforation in the general population of 1–2 in 1000.
- Postpartum interval IUC insertion (from 48 hours after childbirth) is associated with an increased risk of uterine perforation, particularly if the user is breastfeeding.
- Uterine perforation may be identified at the time of insertion or at a later date.
- Lower abdominal pain, non-visible threads, or changes in bleeding may indicate uterine perforation.
- See the section on Suspected uterine perforation for management information.
- Weight gain
- There is no evidence to support a causal association between IUC use and weight gain.
- There is no specific evidence relating to weight gain with IUC use by women with raised body mass index (BMI).
- In the general population, there are no significant differences in weight gain when LNG-IUDs are compared with copper IUDs.
What are the possible risks and adverse effects of a copper intrauterine device?
- Expulsion
- The overall risk of expulsion of an intrauterine contraception (IUC) device is approximately 1 in 20, and expulsion appears to be most common in the first year of use, particularly within 3 months after insertion.
- Expulsion rates are higher when inserted immediately postpartum compared with interval postpartum insertion or insertion in women who have not had a recent pregnancy.
- Expulsion rates may be higher in adolescents, those who have the IUC inserted after late first-trimester or second-trimester surgical abortions, those with fibroids and menorrhagia, those with uterine cavity distortion, those concurrently using a menstrual cup with the IUC, those who have had a previous expulsion and those with a BMI over 25.
- See the section on Malpositioned/expelled device for management information.
- Infection
- The risk of pelvic infection appears to increase in the first 3 weeks after IUC insertion. However, the overall risk is very low (less than 1%).
- Evidence on the effect of IUC use on risk of vulvovaginal candidiasis and/or bacterial vaginosis is limited and conflicting.
- Pelvic actinomycosis is a very rare, chronic bacterial pelvic infection that is associated with long-term IUC use.
- See the section on Infection for management information.
- Libido
- Decreased libido has been reported with IUC use. However, the evidence suggests that for most users, an IUC has either no impact or a positive impact on sexual experiences.
- If a woman reports concern about their libido, other possible contributing factors should be considered. If the woman considers that the IUC is adversely affecting her libido, an alternative contraceptive method should be considered.
- Malpositioned device
- The expected position of a T-shaped IUC would be that both horizontal arms are fully extended at the uterine fundus, parallel to the axis of the uterine cornua, with the vertical stem pointing directly downwards and centrally into the uterine cavity and not encroaching on the cervical canal.
- A malpositioned IUC may be:
- Malrotated — the IUC may be inverted (upside down), transverse or partially rotated on either the horizontal or vertical axis.
- Displaced — downward (non-fundal –within the uterine cavity but sitting lower than expected), lateral (not central in the cavity, arms may not be deployed/only partially deployed/embedded/in the fallopian tube), cervical (stem partially or fully within the cervix).
- Embedded — arm and/or stem partially or fully within the myometrium.
- Incorrectly deployed — one or both arms not fully extended.
- Correct position of an IUC at the fundus may be necessary for maximum contraceptive effectiveness and incorrect placement may be associated with increased risk of contraceptive failure.
- The available evidence is too limited to predict failure rates of malpositioned IUCs, and there is insufficient evidence to definitively guide whether a malpositioned IUC should be left in situ or removed and replaced.
- See the section on Malpositioned/expelled device for management information.
- Non-visible threads
- The threads of the IUC may not be visible in the vagina as a result of expulsion, perforation, or pregnancy, or the device being correctly sited but with threads within the cervical canal or uterus.
- The prevalence of non-visible threads may be as high as 18% (standard IUC insertion), 30% (IUC insertion within 48 hours of vaginal birth), and 50% (IUC insertion at the time of caesarean section).
- See the section on Non-visible threads for management information.
- Pain on insertion
- Most IUC insertions are associated with mild-to-moderate pain or discomfort, but that pain can range from none to severe.
- Analgesia/anaesthetic options should be discussed and offered to all people having IUC inserted. See the CKS topics on Analgesia - mild-to-moderate pain and NSAIDs - prescribing issues for prescribing information.
- If a requested analgesic/anaesthetic option is not available locally refer onward to an alternative provider.
- Pelvic pain
- Pelvic pain or cramping has been reported by some women.
- New onset pelvic pain in an IUC user should be assessed and pregnancy should be excluded.
- See the section on New-onset pelvic pain for management information.
- Pregnancy
- The risk of pregnancy (including ectopic pregnancy) is very low during use of IUC.
- If a pregnancy occurs with IUC in situ, the likelihood of it being ectopic is greater than if a pregnancy was to occur without IUC in situ.
- A previous ectopic pregnancy is not a contraindication to IUC use.
- See the section on Pregnancy for management information.
- Unscheduled bleeding
- The Cu-IUD has been associated with an increase in menstrual blood loss and intermenstrual bleeding, secondary to increased release of prostaglandin and other vasoactive agents within the endometrium as part of an inflammatory response.
- Bleeding may be heavier, longer, or more painful than prior to Cu-IUD insertion, and users may experience intermenstrual bleeding.
- Increased menstrual bleeding will often decrease over time; however, intermenstrual bleeding is less likely to do so. Studies do not suggest clinically significant decreases in haemoglobin and increased incidence of anaemia among Cu-IUD users in general.
- Bleeding patterns may differ between different Cu-IUDs; however, there is insufficient evidence to recommend one Cu-IUD device over another or predict bleeding for any specific device.
- See the section on Unscheduled bleeding for management information.
- Uterine perforation
- The rate of uterine perforation associated with IUC use is very low, with an overall risk of perforation in the general population of 1–2 in 1000.
- Postpartum interval IUC insertion (from 48 hours after childbirth) is associated with an increased risk of uterine perforation, particularly if the user is breastfeeding.
- Uterine perforation may be identified at the time of insertion or at a later date.
- Lower abdominal pain, non-visible threads or changes in bleeding may indicate uterine perforation.
- See the section on Suspected uterine perforation for management information.
- Weight gain
- There is no evidence to support a causal association between IUC use and weight gain.
- There is no specific evidence relating to weight gain with IUC use by women with raised body mass index (BMI).
- In the general population there are no significant differences in weight gain when Cu-IUDs are compared with levonorgestrel IUDs.
Where can women get intrauterine contraception?
- The levonorgestrel intrauterine device (LNG-IUD) and the copper intrauterine device (Cu-IUD) are available from:
- General practices — if staff have appropriate training in intrauterine contraception (IUC) insertion techniques.
- Contraception and sexual health clinics.
- Young person's clinics — if staff have appropriate training in IUC insertion techniques.
- Brook Advisory Centres — for people aged 25 years and younger.
Management
Scenario: Levonorgestrel intrauterine device
From age 13 years to 60 years (Female).
How should I assess a woman who is considering using the levonorgestrel intrauterine device?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification. The CoSRH Guideline Intrauterine Contraception contains detailed recommendations on criteria that should be met prior to IUC insertion.
- If the levonorgestrel intrauterine device (LNG-IUD) is being considered:
- Carry out a full medical history to assess the person's suitability for use of the LNG-IUD.
- The UK Medical Eligibility Criteria for Contraceptive Use (UKMEC) provides evidence-based guidance on prescribing contraception safely.
- Further guidance is given in the CKS topic on Contraception - assessment.
- Exclude pregnancy.
- Take a sexual history to assess the person's risk of sexually transmitted infections (STIs).
- Offer STI testing and/or cervical screening as appropriate.
- Carry out a full medical history to assess the person's suitability for use of the LNG-IUD.
- Prior to inserting the LNG-IUD:
- Provide detailed information on IUC to enable informed decision-making. This should include information on:
- Mode of action.
- Contraceptive effectiveness.
- Duration of use.
- Advantages and disadvantages.
- Potential risks, adverse effects, and associated problems, including expected changes in bleeding pattern (such as irregular bleeding and amenorrhoea).
- The IUC insertion procedure, the associated risks (including pain and uterine perforation) and analgesic/anaesthetic options.
- Perform a bimanual pelvic examination immediately prior to insertion, to assess the position, size, shape, and mobility of the uterus.
- If a woman attends to discuss IUC use in advance of the procedure, a pelvic examination is not required unless indicated by the clinical history.
- Obtain valid consent from the woman before pelvic examination and IUC insertion.
- Provide detailed information on IUC to enable informed decision-making. This should include information on:
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
Informing women about possible bleeding pattern changes
- Due to individual and cultural differences in views on bleeding patterns, infrequent bleeding or amenorrhoea may be considered a benefit by some but not all women. Informing women about possible bleeding pattern changes enables informed decision-making and improves satisfaction rates [CoSRH, 2025].
How should I start a levonorgestrel intrauterine device?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- See Table 1 for information on starting the levonorgestrel intrauterine device (LNG-IUD) in a woman who is not currently using a hormonal method of contraception.
- The following situations are considered off-label use of the LNG-IUD:
- Insertion at any time if it is reasonably certain the woman is not pregnant or at risk of pregnancy.
