Chronic rhinosinusitis with nasal polyps is among our most challenging diagnoses to treat, because these patients essentially have chronic, lifelong inflammation that needs chronic, lifelong treatment, says Benjamin Bleier, a sinus surgeon at the Massachusetts Eye and Ear Hospital and an assistant professor of otolaryngology at Harvard Medical School.

Some of the inflammation in chronic rhinosinusitis with nasal polyps seems to arise when the nasal lining overexpresses P-glycoprotein (a protein pump), leading to over-secretion of inflammatory cytokines. Verapamil blocks P-glycoprotein and, in some patients with chronic rhinosinusitis and nasal polyps, dramatically improves symptom scores, according to a new study.

While the study involving 18 patients is too small to confirm efficacy, the improvement in several outcome measures suggest that verapamil should be assessed further at a higher dose. “We observed no significant side-effects at the doses we used, and we were very encouraged by the results of this first step,” says Dr Bleier.

(J Allergy Clin Immunol DOI: 10.1016/j.jaci.2016.11.014)


New antibiotic launched

Pfizer has launched Zavicefta (ceftazidime-avibactam) for adults hospitalised with serious infections

NSAIDs and paracetamol linked to hearing loss

NSAIDs and paracetamol might increase the risk of hearing loss, according to an analysis of 55,850 women


PHE updates guidance on managing common infections

PHE has updated its advice on ’Managing common infections: guidance for primary care’

NHS negligence bill quadruples in a decade

The Government must take steps to rein in the increasing cost of clinical negligence claims as numbers rocket, NAO warns

PDA and NPA demand patient safety pledge

The PDA and NPA have appealed to the Department of Health’s Rebalancing Board to adopt a patient safety ’pledge’