- Additional precautions (such as barrier methods) for at least 7 days before replacement, even if immediate replacement is intended.
- Insertion immediately following termination of pregnancy.
- Postpartum insertions within 4 weeks after delivery.
- The following situations are considered off-label use of the LNG-IUD:
Table 1: Recommendations on starting the levonorgestrel intrauterine device (no recent hormonal contraception).
| Current situation | Timing of insertion | Additional contraceptive precaution required? |
| No recent hormonal contraception and no recent pregnancy. | Any time in a natural menstrual cycle if it is reasonably certain that the woman is not pregnant or at risk of pregnancy. | Yes, for 7 days (unless inserted in the first 5† days of the menstrual cycle). |
| Cu-IUD within the licensed duration of use. | Any time if no UPSI within the last 7 days (otherwise defer until no UPSI for 7 days). | Yes, for 7 days (unless inserted in the first 5† days of the menstrual cycle). |
| Cu-IUD past the licensed duration of use. | Any time in a natural menstrual cycle if it is reasonably certain that the woman is not pregnant or at risk of pregnancy. | Yes, for 7 days (unless inserted in the first 5† days of the menstrual cycle). |
| Postpartum (vaginal birth or caesarean section, breastfeeding or not breastfeeding). | Within 48 hours after childbirth. | No. |
| From 4 weeks after childbirth if it is reasonably certain that the woman is not pregnant or at risk of pregnancy. | Yes, for 7 days (unless inserted in the first 5† days of the menstrual cycle or criteria for LAM are met). | |
| Following abortion or miscarriage. | Post-surgical abortion or surgical management of miscarriage: ideally IUC should be inserted at the time of the procedure.
| If the LNG-IUD is inserted after Day 5† post-abortion or miscarriage, additional precautions are required for 7 days. |
| Following administration of oral EC. | Should not be inserted following administration of oral EC until pregnancy can be excluded by a high-sensitivity pregnancy test taken no sooner than 3 weeks after the last UPSI. | Condoms or bridging contraception until the LNG-IUD can be inserted. |
Cu-IUD, copper intrauterine device; EC, emergency contraception; LNG-IUD, levonorgestrel intrauterine device; UPSI, unprotected sexual intercourse; LAM, lactational amenorrhea method (complete amenorrhea, fully breastfeeding, and 6 months or less postpartum) † Summary of Product Characteristics suggests this applies also to days 6 and 7 of a natural cycle. | ||
Data from: [CoSRH, 2025] | ||
How can I exclude pregnancy in a woman considering using a levonorgestrel intrauterine device?
- Health professionals can be ‘reasonably certain’ that a woman is not currently pregnant if any one or more of the following criteria are met and there are no symptoms or signs of pregnancy:
- She has not had intercourse since the start of her last normal (natural) menstrual period, since childbirth, abortion, miscarriage, ectopic pregnancy, or uterine evacuation for gestational trophoblastic disease.
- She has been correctly and consistently using a reliable method of contraception.
- For the purposes of being reasonably certain that a woman is not currently pregnant, barrier methods of contraception can be considered reliable provided they have been used consistently and correctly for every episode of intercourse.
- She is within the first 5 days of the onset of a normal (natural) menstrual period.
- She is less than 21 days postpartum (non-breastfeeding women).
- She is fully breastfeeding, amenorrhoeic, and less than 6 months postpartum.
- She is within the first 5 days after abortion, miscarriage, ectopic pregnancy, or uterine evacuation for gestational trophoblastic disease.
- She has not had intercourse for more than 21 days and has a negative high-sensitivity urine pregnancy test (able to detect human chorionic gonadotrophin [hCG] levels around 20 mIU/ml).
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025]. The information on the off-label use of the levonorgestrel intrauterine device is taken from the British National Formulary (BNF) [BNF, 2025].
How should I switch to the levonorgestrel intrauterine device from other methods of contraception?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques, or have achieved equivalent recognized competencies, and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- See Table 2 for recommendations on switching to the levonorgestrel intrauterine device (LNG-IUD) in a woman who is currently using a hormonal method of contraception.
Table 2: Recommendations on switching to the LNG-IUD from a hormonal contraceptive method.
| Switching from | Timing of insertion | Additional contraceptive precaution required? |
| CHC | Week 2 or 3 of CHC use (or subsequent weeks of continuous CHC use) or Day 1 of the HFI | No, providing CHC used correctly |
| After Day 1 of the HFI or in Week 1 of CHC use | If no UPSI since the start of the HFI: use condoms for 7 days or restart/continue CHC until used correctly for 7 days after HFI or If UPSI since the start of the HFI: restart/continue CHC use for 7 days | |
| POP-traditional | At any time if POP has been used correctly | Continue POP for 7 days or use condoms for 7 days |
| POP-desogestrel | At any time if POP has been used correctly | No |
| POP–drospirenone | During HFI (placebo pills, days 25– 28) assuming prior correct use of active pills or Days 1–7 of active pills (taken correctly) after HFI | If no UPSI since the start of the HFI – use condoms for 7 days or If UPSI since the start of the HFI – restart/continue DRSP POP until 7 consecutive active pills taken |
| Days 8–24 of active pills (taken correctly) | No | |
| ENG implant within 3 years after insertion | At any time | No |
| ENG implant in situ for 3-4 years | Any time if PT negative | Yes (7 days) Repeat PT 21 days after last UPSI |
| ENG implant in situ for longer than 4 years and no UPSI in the last 21 days | Any time if PT negative | Yes (7 days) |
| ENG implant in situ for longer than 4 years and UPSI in the last 21 days | LNG-IUD cannot be inserted until pregnancy can be excluded | Consider PT and EC Bridge with alternative contraception until pregnancy can be excluded by a high sensitivity pregnancy test taken at least 21 days after last UPSI |
Progestogen-only injectable (DMPA) 14 weeks or less post-injection | Anytime | No |
Progestogen-only injectable (DMPA) More than 14 weeks post-injection and no UPSI since 14 weeks | Anytime | Yes (7 days) |
Progestogen-only injectable (DMPA) More than 14 weeks post-injection and UPSI since 14 weeks post-injection, all of which took place at least 21 days ago | Any time if PT negative | Yes (7 days) |
Progestogen-only injectable (DMPA) More than 14 weeks post-injection and UPSI since 14 weeks post-injection, some of which took place within the last 21 days | LNG-IUD cannot be inserted until pregnancy can be excluded | Consider PT and EC Bridge with alternative contraception until pregnancy can be excluded by a high-sensitivity pregnancy test taken at least 21 days after last UPSI |
LNG-IUD 52 mg in situ for less than 8 years† or LNG-IUD 19.5 mg in situ for less than 5 years or LNG-IUD 13.5 mg in situ for less than 3 years | Any time | No Ideally abstain/use condoms for 7 days prior to change in case new device can not be inserted |
LNG-IUD 52 mg in situ for more than 8 years† and no UPSI within the last 21 days or LNG-IUD 19.5 mg in situ for more than 5 years and no UPSI within the last 21 days or LNG-IUD 13.5 mg in situ for more than 3 years and no UPSI within the last 21 days | Any time if PT negative on day of replacement | Yes (7 days) |
LNG-IUD 52 mg in situ for more than 8 years† and UPSI within the last 21 days or LNG-IUD 19.5 mg in situ for more than 5 years and UPSI within the last 21 days or LNG-IUD 13.5 mg in situ for more than 3 years and UPSI within the last 21 days | LNG-IUD cannot be inserted until pregnancy can be excluded | Consider PT and EC Bridge with alternative contraception until pregnancy can be excluded by a high-sensitivity pregnancy test taken at least 21 days after last UPSI |
CHC, combined hormonal contraception; Cu-IUD, copper intrauterine device; DMPA, depot medroxyprogesterone acetate; DRSP, drospirenone; EC, emergency contraception; ENG, etonogestrel; HFI, hormone-free interval; IUC, intrauterine contraception; LNG-IUD, levonorgestrel intrauterine device; POP, progestogen-only pill; UPSI, unprotected sexual intercourse. †Recommendations for the 52 mg LNG-IUD insertion relate to devices inserted before age 45 years. If replacing a 52 mg LNG-IUD that has been in situ for more than 8 years but was inserted after age 45 years, follow guidance for replacing a 52 mg LNG-IUD that has been in situ for less than 8 years. | ||
Data from: [CoSRH, 2025] | ||
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
How should I switch from the levonorgestrel intrauterine device to other methods of contraception?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques, or have achieved equivalent recognized competencies, and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- For information on switching from the levonorgestrel intrauterine device (LNG-IUD) to the copper IUD (Cu-IUD), see the section on Switching to a Cu-IUD.
- For information on switching from the LNG-IUD to other methods of contraception, see the CKS topics on:
What aftercare and follow-up advice should I give the woman after the insertion of the levonorgestrel intrauterine device?
After insertion of the levonorgestrel intrauterine device (LNG-IUD):
- Provide information on the specific device inserted, including:
- The name of the device.
- Mode of action.
- Duration of use.
- Time to become effective.
- Routine post-insertion check-ups are not required.
- If the device was inserted outside of the product licence, provide information on how and when a pregnancy test should be performed. See the sections on Starting an LNG-IUD and Switching to an LNG-IUD for more information.
- If the device was inserted within 48 hours of vaginal or caesarean birth, advise the woman to attend for a review within 4–6 weeks after insertion.
- Advise the woman:
- To feel for the threads of the device within the first 4–6 weeks after insertion and then at regular intervals (for example, monthly or after menses).
- That the LNG-IUD does not provide protection against sexually transmitted infections (STIs).
- Only a barrier method of contraception (such as a condom) can reduce the risk of STIs. For more information, see the CKS topic on Contraception - barrier methods and spermicides.
- To seek urgent review if she has:
- New onset pelvic pain — for more information on assessment and possible causes, see the section on new-onset pelvic pain.
- Pregnancy must be excluded.
- Symptoms of pelvic infection (for example, change in vaginal discharge, pelvic pain and intermenstrual/ postcoital bleeding).
- For more information, see the section on pelvic infection.
- A positive pregnancy test or thinks she might be pregnant.
- Symptoms suggestive of malpositioned or expelled IUC (such as change in bleeding pattern, new-onset pelvic pain or ‘lost threads’).
- If threads cannot be felt, thread length becomes shorter or longer, or the stem of the device is felt this may mean that the IUC is incorrectly sited and effectiveness cannot be guaranteed.
- Advise avoidance of sexual intercourse or use of an alternative method of contraception until the IUC position is confirmed.
- If there has been any recent unprotected intercourse, consider the need for emergency contraception. For more information, see the CKS topic on Emergency Contraception.
- If she has lower abdominal pain or discomfort and ‘lost threads’, especially with a history of pain at the time of insertion. These may indicate uterine perforation.
- Concerns regarding bleeding pattern.
- New onset pelvic pain — for more information on assessment and possible causes, see the section on new-onset pelvic pain.
- To seek medical review if:
- Menstrual abnormalities (such as unscheduled bleeding) persist beyond the initial 6 months of use.
- The device causes discomfort to her or her partner during sexual intercourse.
- She experiences any other adverse effects.
- She wants to remove the IUD (or the IUD is due for removal).
- Provide additional sources of information and advice.
- Patient information on intrauterine contraception is available online from:
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025] and the Medicines and Healthcare products Regulatory Agency (MHRA) drug safety update Intrauterine contraception: uterine perforation [MHRA, 2015].
When and how should I remove a levonorgestrel intrauterine device?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques, or have achieved equivalent recognized competencies, and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- The duration of use of a levonorgestrel intrauterine device (LNG-IUD) depends on the device used.
- See Table 3 for recommendations on the timing of LNG-IUD removal or replacement.
Table 3: Recommendations on timing of LNG-IUD removal/replacement.
| Situation | Recommendation |
| Removal — for a planned pregnancy | LNG-IUD can be removed at any time Offer appropriate pre-pregnancy advice. See the CKS topic on Antenatal care - uncomplicated pregnancy for more information. Advise that pregnancy is possible as soon as the device is removed. |
| Removal — not for planned pregnancy and not switching to an alternative | Abstain/use condoms in the 7 days prior to removal If there has been UPSI in the 7 days prior to removal, ideally defer IUD removal until no UPSI for 7 days Where this is not possible, consider EC and recommend a PT 21 days after the last episode of UPSI |
| Removal — menopause | Contraception is no longer required when a woman:
IUD should normally be removed when it is no longer required and not left in situ indefinitely. Although no longer required for contraception, an individual may continue to use a 52 mg LNG-IUD for endometrial protection as part of HRT. This should be replaced every 5 years depending on the LNG-IUD. See the CKS topic on Menopause for more information. |
| Removal and replacement | See Table 1 and Table 2 for more information. |
| Removal – switching to an alternative method of contraception | See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception. |
EC, emergency contraception; FSH, follicle-stimulating hormone; HRT, hormone replacement therapy; IUC, intrauterine contraception; LNG-IUD, levonorgestrel intrauterine device; PT, pregnancy test; UPSI, unprotected sexual intercourse. | |
Data from: [CoSRH, 2025] | |
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025]. Three LNG-IUD delivery systems Levosert®, Benilexa One Handed® and Mirena® have a license for 8 years of effective contraception, Kyleena® provides effective contraception for 5 years, and Jaydess® provides effective contraception for 3 years.
Managing adverse effects and associated problems
How should I manage infection in a woman using a levonorgestrel intrauterine device?
- If a woman with an intrauterine contraception (IUC) is diagnosed with pelvic inflammatory disease (PID), start appropriate antibiotic treatment and review after 48–72 hours. See the CKS topic on Pelvic inflammatory disease for more information.
- Consider removing the IUC if the woman wishes or if symptoms have not resolved within 48–72 hours.
- If the device is removed and the woman has had unprotected sexual intercourse within the last 7 days, consider offering emergency hormonal contraception and follow-up pregnancy testing. See the CKS topic on Contraception - emergency for more information.
- If a woman with an IUC is diagnosed with vulvovaginal candidiasis or bacterial vaginosis, see the CKS topics on Candida - female genital and Bacterial vaginosis for management information.
- If symptoms are recurrent, consider switching to an alternative method of contraception. See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
- If a woman with an IUC has actinomyces-like organisms (ALOs) on cervical cytology but is asymptomatic, there is no need to remove the device or to commence antibiotic treatment (as she is likely to be colonized rather than infected).
- If actinomycosis is suspected, further investigation and management should be discussed on an individual basis with local radiology, microbiology, and/or gynaecology teams.
How should I manage a woman with a malpositioned or expelled levonorgestrel intrauterine device?
- There is insufficient evidence to definitively guide whether a malpositioned intrauterine contraception (IUC) should be left in situ or removed and replaced.
- If suspected, management should be considered on a case-by-case basis, considering:
- The position of the IUC and the degree of malposition.
- Recent sexual history (to determine the need for pregnancy testing and/or emergency contraception [EC] and to assess the suitability of new IUC insertion). See the CKS topic on Contraception - emergency for more information on EC.
- Presence of associated symptoms (such as pain or bleeding).
- Accuracy of imaging available and certainty of the findings.
- Indication for use of the IUC.
- Type of device in situ.
- Potential consequence of complications associated with leaving the device in situ (such as expulsion or failure).
- Potential consequences of removal/replacement (such as procedure-related complications and the risk of pregnancy if unable to refit or if the user switches to a less effective method of contraception).
- The College of Sexual and Reproductive Healthcare (CoSRH) suggests that, as a general guide, any of the following findings would usually be an indication to suggest that the IUC is removed and replaced:
- IUC more than 2 cm from the fundus.
- IUC within the cervical canal (fully or partially).
- The IUC user is experiencing symptoms that may be related to malpositioning (such as pain or bleeding).
- If suspected, management should be considered on a case-by-case basis, considering:
- The overall risk of IUC expulsion is approximately 1 in 20.
- Expulsion rates are higher in certain circumstances, for example, in the first year of use (particularly within 3 months after insertion), after childbirth or abortion, in adolescents, women with fibroids, women using menstrual cups, women who have had a previous expulsion and if BMI is over 25.
- If there have been 2 or more IUC expulsions, arrange a pelvic ultrasound to assess the uterine cavity prior to the insertion of a further IUC. A post-insertion ultrasound is not predictive of the likelihood of further expulsion but can provide immediate confirmation of correct positioning.
How should I manage new-onset pelvic pain in a woman using a levonorgestrel intrauterine device?
There are many possible causes of new-onset pelvic pain in women using intrauterine contraception (IUC), many of which are not related to the IUC. A thorough clinical history and physical examination are needed to identify the differential diagnoses and guide investigation and management.
- Take a history asking about:
- The nature, onset and duration of the pain.
- Any associated symptoms, for example, change in vaginal discharge or bleeding pattern, urinary or bowel symptoms, nausea or vomiting, fever, dizziness or syncope, or pain elsewhere (such as the back or shoulder tip).
- IUC history, including time in situ, previous problems or checks, when threads were last felt or seen, changes in thread length, and any suspicion that the stem can be felt and/or seen.
- Sexual history — assess the risk of pregnancy, infection or trauma.
- Gynaecological history.
- Past medical history.
- Carry out a pregnancy test:
- Pregnancy must be excluded in all IUC users with new-onset pelvic pain.
- Where clinically indicated, perform an abdominal and pelvic examination.
- Depending on the suspected cause:
- Consider the need for further clinical assessment, such as urinalysis, STI screening, measurement of temperature/blood pressure/heart rate, pelvic ultrasound, rectal examination, and blood tests.
- If alternative causes of pelvic pain have been excluded:
- Advise the woman that the pelvic pain is likely to be caused by the IUC.
- Consider offering replacement with:
- An alternative device (for example, switching to a device with a smaller or different-shaped frame). There is insufficient evidence to suggest one device over another.
- An alternative contraceptive method. See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
Possible causes of new-onset pelvic pain
Possible causes of new-onset pelvic pain include:
- Gynaecological causes, such as:
- Malpositioned or expelled intrauterine contraception (IUC).
- Uterine perforation.
- Pregnancy (ectopic, miscarriage, or labour).
- Pelvic inflammatory disease.
- Ovarian cyst accident.
- Other causes, such as:
- Appendicitis.
- Diverticulitis.
- Irritable bowel syndrome/constipation.
- Gastrointestinal infection, obstruction, perforation, or necrosis.
- Urinary tract infection/pyelonephritis.
- Hernia.
- For more information, see the CKS topics on Abdominal pain – acute, Appendicitis, Diverticular disease, Ectopic pregnancy, Irritable bowel syndrome, Pelvic inflammatory disease, Pyelonephritis – acute and Urinary tract infection (lower) – women.
How should I manage a woman who cannot feel the threads of her levonorgestrel intrauterine device?
- If the woman cannot feel the threads of her levonorgestrel intrauterine device (LNG-IUD):
- Exclude pregnancy.
- Perform a vaginal examination. If threads are not visible on speculum examination, and uterine placement of the device cannot be confirmed clinically:
- Refer the woman for an ultrasound scan to locate the device.
- Advise her to use alternative contraception, for example, a barrier method (such as condoms) or avoid unprotected sexual intercourse (UPSI) until it is confirmed whether or not the device is correctly in place.
- Consider the need for emergency contraception. See the CKS topic on Contraception - emergency for more information.
- If the ultrasound scan confirms that the LNG-IUD is correctly located, reassure and leave the device in situ until it is due to be removed. Do not attempt to retrieve threads unless removal is required.
- As threads may remain unpalpable, advise on how and when to seek review, including if there is a change in bleeding pattern, pain or suspected expulsion.
- If ultrasonography cannot locate the device and pregnancy has been excluded, arrange further imaging (such as an abdominal and pelvic X-ray or CT scan) in line with local radiology/gynaecology protocols.
- If the device is extrauterine or if partial perforation or embedment into the uterine wall is suspected, refer to gynaecology for laparoscopic removal.
- If the device is not located on further imaging, this suggests expulsion. Offer reinsertion of a new LNG-IUD or an alternative method of contraception. See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
How should I manage a woman who becomes pregnant whilst using a levonorgestrel intrauterine device?
- If a woman is found to be pregnant whilst using the levonorgestrel intrauterine device (LNG-IUD), follow local early pregnancy assessment pathways to determine the location of the pregnancy.
- When an intrauterine pregnancy is less than 12 weeks gestation, the IUD should usually be removed, if the threads are visible, as this could improve later pregnancy outcomes.
How should I manage suspected uterine perforation in a woman using a levonorgestrel intrauterine device?
- If uterine perforation is identified at the time of insertion of the intrauterine device:
- Stop the procedure.
- Remove the device.
- Monitor vital signs (blood pressure and pulse rate) and level of discomfort until the woman is stable.
- Consider broad-spectrum antibiotics to reduce the risk of peritonitis.
- Offer alternative contraception.
- Advise the woman to seek urgent review if they develop any significant pain or any signs or symptoms of infection.
- Discuss management with gynaecology if unsure.
- If uterine perforation is suspected at any other time:
- Ensure other causes for symptoms of pelvic pain, thread problems and unscheduled bleeding (such as pregnancy) are considered. See the sections on new-onset pelvic pain, unscheduled bleeding and thread problems for more information.
- Where perforation is suspected, arrange an ultrasound scan and, if indicated, a plain abdominal and pelvic X-ray as soon as possible to locate the device.
- Advise the woman to avoid sexual intercourse or use a barrier method of contraception (such as condoms) in the interim. Consider the need for emergency contraception or pregnancy testing. See the CKS topic on Contraception - emergency for more information.
- Be aware that uterine perforation can also involve damage to the abdominal or pelvic viscera, bladder or bowel, and therefore, if perforation is confirmed, urgent liaison with gynaecology is indicated for consideration of an urgent laparoscopy in line with local protocols.
- Following confirmed or suspected uterine perforation:
- Wait at least 6 weeks before inserting subsequent intrauterine contraception.
- Referral to a specialist service, where ultrasound is available, is recommended for the subsequent insertion.
- Wait at least 6 weeks before inserting subsequent intrauterine contraception.
How should I manage unscheduled bleeding in a woman using a levonorgestrel intrauterine device?
- Exclude and/or manage situations that could result in unscheduled bleeding, such as:
- Sexually transmitted infections (STIs) — as a minimum, test for Chlamydia trachomatis. The risk of STIs is increased if the woman is under 25 years, has a new sexual partner, or has had more than one sexual partner in the last year. See the CKS topic on Chlamydia - uncomplicated genital for more information.
- Pregnancy — perform a pregnancy test.
- Malpositioned device.
- Gynaecological conditions, such as cervical and endometrial cancer — if suspected, refer the woman using a suspected cancer pathway referral (for an appointment within 2 weeks). For more information, see the CKS topic on Gynaecological cancers - recognition and referral.
- Consider performing a speculum and pelvic examination:
- For persistent bleeding beyond the first 3–6 months of use.
- For new symptoms or a change in bleeding after at least 3 months of use.
- If the woman has not participated in the NHS Cervical Screening Programme regularly. For more information, see the CKS topics on Cervical cancer and HPV and Cervical screening.
- If requested by the woman.
- If there are other symptoms, such as pelvic pain, dyspareunia, or postcoital bleeding.
- Consider performing a transvaginal ultrasound scan and/or referring for hysteroscopy if structural abnormalities (such as endometrial polyps) are suspected.
- If no other underlying cause of irregular bleeding is suspected, speculum and pelvic examinations and other investigations are normal, the bleeding can be assumed to be caused by the intrauterine device.
- Providing the woman has no other symptoms:
- Reassure her that irregular bleeding is a common adverse effect of intrauterine contraception.
- Offer tranexamic acid, a nonsteroidal anti-inflammatory drug (NSAID) or, if appropriate, a combined oral contraceptive for the management of heavy menstrual bleeding. See the CKS topic on Menorrhagia (heavy menstrual bleeding) for more information.
- If heavy bleeding remains unacceptable or if there is evidence of anaemia, consider changing to another method of contraception.
- See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
- See the CKS topic on Anaemia - iron deficiency for management information.
- Providing the woman has no other symptoms:
- Refer to gynaecology if the cause of the bleeding cannot be determined or treated in primary care.
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
Pregnancy
- The use of a levonorgestrel intrauterine device (LNG-IUD) during an existing or suspected pregnancy is contraindicated. The manufacturer of Mirena® 20 micrograms/24 hours intrauterine delivery system states that in case of an accidental pregnancy with the device in situ, the device should be removed as soon as possible due to an increased risk of abortion and preterm labour. Removal of Mirena® or probing of the uterus may also result in spontaneous abortion. Ectopic pregnancy should be excluded [EMC, 2025].
Unscheduled bleeding
- A 52mg levonorgestrel-releasing intrauterine device usually achieves a significant reduction in menstrual blood loss in 3 to 6 months of treatment. Increased menstrual flow or unexpected bleeding may be indicative of expulsion. The manufacturer of the Mirena® 20 micrograms/24 hours intrauterine delivery system recommends that if menorrhagia persists then the woman should be re-examined and the uterine cavity assessed using ultrasound scan. An endometrial biopsy should also be considered [EMC, 2025].
Scenario: Copper intrauterine device
From age 13 years to 60 years (Female).
How should I assess a woman considering using a copper intrauterine device?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification. The CoSRH Guideline Intrauterine Contraception contains detailed recommendations on criteria that should be met prior to IUC insertion.
- If the copper intrauterine device (Cu-IUD) is being considered:
- Carry out a full medical history to assess the woman's suitability for use of the Cu-IUD.
- The UK Medical Eligibility Criteria for Contraceptive Use (UKMEC) provides evidence-based guidance on prescribing contraception safely.
- Further guidance is given in the CKS topic on Contraception - assessment.
- Exclude pregnancy.
- Take a sexual history to assess the woman's risk of sexually transmitted infections (STIs).
- Offer STI testing and/or cervical screening as appropriate.
- Carry out a full medical history to assess the woman's suitability for use of the Cu-IUD.
- Prior to inserting the Cu-IUD:
- Provide detailed information on IUC to enable informed decision-making. This should include information on:
- Mode of action.
- Contraceptive effectiveness.
- Duration of use.
- Advantages and disadvantages.
- Potential risks, adverse effects, and associated problems, including expected changes in bleeding pattern (such as irregular bleeding and amenorrhoea).
- The IUC insertion procedure, the associated risks (including pain and uterine perforation) and analgesic options.
- Perform a bimanual pelvic examination immediately prior to insertion, to assess the position, size, shape, and mobility of the uterus.
- If a woman attends to discuss IUC use in advance of the procedure, a pelvic examination is not required unless indicated by the clinical history.
- Obtain valid consent from the woman before pelvic examination and IUC insertion.
- Provide detailed information on IUC to enable informed decision-making. This should include information on:
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
Informing women about possible bleeding pattern changes
- Due to individual and cultural differences in views on bleeding patterns, infrequent bleeding or amenorrhoea may be considered a benefit by some but not all women. Informing women about possible bleeding pattern changes enables informed decision-making and improves satisfaction rates [CoSRH, 2025].
How should I start a copper intrauterine device?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- See Table 4 for recommendations on starting the copper intrauterine device (Cu-IUD) in a woman who is not currently using a hormonal method of contraception.
Table 4: Recommendations on starting the copper intrauterine device (no recent hormonal contraception).
| Current situation | Timing of insertion | Additional contraceptive precaution required? |
| No recent hormonal contraception and no recent pregnancy | Any time in a natural menstrual cycle if it is reasonably certain that the woman is not pregnant or at risk of pregnancy (unless it qualifies for use as EC) | No |
| Cu-IUD within the licensed duration of use | Any time | Ideally, abstain/use condoms for 7 days prior to change in case a new device can not be inserted, unless the criteria for EC insertion are met |
| Cu-IUD past the licensed duration of use | Any time in a natural menstrual cycle if it is reasonably certain that the woman is not pregnant or at risk of pregnancy (unless it qualifies for use as EC) | No |
| Postpartum (vaginal birth or caesarean section, breastfeeding or not breastfeeding) | Within 48 hours after childbirth or from 4 weeks after childbirth if it is reasonably certain that the woman is not pregnant or at risk of pregnancy (unless criteria for use as EC apply) | No |
| Following abortion or miscarriage | Post-surgical abortion or surgical management of miscarriage: ideally IUC should be inserted at the time of the procedure Post-medical abortion or miscarriage: IUC can be inserted any time after expulsion of pregnancy | No |
| Following administration of oral EC | Within the first 5 days (120 hours) following first UPSI in a natural menstrual cycle or within 5 days after the earliest estimated day of ovulation | No additional precautions required |
| If there has been UPSI in this natural menstrual cycle that occurred more than 5 days ago and it is more than 5 days after the earliest estimated date of ovulation (or date of ovulation cannot be estimated), a Cu-IUD cannot be inserted until pregnancy can be excluded by a high-sensitivity pregnancy test taken no sooner than 3 weeks after the last episode of UPSI | Condoms or bridging contraception until Cu-IUD can be inserted | |
Cu-IUD, copper intrauterine device; EC, emergency contraception; Cu-IUD, copper intrauterine device; UPSI, unprotected sexual intercourse; IUC, intrauterine contraception
| ||
Data from: [CoSRH, 2025] | ||
How can I exclude pregnancy in a woman considering using a copper intrauterine device?
- Health professionals can be ‘reasonably certain’ that a woman is not currently pregnant if any one or more of the following criteria are met and there are no symptoms or signs of pregnancy:
- She has not had intercourse since the start of her last normal (natural) menstrual period, since childbirth, abortion, miscarriage, ectopic pregnancy, or uterine evacuation for gestational trophoblastic disease.
- She has been correctly and consistently using a reliable method of contraception.
- For the purposes of being reasonably certain that a woman is not currently pregnant, barrier methods of contraception can be considered reliable provided they have been used consistently and correctly for every episode of intercourse.
- She is within the first 5 days of the onset of a normal (natural) menstrual period.
- She is less than 21 days postpartum (non-breastfeeding women).
- She is fully breastfeeding, amenorrhoeic, and less than 6 months postpartum.
- She is within the first 5 days after abortion, miscarriage, ectopic pregnancy, or uterine evacuation for gestational trophoblastic disease.
- She has not had intercourse for more than 21 days and has a negative high-sensitivity urine pregnancy test (able to detect human chorionic gonadotrophin [hCG] levels around 20 mIU/ml).
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
- The copper intrauterine device (Cu-IUD) can be inserted within 5 days (120 hours) after the first unprotected sexual intercourse (UPSI) in a cycle [CoSRH, 2023; CoSRH, 2025].
- According to the CoSRH guideline on Emergency contraception [CoSRH, 2023].
- The earliest implantation is believed to occur 6 days after ovulation (and over 80% of implantations occur 8–10 days after ovulation). Therefore, a Cu-IUD can also be inserted up to 5 days after ovulation (for example, until day 19 of a regular, 28-day cycle). Ovulation occurs about 14 days before the onset of menstruation.
- It is established practice that the earliest likely ovulation date is estimated as the date of the start of the last menstrual period (LMP) plus the number of days in the shortest cycle minus 14.
- In order to make the estimation, the LMP must be accurately known, and the woman's cycles must be regular.
How should I switch to the copper intrauterine device from other methods of contraception?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- See Table 5 for recommendations on switching to the copper intrauterine device (CU-IUD) in a woman who is currently using a hormonal method of contraception.
Table 5: Recommendations on switching to the CU-IUD from a hormonal contraceptive method.
| Switching from | Timing of insertion | Additional contraceptive precaution required? |
| CHC | At any time, if CHC has been used correctly (or criteria for use as EC are met) | No |
| POP-traditional | At any time, if POP has been used correctly (or criteria for use as EC are met) | No |
| POP-desogestrel | At any time, if POP has been used correctly (or criteria for use as EC are met) | No |
| POP – drospirenone | At any time, if POP has been used correctly (or criteria for use as EC are met) | No |
| ENG implant within 3 years after insertion | Anytime | No |
| ENG implant in situ for 3-4 years | Any time if PT negative | No Repeat PT 21 days after last UPSI |
| ENG implant in situ for longer than 4 years and no UPSI in the last 21 days | Any time, if PT negative | No |
| ENG implant in situ for longer than 4 years and UPSI in the last 21 days | If PT is negative and all UPSI that has taken place in the last 21 days was within the last 5 days, Cu-IUD can be inserted as EC | No |
| Cu-IUD cannot be inserted if any UPSI occurred between 5 and 21 days ago | Consider PT and EC Bridge with alternative contraception until pregnancy can be excluded by a high-sensitivity PT taken no sooner than 3 weeks after the last episode of UPSI | |
Progestogen-only injectable (DMPA) 14 weeks or less post-injection | Anytime | No |
Progestogen-only injectable (DMPA) More than 14 weeks post-injection and no UPSI since 14 weeks | Anytime | No |
Progestogen-only injectable (DMPA) More than 14 weeks post-injection and UPSI since 14 weeks post-injection, all of which took place at least 21 days ago | Any time, if PT negative | No |
Progestogen-only injectable (DMPA) More than 14 weeks post-injection and UPSI since 14 weeks post-injection, some of which took place within the last 21 days | If PT negative and all UPSI that has taken place in the last 21 days was within the last 5 days, Cu-IUD can be inserted as EC | No |
| Cu-IUD cannot be inserted if any UPSI occurred between 5 and 21 days ago | Consider PT and EC Bridge with alternative contraception until pregnancy can be excluded by a high-sensitivity PT taken no sooner than 3 weeks after the last episode of UPSI | |
LNG-IUD 52 mg in situ for less than 8 years† or LNG-IUD 19.5 mg in situ for less than 5 years or LNG-IUD 13.5 mg in situ for less than 3 years | Anytime | No Ideally, abstain/use condoms for 7 days prior to change in case new device can not be inserted |
LNG-IUD 52 mg in situ for more than 8 years† and no UPSI within the last 21 days or LNG-IUD 19.5 mg in situ for more than 5 years and no UPSI within the last 21 days or LNG-IUD 13.5 mg in situ for more than 3 years and no UPSI within the last 21 days | Any time, if PT negative on day of replacement | No |
LNG-IUD 52 mg in situ for more than 8 years† and UPSI within the last 21 days or LNG-IUD 19.5 mg in situ for more than 5 years and UPSI within the last 21 days or LNG-IUD 13.5 mg in situ for more than 3 years and UPSI within the last 21 days | If PT negative and all UPSI that has taken place in the last 21 days was within the last 5 days, Cu-IUD can be inserted as EC | No |
CHC, combined hormonal contraception; Cu-IUD, copper intrauterine device; DMPA, depot medroxyprogesterone acetate; DRSP, drospirenone; EC, emergency contraception; ENG, etonogestrel; HFI, hormone-free interval; IUC, intrauterine contraception; LNG-IUD, levonorgestrel intrauterine device; POP, progestogen-only pill; PT, pregnancy test; UPSI, unprotected sexual intercourse. †Recommendations for the 52 mg LNG-IUD insertion relate to devices inserted before age 45 years. If replacing a 52 mg LNG-IUD that has been in situ for >6 years but was inserted after age 45 years, follow guidance for replacing a 52 mg LNG-IUD that has been in situ for <6 years. | ||
Data from: [CoSRH, 2025] | ||
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
How should I switch from a copper intrauterine device to other methods of contraception?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- For information on switching from the copper intrauterine device (Cu-IUD) to the levonorgestrel IUD (LNG-IUD), see the section on Switching to an LNG-IUD.
- For information on switching from the Cu-IUD to other methods of contraception, see the CKS topics on:
What aftercare and follow-up advice should I give the woman after the insertion of the copper intrauterine device?
After insertion of the copper intrauterine device (Cu-IUD):
- Provide information on the specific device inserted, including:
- The name of the device.
- Mode of action.
- Duration of use.
- Time to become effective.
- Routine post-insertion check-ups are not required.
- If the device was inserted outside of the product licence or as emergency contraception, provide information on how and when a pregnancy test should be performed. See the sections on Starting a Cu-IUD and Switching to a Cu-IUD for more information.
- If the device was inserted within 48 hours of vaginal or caesarean birth, advise the woman to attend for a review within 4–6 weeks after insertion.
- Advise the woman:
- To feel for the threads of the device within the first 4–6 weeks after insertion and then at regular intervals (for example, monthly or after menses).
- That the Cu-IUD does not provide protection against sexually transmitted infections (STIs).
- Only a barrier method of contraception (such as a condom) can reduce the risk of STIs. For more information, see the CKS topic on Contraception - barrier methods and spermicides.
- To seek urgent review if she has:
- New onset pelvic pain — for more information on assessment and possible causes, see the section on new-onset pelvic pain.
- Pregnancy must be excluded.
- Symptoms of pelvic infection (for example, change in vaginal discharge, pelvic pain and intermenstrual/ postcoital bleeding).
- For more information, see the section on pelvic infection.
- A positive pregnancy test or thinks she might be pregnant.
- Symptoms suggestive of malpositioned or expelled IUC (such as change in bleeding pattern, new-onset pelvic pain or ‘lost threads’).
- If threads cannot be felt, thread length becomes shorter or longer, or the stem of the device is felt this may mean that the IUC is incorrectly sited and effectiveness cannot be guaranteed.
- Advise avoidance of sexual intercourse or use of an alternative method of contraception until the IUC position is confirmed.
- If there has been any recent unprotected intercourse, consider the need for emergency contraception. For more information, see the CKS topic on Contraception - emergency.
- If she has lower abdominal pain or discomfort and ‘lost threads’, especially with a history of pain at the time of insertion. These may indicate uterine perforation.
- Concerns regarding bleeding pattern.
- New onset pelvic pain — for more information on assessment and possible causes, see the section on new-onset pelvic pain.
- To seek medical review if:
- Menstrual abnormalities (such as unscheduled bleeding) persist beyond the initial 6 months of use.
- The device causes discomfort to her or her partner during sexual intercourse.
- She experiences any other adverse effects.
- She wants to remove the IUD (or the IUD is due for removal).
- Provide additional sources of information and advice.
- Patient information on intrauterine contraception is available online from:
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025] and the Medicines and Healthcare products Regulatory Agency (MHRA) drug safety update Intrauterine contraception: uterine perforation [MHRA, 2015].
When and how should I remove a copper intrauterine device?
Healthcare professionals offering intrauterine contraception (IUC) should hold the appropriate College of Sexual and Reproductive Healthcare (CoSRH) Letter of Competence in Intrauterine Techniques or have achieved equivalent recognized competencies and show evidence of recertification/reaccreditation. The CoSRH website contains information on training requirements and recertification.
- The duration of use of a copper intrauterine device (Cu-IUD) depends on the device used.
- See Table 6 for recommendations on the timing of Cu-IUD removal or replacement.
Table 6: Recommendations on the timing of Cu-IUD removal or replacement.
| Situation | Recommendation |
| Removal — for a planned pregnancy | The Cu-IUD can be removed at any time Offer appropriate pre-pregnancy advice. See the CKS topic on Antenatal care - uncomplicated pregnancy for more information. Advise that pregnancy is possible as soon as the device is removed. |
| Removal — not for planned pregnancy and not switching to an alternative | Abstain/use condoms in the 7 days prior to removal If there has been UPSI in the 7 days prior to removal, ideally defer IUD removal until no UPSI for 7 days Where this is not possible, consider EC and recommend a PT 21 days after the last episode of UPSI |
| Removal — menopause | Contraception is no longer required when a woman:
IUD should normally be removed when it is no longer required and not left in situ indefinitely. |
| Removal and replacement | See Table 4 and Table 5 for more information. |
| Removal – switching to an alternative method of contraception | See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception. |
Cu-IUD, copper intrauterine device; EC, emergency contraception; FSH, follicle-stimulating hormone; HRT, hormone replacement therapy; IUC, intrauterine contraception; LMP, last menstrual period; LNG-IUD, levonorgestrel intrauterine device; UPSI, unprotected sexual intercourse. | |
Data from: [CoSRH, 2025] | |
Basis for recommendation
These recommendations are largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
Managing adverse effects and associated problems
How should I manage infection in a woman using a copper intrauterine device?
- If a woman with an intrauterine contraception (IUC) is diagnosed with pelvic inflammatory disease (PID), start appropriate antibiotic treatment and review after 48–72 hours. See the CKS topic on Pelvic inflammatory disease for more information.
- Consider removing the IUC if the woman wishes or if symptoms have not resolved within 48–72 hours.
- If the device is removed and the woman has had unprotected sexual intercourse within the last 7 days, consider offering emergency hormonal contraception and follow-up pregnancy testing. See the CKS topic on Contraception - emergency for more information.
- If a woman with an IUC is diagnosed with vulvovaginal candidiasis or bacterial vaginosis, see the CKS topics on Candida - female genital and Bacterial vaginosis for management information.
- If symptoms are recurrent, consider switching to an alternative method of contraception. See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
- If a woman with an IUC has actinomyces-like organisms (ALOs) on cervical cytology but is asymptomatic, there is no need to remove the device or to commence antibiotic treatment (as she is likely to be colonized rather than infected).
- If actinomycosis is suspected, further investigation and management should be discussed on an individual basis with local radiology, microbiology, and/or gynaecology teams.
How should I manage a woman with a malpositioned or expelled copper intrauterine device?
- There is insufficient evidence to definitively guide whether a malpositioned intrauterine contraception (IUC) should be left in situ or removed and replaced.
- If suspected, management should be considered on a case-by-case basis, considering:
- The position of the IUC and the degree of malposition.
- Recent sexual history (to determine the need for pregnancy testing and/or emergency contraception [EC] and to assess the suitability of new IUC insertion). See the CKS topic on Contraception - emergency for more information on EC.
- Presence of associated symptoms (such as pain or bleeding).
- Accuracy of imaging available and certainty of the findings.
- Indication for use of the IUC.
- Type of device in situ.
- Potential consequence of complications associated with leaving the device in situ (such as expulsion or failure).
- Potential consequences of removal/replacement (such as procedure-related complications and the risk of pregnancy if unable to refit or if the user switches to a less effective method of contraception).
- The College of Sexual and Reproductive Healthcare (CoSRH) suggests that, as a general guide, any of the following findings would usually be an indication to suggest that the IUC is removed and replaced:
- IUC more than 2 cm from the fundus.
- IUC within the cervical canal (fully or partially).
- The IUC user is experiencing symptoms that may be related to malpositioning (such as pain or bleeding).
- If suspected, management should be considered on a case-by-case basis, considering:
- The overall risk of IUC expulsion is approximately 1 in 20.
- Expulsion rates are higher in certain circumstances, for example, in the first year of use (particularly within 3 months after insertion), after childbirth or abortion, in adolescents, women with fibroids, women using menstrual cups, women who have had a previous expulsion and if BMI is over 25.
- If there have been 2 or more IUC expulsions, arrange a pelvic ultrasound to assess the uterine cavity prior to the insertion of a further IUC. A post-insertion ultrasound is not predictive of the likelihood of further expulsion but can provide immediate confirmation of correct positioning.
How should I manage new-onset pelvic pain in a woman using a copper intrauterine device?
There are many possible causes of new-onset pelvic pain in women using intrauterine contraception (IUC), many of which are not related to the IUC. A thorough clinical history and physical examination are needed to identify the differential diagnoses and guide investigation and management.
- Take a history asking about:
- The nature, onset and duration of the pain.
- Any associated symptoms, for example, change in vaginal discharge or bleeding pattern, urinary or bowel symptoms, nausea or vomiting, fever, dizziness or syncope, or pain elsewhere (such as the back or shoulder tip).
- IUC history, including time in situ, previous problems or checks, when threads were last felt or seen, changes in thread length, and any suspicion that the stem can be felt and/or seen.
- Sexual history — assess the risk of pregnancy, infection or trauma.
- Gynaecological history.
- Past medical history.
- Carry out a pregnancy test:
- Pregnancy must be excluded in all IUC users with new-onset pelvic pain.
- Where clinically indicated, perform an abdominal and pelvic examination.
- Depending on the suspected cause:
- Consider the need for further clinical assessment, such as urinalysis, STI screening, measurement of temperature/blood pressure/heart rate, pelvic ultrasound, rectal examination, and blood tests.
- If alternative causes of pelvic pain have been excluded:
- Advise the woman that the pelvic pain is likely to be caused by the IUC.
- Consider offering replacement with:
- An alternative device (for example, switching to a device with a smaller or different-shaped frame). There is insufficient evidence to suggest one device over another.
- An alternative contraceptive method. See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
Possible causes of new-onset pelvic pain
Possible causes of new-onset pelvic pain include:
- Gynaecological causes, such as:
- Malpositioned or expelled intrauterine contraception (IUC).
- Uterine perforation.
- Pregnancy (ectopic, miscarriage, or labour).
- Pelvic inflammatory disease.
- Ovarian cyst accident.
- Other causes, such as:
- Appendicitis.
- Diverticulitis.
- Irritable bowel syndrome/constipation.
- Gastrointestinal infection, obstruction, perforation, or necrosis.
- Urinary tract infection/pyelonephritis.
- Hernia.
- For more information, see the CKS topics on Abdominal pain – acute, Appendicitis, Diverticular disease, Ectopic pregnancy, Irritable bowel syndrome, Pelvic inflammatory disease, Pyelonephritis – acute and Urinary tract infection (lower) – women.
How should I manage a woman who cannot feel the threads of her copper intrauterine device?
- If the woman cannot feel the threads of her copper intrauterine device (Cu-IUD):
- Exclude pregnancy.
- Perform a vaginal examination. If threads are not visible on speculum examination, and uterine placement of the device cannot be confirmed clinically:
- Refer the woman for an ultrasound scan to locate the device.
- Advise her to use alternative contraception, for example, a barrier method (such as condoms) or avoid unprotected sexual intercourse (UPSI) until it is confirmed whether or not the device is correctly in place.
- Consider the need for emergency contraception. See the CKS topic on Contraception - emergency for more information.
- If the ultrasound scan confirms that the Cu-IUD is correctly located, reassure and leave the device in situ until it is due to be removed. Do not attempt to retrieve threads unless removal is required.
- As threads may remain unpalpable, advise on how and when to seek review, including if there is a change in bleeding pattern, pain or suspected expulsion.
- If ultrasonography cannot locate the device and pregnancy has been excluded, arrange further imaging (such as an abdominal and pelvic X-ray or CT scan) in line with local radiology protocols.
- If the device is extrauterine or if partial perforation or embedment into the uterine wall is suspected, refer to gynaecology for laparoscopic removal.
- If the device is not located on further imaging, this suggests expulsion. Offer reinsertion of a new Cu-IUD or an alternative method of contraception. See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
How should I manage a woman who becomes pregnant whilst using a copper intrauterine device?
- If a woman is found to be pregnant whilst using the copper intrauterine device (Cu-IUD), follow local early pregnancy assessment pathways to determine the location of the pregnancy.
- When an intrauterine pregnancy is less than 12 weeks gestation, the IUD should usually be removed if the threads are visible, as this could improve later pregnancy outcomes.
How should I manage suspected uterine perforation in a woman using a copper intrauterine device?
- If uterine perforation is identified at the time of insertion of the intrauterine device:
- Stop the procedure.
- Remove the device.
- Monitor vital signs (blood pressure and pulse rate) and level of discomfort until the woman is stable.
- Consider broad-spectrum antibiotics to reduce the risk of peritonitis.
- Offer alternative contraception.
- Advise the woman to seek urgent review if they develop any significant pain or any signs or symptoms of infection.
- Discuss management with gynaecology if unsure.
- If uterine perforation is suspected at any other time:
- Ensure other causes for symptoms of pelvic pain, thread problems and unscheduled bleeding (such as pregnancy) are considered.
- See the sections on new-onset pelvic pain, unscheduled bleeding and thread problems for more information.
- Where perforation is suspected, arrange an ultrasound scan and, if indicated, a plain abdominal and pelvic X-ray as soon as possible to locate the device.
- Advise the woman to avoid sexual intercourse or use a barrier method of contraception (such as condoms) in the interim. Consider the need for emergency contraception or pregnancy testing. See the CKS topic on Contraception - emergency for more information.
- Be aware that uterine perforation can also involve damage to the abdominal or pelvic viscera, bladder or bowel, and therefore, if perforation is confirmed, urgent liaison with gynaecology is indicated for consideration of an urgent laparoscopy in line with local protocols.
- Ensure other causes for symptoms of pelvic pain, thread problems and unscheduled bleeding (such as pregnancy) are considered.
- Following confirmed or suspected uterine perforation:
- Wait at least 6 weeks before inserting subsequent intrauterine contraception.
- Referral to a specialist service, where ultrasound is available, is recommended for the subsequent insertion.
- Wait at least 6 weeks before inserting subsequent intrauterine contraception.
How should I manage unscheduled bleeding in a woman using a copper intrauterine device?
- Exclude and/or manage situations that could result in unscheduled bleeding, such as:
- Sexually transmitted infections (STIs) — as a minimum, test for Chlamydia trachomatis. The risk of STIs is increased if the woman is under 25 years, has a new sexual partner, or has had more than one sexual partner in the last year. See the CKS topic on Chlamydia - uncomplicated genital for more information.
- Pregnancy — perform a pregnancy test.
- Malpositioned device.
- Gynaecological conditions, such as cervical and endometrial cancer — if suspected, refer the woman using a suspected cancer pathway referral (for an appointment within 2 weeks). For more information, see the CKS topic on Gynaecological cancers - recognition and referral.
- Consider performing a speculum and pelvic examination:
- For persistent bleeding beyond the first 3–6 months of use.
- For new symptoms or a change in bleeding after at least 3 months of use.
- If the woman has not participated in the NHS Cervical Screening Programme regularly. For more information, see the CKS topics on Cervical cancer and HPV and Cervical screening.
- If requested by the woman.
- If there are other symptoms, such as pelvic pain, dyspareunia, or postcoital bleeding.
- Consider performing a transvaginal ultrasound scan and/or referring for hysteroscopy if structural abnormalities (such as endometrial polyps) are suspected.
- If no other underlying cause of irregular bleeding is suspected, speculum and pelvic examinations and other investigations are normal, the bleeding can be assumed to be caused by the intrauterine device.
- Providing the woman has no other symptoms:
- Reassure her that irregular bleeding is a common adverse effect of intrauterine contraception.
- Cu-IUD use is associated with an increase in menstrual blood loss and intermenstrual bleeding compared with natural menstrual cycles in individuals without Cu-IUD.
- Increased menstrual bleeding associated with Cu-IUD use will often decrease over time.
- Offer tranexamic acid, a nonsteroidal anti-inflammatory drug (NSAID) or, if appropriate, a combined oral contraceptive for the management of heavy menstrual bleeding. See the CKS topic on Menorrhagia (heavy menstrual bleeding) for more information.
- Reassure her that irregular bleeding is a common adverse effect of intrauterine contraception.
- If heavy bleeding remains unacceptable or if there is evidence of anaemia, consider changing to another method of contraception.
- See the CKS topic on Contraception - assessment for information on assessing women for the different methods of contraception.
- See the CKS topic on Anaemia - iron deficiency for management information.
- Providing the woman has no other symptoms:
- Refer to gynaecology if the cause of the bleeding cannot be determined or treated in primary care.
Basis for recommendation
These recommendations are based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guidelines Intrauterine Contraception [CoSRH, 2025] and Problematic Bleeding with Hormonal Contraception [CoSRH, 2015].
Supporting evidence
This CKS topic is largely based on the College of Sexual and Reproductive Healthcare (CoSRH) clinical guideline Intrauterine Contraception [CoSRH, 2025].
- The CoSRH recommendations are based on the available evidence and on the consensus opinion of experts and the guideline development group. See the CoSRH guideline for more information.
How this topic was developed
This section briefly describes the processes used in developing and updating this topic. Further details on the full process can be found in the About Us section and on the Clarity Informatics website.
Search strategy
Scope of search
A literature search was conducted for guidelines, systematic reviews and randomized controlled trials on primary care management of contraception - IUS/IUD.
Search dates
January 2021 - September 2025
Key search terms
Various combinations of searches were carried out. The terms listed below are the core search terms that were used for Medline.
- exp contraception/
- intrauterine Devices/
- intrauterine Devices, Copper/
- Long acting reversible contraception/
- Levonorgestrel/
- LNG-IUD.kw
- Cu-IUD.kw
- LARC.ti,ab.
- intrauterine device$.kw
- levonorgestrel.kw
Sources of guidelines
- National Institute for Health and Care Excellence (NICE)
- Scottish Intercollegiate Guidelines Network (SIGN)
- Royal College of Physicians
- Royal College of General Practitioners
- Royal College of Nursing
- NICE Evidence
- World Health Organization
- Guidelines International Network
- TRIP database
- Agency for Healthcare Research and Quality
- National Health and Medical Research Council (Australia)
- Royal Australian College of General Practitioners
- British Columbia Medical Association
- Canadian Medical Association
- Alberta Medical Association
- Michigan Quality Improvement Consortium
- Singapore Ministry of Health
- National Resource for Infection Control
- RefHELP NHS Lothian Referral Guidelines
- Medline (with guideline filter)
- Driver and Vehicle Licensing Agency
- NHS Health at Work (occupational health practice)
Sources of systematic reviews and meta-analyses
- The Cochrane Library:
- Systematic reviews
- Protocols
- Database of Abstracts of Reviews of Effects
- Medline (with systematic review filter)
- EMBASE (with systematic review filter)
Sources of health technology assessments and economic appraisals
- NIHR Health Technology Assessment programme
- The Cochrane Library:
- NHS Economic Evaluations
- Health Technology Assessments
- Canadian Agency for Drugs and Technologies in Health
- International Network of Agencies for Health Technology Assessment
Sources of randomized controlled trials
- The Cochrane Library:
- Central Register of Controlled Trials
- Medline (with randomized controlled trial filter)
- EMBASE (with randomized controlled trial filter)
Sources of evidence based reviews and evidence summaries
Sources of national policy
- Department of Health
- Health Management Information Consortium (HMIC)
Patient experiences
Sources of medicines information
The following sources are used by CKS pharmacists and are not necessarily searched by CKS information specialists for all topics. Some of these resources are not freely available and require subscriptions to access content.
Stakeholder engagement
Our policy
The external review process is an essential part of CKS topic development. Consultation with a wide range of stakeholders provides quality assurance of the topic in terms of:
- Clinical accuracy.
- Consistency with other providers of clinical knowledge for primary care.
- Accuracy of implementation of national guidance (in particular NICE guidelines).
- Usability.
Principles of the consultation process
- The process is inclusive and any individual may participate.
- To participate, an individual must declare whether they have any competing interests or not. If they do not declare whether or not they have competing interests, their comments will not be considered.
- Comments received after the deadline will be considered, but they may not be acted upon before the clinical topic is issued onto the website.
- Comments are accepted in any format that is convenient to the reviewer, although an electronic format is encouraged.
- External reviewers are not paid for commenting on the draft topics.
- Discussion with an individual or an organization about the CKS response to their comments is only undertaken in exceptional circumstances (at the discretion of the Clinical Editor or Editorial Steering Group).
- All reviewers are thanked and offered a letter acknowledging their contribution for the purposes of appraisal/revalidation.
- All reviewers are invited to be acknowledged on the website. All reviewers are given the opportunity to feedback about the external review process, enabling improvements to be made where appropriate.
Stakeholders
- Key stakeholders identified by the CKS team are invited to comment on draft CKS topics. Individuals and organizations can also register an interest to feedback on a specific topic, or topics in a particular clinical area, through the Getting involved section of the Clarity Informatics website.
- Stakeholders identified from the following groups are invited to review draft topics:
- Experts in the topic area.
- Professional organizations and societies (for example, Royal Colleges).
- Patient organizations, Clarity has established close links with groups such as Age UK and the Alzheimer’s Society specifically for their input into new topic development, review of current topic content and advice on relevant areas of expert knowledge.
- Guideline development groups where the topic is an implementation of a guideline.
- The British National Formulary team.
- The editorial team that develop MeReC Publications.
- Reviewers are provided with clear instructions about what to review, what comments are particularly helpful, how to submit comments, and declaring interests.
Patient engagement
Clarity Informatics has enlisted the support and involvement of patients and lay persons at all stages in the process of creating the content which include:
- Topic selection
- Scoping of topic
- Selection of clinical scenarios
- First draft internal review
- Second draft internal review
- External review
- Final draft and pre-publication
Our lay and patient involvement includes membership on the editorial steering group, contacting expert patient groups, organizations and individuals.
Evidence exclusion criteria
Our policy
Scoping a literature search, and reviewing the evidence for CKS is a methodical and systematic process that is carried out by the lead clinical author for each topic. Relevant evidence is gathered in order that the clinical author can make fully informed decisions and recommendations. It is important to note that some evidence may be excluded for a variety of reasons. These reasons may be applied across all CKS topics or may be specific to a given topic.
Studies identified during literature searches are reviewed to identify the most appropriate information to author a CKS topic, ensuring any recommendations are based on the best evidence. We use the principles of the GRADE and PICOT approaches to assess the quality of published research. We use the principles of AGREE II to assess the quality of published guidelines.
Standard exclusions for scoping literature:
- Animal studies
- Original research is not written in English
Possible exclusions for reviewed literature:
- Sample size too small or study underpowered
- Bias evident or promotional literature
- Population not relevant
- Intervention/treatment not relevant
- Outcomes not relevant
- Outcomes have no clear evidence of clinical effectiveness
- Setting not relevant
- Not relevant to UK
- Incorrect study type
- Review article
- Duplicate reference
Organizational, behavioural and financial barriers
Our policy
The CKS literature searches take into consideration the following concepts, which are discussed at the initial scoping of the topic.
- Feasibility
- Studies are selected depending on whether the intervention under investigation is available in the NHS and can be practically and safely undertaken in primary care.
- Organizational and Financial Impact Analysis
- Studies are selected and evaluated on whether the intervention under investigations may have an impact on local clinical service provision or national impact on cost for the NHS. The principles of clinical budget impact analysis are adhered to, evaluated and recorded by the author. The following factors are considered when making this assessment and analysis.
- Eligible population
- Current interventions
- Likely uptake of new intervention or recommendation
- Cost of the current or new intervention mix
- Impact on other costs
- Condition-related costs
- In-direct costs and service impacts
- Time dependencies
- Cost-effectiveness or cost-benefit analysis studies are identified where available.
We also evaluate and include evidence from NICE accredited sources which provide economic evaluations of recommendations, such as NICE guidelines. When a recommended action may not be possible because of resource constraints, this is explicitly indicated to healthcare professionals by the wording of the CKS recommendation.
Declarations of interest
Our policy
Clarity Informatics requests that all those involved in the writing and reviewing of topics, and those involved in the external review process to declare any competing interests. Signed copies are securely held by Clarity Informatics and are available on request with the permission of the individual. A copy of the declaration of interest form which participants are asked to complete annually is also available on request. A brief outline of the declarations of interest policy is described here and full details of the policy is available on the Clarity Informatics website. Declarations of interests of the authors are not routinely published, however competing interests of all those involved in the topic update or development are listed below. Competing interests include:
- Personal financial interests
- Personal family interest
- Personal non-financial interest
- Non-personal financial gain or benefit
Although particular attention is given to interests that could result in financial gains or losses for the individual, competing interests may also arise from academic competition or for political, personal, religious, and reputational reasons. An individual is not obliged to seek out knowledge of work done for, or on behalf of, the healthcare industry within the departments for which they are responsible if they would not normally expect to be informed.
Who should declare competing interests?
Any individual (or organization) involved in developing, reviewing, or commenting on clinical content, particularly the recommendations should declare competing interests. This includes the authoring team members, expert advisers, external reviewers of draft topics, individuals providing feedback on published topics, and Editorial Steering Group members. Declarations of interest are completed annually for authoring team and editorial steering group members, and are completed at the start of the topic update and development process for external stakeholders.
Competing interests declared for this topic:
None.
References
- BNF (2025) British National Formulary. National Institute for Health and Care Excellence. https://bnf.nice.org.uk
- CoSRH (2015) FSRH clinical guideline: Problematic bleeding with hormonal contraception. College of Sexual and Reproductive Healthcare. https://www.cosrh.org [Free Full-text]
- CoSRH (2021) FSRH Statement: Pain associated with insertion of intrauterine contraception. College of Sexual and Reproductive Healthcare. https://www.cosrh.org [Free Full-text]
- CoSRH (2023) FSRH guideline: Emergency contraception (March 2017, amended July 2023). College of Sexual and Reproductive Healthcare. https://www.cosrh.org [Free Full-text]
- CoSRH (2025) FSRH Guideline: Intrauterine contraception (March 2023, amended January 2025). College of Sexual and Reproductive Healthcare. https://www.cosrh.org [Free Full-text]
- Costescu, D., Chawla, R., Hughes, R., et al. (2022) Discontinuation rates of intrauterine contraception due to unfavourable bleeding: a systematic review. BMC women's health 22(1), 82. [Abstract]
- EMC (2025) SPC for Mirena 20 micrograms/24 hours intrauterine delivery system. Electronic Medicines Compendium. Datapharm Communications Ltd. https://www.medicines.org.uk/emc
- MHRA (2015) Intrauterine contraception: uterine perforation - updated information on risk factors. Drug Safety Update 8(11), 3. [Abstract]
- NICE (2016) Contraception. QS129. National Institute of Health and Care Excellence. http://www.nice.org.uk [Free Full-text]
- NICE (2019) Long-acting reversible contraception. National Institute for Health and Care Excellence. http://www.nice.org.uk [Free Full-text]